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公开(公告)号：US20230232833A1
公开(公告)日：2023-07-27
申请号：US18012095
申请日：2021-06-29
申请人： Universite d'Angers
摘要： The present invention relates to binary and ternary synergistic combinations and to mosquito insecticides and mosquito larvicides containing such synergistic combinations. The present invention also concerns the use of the mosquito insecticides and mosquito larvicides in the control of mosquito-borne diseases, such as, for example, malaria, dengue, Zika, chikungunya and yellow fever.
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公开(公告)号：US20220054424A1
公开(公告)日：2022-02-24
申请号：US17274918
申请日：2019-09-16
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - , UNIVERSITE D'ANGERS , CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS
IPC分类号： A61K9/51 , A61K31/282 , A61P35/00
摘要： The treatment of cancer using platinum-based compounds includes certain drawbacks such as biocompatibility, loading efficacy, leakage of drugs during storage and in the bloodstream, more particularly due to the nature of the nanocarriers for platinum delivery. A nanosystem that allows improving platinum-based drug in vivo performance, kinetics and efficacy. In particular, nanoparticles useful as drug delivery system, these nanoparticles being formed from at least: (a) platinum-based drug, (b) poly-L-arginine, and (c) hyaluronic acid. Particularly, these nanoparticles have been tested in terms of entrapment efficiency and also carried out in vitro experiments in 2D cell culture (viability studies on B6KPC3, A549 and HT-29 cells) and 3D cell model (spheroids made of HTC-116) and in vivo experiments (by injecting intravenously to mice the nanoparticles or comparative oxaliplatin solution) to prove their efficiency.
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公开(公告)号：US20200239404A1
公开(公告)日：2020-07-30
申请号：US16844077
申请日：2020-04-09
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE NANTES , UNIVERSITE D'ANGERS , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALT
IPC分类号： C07C201/12 , C07C253/30 , C07D207/46 , C07C247/16 , C07C247/10 , C07B59/00 , C07C41/18 , C07C67/307 , C07C33/46 , C07C29/58 , C07C29/10 , C07C29/62 , C07C43/225 , C07C17/361 , C07C25/24
摘要： The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.
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公开(公告)号：US10703708B2
公开(公告)日：2020-07-07
申请号：US15777828
申请日：2016-11-24
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE NANTES , UNIVERSITE D'ANGERS , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： C07C201/12 , C07C67/307 , C07C41/18 , C07B59/00 , C07C247/10 , C07C247/16 , C07D207/46 , C07C253/30 , C07C25/24 , C07C17/361 , C07C43/225 , C07C29/62 , C07C29/10 , C07C29/58 , C07C33/46
摘要： The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.
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公开(公告)号：US10269118B2
公开(公告)日：2019-04-23
申请号：US15808136
申请日：2017-11-09
摘要： A method for assessing the presence and/or the severity of a lesion in an organ or tissue of a subject through automated analysis of at least one image of the organ or tissue is provided. In particular, the organ or tissue is a liver organ or liver tissue. The method includes the calculation of a score that combines descriptors of the image, and includes the steps of: a) measuring on the image at least two descriptors of the image, b) mathematically combining the descriptors in a score; and c) assessing the presence and/or the severity of a lesion in the organ or tissue based on the value of the score calculated at step b).
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公开(公告)号：US10202433B2
公开(公告)日：2019-02-12
申请号：US14897344
申请日：2014-06-27
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Universite de Nantes , Centre National de la Recherche Scientifique (CNRS) , Universite D'Angers
发明人： Yannick Jacques , Erwan Mortier , Agnes Quemener , Ariane Plet
摘要： The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In particular, the present invention relates to an IL-15 mutant polypeptide having the amino acid sequence as set forth in SEQ ID NO:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagines residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue.
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公开(公告)号：US20180271101A1
公开(公告)日：2018-09-27
申请号：US15780881
申请日：2016-12-02
申请人： UNIVERSITE D'ANGERS
摘要： Insecticide composition wherein the active ingredient comprises the combination of a neonicotinoid insecticide, thiamethoxam as synthetic insecticide molecule, and at least one synergistic agent, which is chosen among the insect repellent agents such as DEET and/or IR3535® and present at a molar ratio of said synergistic agent to thiamethoxam comprised between O.OOI and 0.2 in the composition. Synergistic effect is observed at low doses. Use of the insecticide composition wherein said composition is sprayed or deposited on, or impregnated to a support, such as net, fabrics, cloth or tent, in the fight against insects which are harmful to human, to animals and/or to crops, and in particular against pyrethroid, carbanate and/or organophosphate resistant mosquitoes.
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公开(公告)号：US20180258174A1
公开(公告)日：2018-09-13
申请号：US15754664
申请日：2016-09-15
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERISTE DE NANTES , UNIVERSITE D'ANGERS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
IPC分类号： C07K16/28 , A61K39/395 , C07K14/54 , C07K14/715 , C07K19/00
CPC分类号： C07K16/2866 , A61K38/1774 , A61K38/1793 , A61K38/2086 , A61K39/39533 , A61P37/06 , C07K14/5443 , C07K14/7155 , C07K19/00 , C07K2317/52 , C07K2317/76 , C07K2319/01 , C12N15/62 , Y02A50/401 , Y02A50/414
摘要： The present invention relates to specific interleukin-15 (IL-15) antagonist polypeptides and uses thereof for the treatment of inflammatory and auto-immune diseases. In particular, the present invention relates to a specific interleukin-15 (IL-15) antagonist polypeptide comprising i) a IL15-Ralpha sushi-containing polypeptide comprising an amino acid sequence having at least 80% of identity with the amino acid sequence of SEQ ID NO:1 ii) a linker and iii) an IL-polypeptide comprising the amino acid sequence having at least at least 80% of identity with the amino acid sequence of SEQ ID NO:4 provided that the glutamine (Q) residue at position 108 is mutated.
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公开(公告)号：US09987327B2
公开(公告)日：2018-06-05
申请号：US15295281
申请日：2016-10-17
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE EA RECHERCHE MEDICALE) , UNIVERSITE DE MONTPELLIER , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS , UNIVERSITE PARIS EST CRETEIL VAL DE MARNE , UNIVERSITE D'ANGERS
发明人： Alain Lacampagne , Jerome Thireau , Olivier Cazorla , Jean-Yves Le Guennec , Jeremy Fauconnier , Maria del Carmen Martinez , Ramaroson Andriantsitohaina , Bijan Ghaleh-Marzban , Raffaella Soleti
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/16 , A61P9/06 , A61P9/10 , C07K14/47 , C07K14/4705 , C07K2319/30
摘要： The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in the cardioprotection of a subject who experienced a myocardial infarction.
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公开(公告)号：US09830699B2
公开(公告)日：2017-11-28
申请号：US14771997
申请日：2014-02-28
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/90 , G06T2207/10056 , G06T2207/30056 , G06T2207/30096
摘要： The present invention relates to a method for assessing the presence and/or the severity of a lesion in an organ or tissue of a subject through automated analysis of at least one image of said organ or tissue, wherein said organ or tissue is preferably a liver organ or liver tissue, comprising the calculation of a score combining descriptors of said image, wherein said method comprises the steps of: a. measuring on said at least one image at least two descriptors of said at least one image; b. mathematically combining said at least two descriptors in a score; and c. assessing the presence and/or the severity of a lesion in the organ or tissue based on the value of the score calculated at step (b).
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