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    MALDI SAMPLE PREPARATION METHODS AND TARGETS
    1.
    发明申请
    MALDI SAMPLE PREPARATION METHODS AND TARGETS 审中-公开
    MALDI样品制备方法和目标

    公开(公告)号：US20150162176A1

    公开(公告)日：2015-06-11

    申请号：US14234772

    申请日：2012-07-25

    申请人： Ursula Gäb

    发明人： Oliver J. Schmitz ,  Volker Wulf ,  Lukas Hyzak ,  Michaela Wirtz ,  David Melchior ,  Hans Willi Kling ,  Siegmar Gäb

    IPC分类号： H01J49/00 ,  H01J49/16 ,  G01N1/38

    CPC分类号： H01J49/0031 ,  G01N1/38 ,  H01J49/0036 ,  H01J49/0418 ,  H01J49/0459 ,  H01J49/164

    摘要： The present invention is concerned with a method of preparing a MALDI sample, the method comprising the steps of: (a) mixing a solid sample precursor comprising sample and matrix to form a solid sample mixture; (b) applying the solid sample mixture to a sample cavity of a MALDI target; and (c) compressing the solid sample mixture in the sample cavity so as to form a MALDI sample surface for laser desorption. The present invention also provides a MALDI target comprising a sample cavity for receiving a MALDI sample, the sample cavity having (a) a desorption end portion comprising an aperture, such that a portion of the MALDI sample exposed at the aperture is in use subjected to laser desorption; and wherein the sample cavity also has (b) a compression end portion adapted to permit compression of a solid sample mixture towards the desorption end portion in the sample cavity by applying a compression force to the solid sample mixture via the compression end portion.

    摘要翻译： 本发明涉及一种制备MALDI样品的方法，该方法包括以下步骤：（a）将包含样品和基质的固体样品前体混合以形成固体样品混合物; （b）将固体样品混合物施加到MALDI靶的样品腔中; 和（c）压缩样品腔中的固体样品混合物，以便形成用于激光解吸的MALDI样品表面。 本发明还提供了一种MALDI靶，其包括用于接收MALDI样品的样品腔，所述样品腔具有（a）包含孔的解吸端部，使得在所述孔处露出的部分MALDI样品在使用中受到 激光解吸; 并且其中所述样品腔还具有（b）压缩端部，其适于通过经由所述压缩端部向所述​​固体样品混合物施加压缩力而使固体样品混合物朝向所述样品腔中的解吸端部压缩。