公开(公告)号：US20240005439A1

公开(公告)日：2024-01-04

申请号：US18255557

申请日：2021-12-02

Applicant: VESTLANDETS INNOVASJONSSELSKAP AS (VIS)

Inventor： Olav TENSTAD ,  Tom Christian Holm ADAMSEN

IPC: G06T1/00 ,  G06T7/00 ,  A61K51/08

CPC classification number: G06T1/0007 ,  G06T7/00 ,  A61K51/088 ,  G06T2207/10104 ,  G06T2207/30084

Abstract: A method of imaging a subject, the method comprising the steps: administering a radiotracer to the subject such that the radiotracer enters the bloodstream of the subject; allowing the radiotracer to accumulate in a kidney of the subject; and imaging said kidney using positron emission tomography (PET); wherein the radiotracer comprises a protein labelled with a 6-[18F]fluoropyridin-3-ylcarboxy group. The disclosure also relates to radiotracers and compositions suitable for use in said method, as well as to processes, kits and cassettes for preparing said radiotracers.

公开(公告)号：US20210057190A1

公开(公告)日：2021-02-25

申请号：US17052346

申请日：2019-05-08

Applicant: Vestlandets Innovasjonsselskap AS

Inventor： Justas ZALIECKAS

IPC: H01J37/32 ,  C23C16/511

Abstract: A large area microwave plasma chemical vapour deposition, LA MPCVD reactor apparatus and method for large area microwave chemical vapour deposition, comprising a reactor chamber adapted to provide a plasma region in an interior of the reactor chamber by electromagnetic energy at a first frequency, and a CRLH waveguide section adapted to operate with an infinite wavelength at the first frequency and having in a wall a coupler means arranged to couple electromagnetic energy from an interior of the CRLH waveguide section to the interior of the reactor chamber.

公开(公告)号：US20230138584A1

公开(公告)日：2023-05-04

申请号：US18064850

申请日：2022-12-12

Applicant: Vestlandets Innovasjonsselskap AS (VIS)

Inventor： Vegard TUSETH

IPC: A61B6/10 ,  G21F1/08

Abstract: The present disclosure relates to a radiation shield device comprising a sheet of material comprising a plurality of flaps, wherein the sheet comprises a barrier to ionizing radiation. The present disclosure also relates to a method for manufacturing said radiation shield device.

公开(公告)号：US11364122B2

公开(公告)日：2022-06-21

申请号：US16492504

申请日：2018-03-12

Applicant: VESTLANDETS INNOVASJONSSELSKAP AS

Inventor： Kamal Babikeir Eln Mustafa ,  Ahmad Rashad Saad Mohamed Elsebahy ,  Anna Finne Wistrand ,  Yang Sun ,  Alexander Franciscus Van Tol

IPC: A61F2/30 ,  A61F2/28

Abstract: A scaffold (12) for tissue engineering comprises an inner portion (14), an outer portion (16), and a base portion (22) connecting the inner portion and the outer portion. The inner portion (14) comprises a channel (18) surrounded by a first set of one or more walls. The outer portion (16) comprises a second set of one or more walls. The portions are arranged such that the second set of one or more walls substantially surrounds the first set of one or more walls with a spacing between the first and second sets of walls defining a cavity (20) between the inner portion (14) and the outer portion (16). The inner portion (14) and the outer portion (16) may have different shapes; and/or the scaffold (12) may further comprise a filler material in the cavity (20) defined between the inner and outer portions.

公开(公告)号：US20250011874A1

公开(公告)日：2025-01-09

申请号：US18521691

申请日：2023-11-28

Applicant: Vestlandets Innovasjonsselskap AS

Inventor： Lars A. Akslen ,  Silje Kjølle ,  Kenneth Finne ,  Dimitrios Kleftogiannis

IPC: C12Q1/6886 ,  G01N33/574

Abstract: The present invention relates to methods of obtaining indications of the prognosis of breast cancer subjects, for classifying breast tumours and for predicting the therapeutic effectiveness of radiotherapy treatment on a subject with breast cancer. The methods are based on the production of a signature score which is derived from expression levels of a plurality of specific protein or RNA biomarkers.

公开(公告)号：US20240216370A1

公开(公告)日：2024-07-04

申请号：US17800648

申请日：2021-02-18

Applicant: VESTLANDETS INNOVASJONSSELSKAP AS

Inventor： Cecilie BREDRUP ,  Ove BRULAND ,  Eyvind RØDAHL ,  Gunnar HOUGE

IPC: A61K31/506 ,  A61K9/00 ,  A61K9/14 ,  C12Q1/6883

CPC classification number: A61K31/506 ,  A61K9/0048 ,  A61K9/14 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to methods for treating or preventing vascularisation in one or both corneas of a subject. The methods comprise topically administering an effective amount of a composition comprising dasatinib to one or both eyes of the subject. The method is particularly useful for treating subjects with corneal vascularisation associated with ocular pterygium-digital keloid dysplasia (OPDKD), Warburg-Cinotti syndrome (WCS) or Penttinen syndrome, and other conditions caused by activating mutations in PDGFRβ and DDR2.

公开(公告)号：US20230390278A1

公开(公告)日：2023-12-07

申请号：US18031765

申请日：2021-10-12

Applicant: VESTLANDETS INNOVASJONSSELSKAP AS

Inventor： Bjørn Tore GJERTSEN ,  Vibeke ANDRESEN ,  Calum LEITSCH

IPC: A61K31/473 ,  A61K31/19 ,  A61P35/02 ,  A61K9/20

CPC classification number: A61K31/473 ,  A61K31/19 ,  A61P35/02 ,  A61K9/20

Abstract: The present invention relates to synergistic combinations of quinacrine and valproic acid for the treatment of cancer, preferably acute myeloid leukaemia (AML); and methods of treating cancer using such synergistic combinations.

公开(公告)号：US20230346555A1

公开(公告)日：2023-11-02

申请号：US17997817

申请日：2022-01-20

Applicant: Vestlandets Innovasjonsselskap AS (VIS)

Inventor： Vegard TUSETH

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2466 ,  A61F2220/0016 ,  A61F2230/0095

Abstract: An annuloplasty device for restoring a heart valve annulus from a dysfunctional configuration to a working configuration, wherein the device comprises a band which is expandable from a pre-set configuration, wherein the pre-set configuration of the band corresponds to the working configuration of the annulus.

公开(公告)号：US20230286919A1

公开(公告)日：2023-09-14

申请号：US17995143

申请日：2021-04-01

Applicant: Vestlandets Innovasjonsselskap AS ,  Shanghai University of Traditional Chinese Medicine

Inventor： Yaping Hua ,  Karl-Henning Kalland ,  Weidong Zhang ,  Xisong Ke ,  Yunheng Shen ,  Anne Margrete Øyan

IPC: C07D221/16 ,  A61P29/00 ,  A61K45/06 ,  A61P13/08

CPC classification number: C07D221/16 ,  A61P29/00 ,  A61K45/06 ,  A61P13/08

Abstract: The present invention provides a compound of Formula (I), or a solvate, a tautomer, a stereoisomer or a salt thereof, for use in the treatment of cancer, in particular prostate cancer. These compounds are of use in cancer immunotherapy and may be used in combination therapies with immune checkpoint inhibitors and tumour microenvironment modulators. The invention also provides compositions comprising the compounds of the invention, as well as the use of compounds of the invention as STAT3 inhibitors.

公开(公告)号：US20220339174A1

公开(公告)日：2022-10-27

申请号：US17638453

申请日：2020-08-31

Applicant: Vestlandets Innovasjonsselskap AS

Inventor： Øystein FLUGE ,  Olav MELLA

IPC: A61K31/69 ,  A61P25/00 ,  A61K38/07 ,  A61K38/06 ,  A61K31/407 ,  A61K39/395

Abstract: The present invention relates in a first aspect to a method for the treatment of chronic fatigue syndrome (CFS) comprising administering to a patient in need thereof a therapeutically effective amount of inhibitory or cytotoxic agent against plasma cells. In a further aspect, the present invention relates to a combination of the inhibitory or cytotoxic agent against plasma cells with a B-cell depleting agent or an inhibitor of B-cell activation in the treatment of chron-ic fatigue syndrome. In addition, a combination of an inhibitory or cytotoxic agent against plasma cells and B-Cell depleting agent or an inhibitor of B-cell activation are described. Said combination may be provided in form of a kit comprising suitably effective dosages of said compounds. Further, the use of the compounds or the combination in the treatment of CFS is described.