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公开(公告)号：US20240245702A1
公开(公告)日：2024-07-25
申请号：US18491200
申请日：2023-10-20
发明人： Albert Edge , Niliksha Gunewardene
IPC分类号： A61K31/55 , A61K31/137 , A61K31/506 , A61K45/06
CPC分类号： A61K31/55 , A61K31/137 , A61K31/506 , A61K45/06
摘要： Methods for the generation of sensorineural hair cells, and more particularly to the use of epigenetic modulation of Atoh1 expression using a combination of Histone Lysine Demethylase (KDM) inhibitors and Wnt activators to generate sensorineural hair cells.
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公开(公告)号：US12043653B2
公开(公告)日：2024-07-23
申请号：US17750530
申请日：2022-05-23
发明人： Zheng-Yi Chen , David R. Liu , Margie Li , David B. Thompson , John Zuris
IPC分类号： C07K14/705 , A61K9/00 , A61K9/50 , A61K38/00 , A61P27/16 , C07K14/435 , C07K14/46 , C07K14/47 , C12N5/071 , C12N5/0793
CPC分类号： C07K14/705 , A61K9/0046 , A61K9/5068 , A61P27/16 , C07K14/43595 , C07K14/463 , C07K14/47 , C12N5/062 , C12N5/0627 , A61K38/00 , C07K2319/00 , C12N2501/42 , C12N2501/60 , C12N2501/606 , C12N2501/998 , C12N2506/00
摘要： Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.
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公开(公告)号：US20240108214A1
公开(公告)日：2024-04-04
申请号：US18490502
申请日：2023-10-19
发明人： Eric Gaier , Dean Travers , Scott Xiao
CPC分类号： A61B3/028 , A61B3/0058 , G02B27/005
摘要： A system and methods for the treatment of amblyopia are described. The system includes a display system capable of delivering a second image to a second eye of a patient and a first image to a first eye of a patient. The system also includes a controller capable of delaying the delivery of the second image to the second eye of the patent. The controller is configured to receive the second image and the first image. The controller is also configured to identify a delay factor associated with the second image. The controller is also configured to provide the first image to the display system for viewing by the first eye of the patient. The controller is also configured such that after a delay determined by the delay factor, the controller provides the second image to the display system for viewing by the second eye of the patient.
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公开(公告)号：US20240050621A1
公开(公告)日：2024-02-15
申请号：US17766445
申请日：2020-10-08
发明人： Reza Dana , Nasim Annabi , Clotilde Jumelle , Ehsan Shirzaei Sani
CPC分类号： A61L24/08 , A61L24/0031 , A61L24/043 , A61L2430/16
摘要： The present disclosure presents sealant compositions which can be used in the treatment of an ocular surface injury and methods of treating an ocular surface injury in a subject in need thereof. The sealant compositions can include methacrylated hyaluronic acid (MeHA); GelMA; optionally, poly(ethylene glycol) diacrylate (PEGDA); and a visible light-activated photoinitiator. The methods include applying a sealant composition to an applicator; placing the applicator containing the sealant composition onto a surface of the eye of a subject, wherein the surface of the eye has or is suspected of having the ocular surface injury; and photo-crosslinking the sealant composition by exposing the applicator and the sealant composition to a visible light, for example, a visible light having a wavelength of about 400 nanometers (nm) to 800 nm.
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公开(公告)号：US20240016956A1
公开(公告)日：2024-01-18
申请号：US18036135
申请日：2021-11-09
申请人： AFFINIA THERAPEUTICS INC. , MASSACHUSETTS EYE AND EAR INFIRMARY , THE SCHEPENS EYE RESEARCH INSTITUTE, INC.
CPC分类号： A61K48/0083 , C12N15/86 , A61K39/42 , C07K16/081 , A61P39/00 , C12N2750/14143 , C12N2750/14171 , A61K2039/505
摘要： The present disclosure relates to an improved method of treating a patient with a recombinant adeno-associated virus (rAAV) by adjunctively administering to the patient via systemic administration a composition comprising at least one antibody or antigen-binding fragments thereof that is capable of neutralizing the non-systemically administered rAAV. The present disclosure further provides kits for the combination therapy.
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6.发明公开公开(公告)号：US20230414838A1
公开(公告)日：2023-12-28
申请号：US18152100
申请日：2023-01-09
CPC分类号： A61L27/52 , A61L27/26 , A61L27/58 , A61L2430/16 , A61L2400/06
摘要： The invention provides methods and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.
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公开(公告)号：US11786117B2
公开(公告)日：2023-10-17
申请号：US17084412
申请日：2020-10-29
IPC分类号： A61B3/08 , A61B3/15 , A61B3/00 , A61B3/10 , A61B3/14 , G06V10/141 , G06V10/10 , G06V10/147 , G06V40/19 , G06V40/18 , G06V40/60
CPC分类号： A61B3/085 , A61B3/00 , A61B3/08 , A61B3/10 , A61B3/14 , A61B3/152 , G06V10/141 , G06V10/147 , G06V10/17 , G06V40/19 , G06V40/193 , G06V40/67
摘要： Disclosed are a mobile device and method which include acquiring, by an image acquisition unit installed in a mobile device, an image of eyes of a patient while light provided by a light source reflects from an optical surface of the eyes of the patient; and obtaining, by a processor installed in the mobile device, ocular misalignment measurements, including a magnitude and a direction of ocular misalignment in the eyes of the patient, using the acquired image or set of images.
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公开(公告)号：US20230287359A1
公开(公告)日：2023-09-14
申请号：US18308590
申请日：2023-04-27
发明人： Luk H. Vandenberghe , Eric Zinn
CPC分类号： C12N7/00 , C07K14/00 , C12N15/86 , A61K39/00 , C07K14/005 , C07K16/22 , C12N2750/14121 , C12N2750/14122 , C12N2750/14141 , C12N2750/14143 , C12N2750/14171 , A61K2039/525 , A61K2039/6075 , C12N2750/14142 , C07K2317/24 , C07K2317/76 , C12N2750/14123
摘要： Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
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公开(公告)号：US11739326B2
公开(公告)日：2023-08-29
申请号：US16763880
申请日：2018-11-14
IPC分类号： C12N15/113 , A61P27/02 , A61K9/00 , A61K31/4025 , A61K31/5513 , A61K31/7105 , A61K45/06 , G01N33/68
CPC分类号： C12N15/113 , A61K9/0048 , A61K31/4025 , A61K31/5513 , A61K31/7105 , A61K45/06 , A61P27/02 , G01N33/6893 , C12N2310/14 , G01N2333/4706 , G01N2800/164
摘要： The present subject matter provides compositions, formulations and methods for preventing or reducing proliferation or migration of retinal cells or epithelial to mesenchymal transition in ocular cells or cells from other tissues.
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10.发明公开公开(公告)号：US20230225823A1
公开(公告)日：2023-07-20
申请号：US17996715
申请日：2021-04-20
发明人： Alicia M. Quesnel , Aaron Remenschneider , Elliot D. Kozin , Daniel J. Lee , Jenny X. Chen , Divya A. Chari
CPC分类号： A61B90/40 , A61B90/05 , A61B2090/401
摘要： A system can include a barrier configured to form a three-dimensional (3D) structure to define an interior volume and an exterior space and to mitigate fluid movement from the interior volume and into the exterior space thereby mitigating droplet, articulate, and aerosol movement in the flow path of the fluid from the interior volume and into the exterior space. The system can include a plurality of passages extending through the barrier to provide access from the exterior space and into the interior volume to perform the procedure on the patient or perform the study on the laboratory sample arranged in the interior volume. The barrier can be configured to be formed in the 3D structure to arrange a portion of the patient or the laboratory sample in the interior volume. The barrier can be external to the patient.
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