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公开(公告)号：US08927765B2
公开(公告)日：2015-01-06
申请号：US13289592
申请日：2011-11-04
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
IPC分类号： C07C53/134 , C07C57/30 , C07C61/39 , C07D257/04 , C07C59/48 , C07D213/55 , C07C57/58 , C07C59/52
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译： 本发明涉及取代的式I的芳族化合物及其药物用途。 本发明的特定方面涉及这些化合物在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防或治疗（i）血液病症，（ii）肾病，肾病或肾脏 疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。
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公开(公告)号：US20120088784A1
公开(公告)日：2012-04-12
申请号：US13289592
申请日：2011-11-04
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
IPC分类号： A61K31/192 , C07C57/42 , C07C59/52 , C07C57/50 , C07D213/55 , A61K31/44 , C07D257/04 , A61K31/41 , A61P7/00 , A61P13/12 , A61P29/00 , A61P9/10 , A61P7/06 , A61P37/00 , A61P19/02 , A61P19/04 , A61P17/06 , A61P1/00 , A61P27/02 , A61P9/00 , A61P35/00 , A61P3/10 , A61P25/16 , A61P9/04 , A61P25/28 , A61P25/00 , C07C57/30
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译： 本发明涉及取代的式I的芳族化合物及其药物用途。 本发明的特定方面涉及这些化合物在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防或治疗（i）血液病症，（ii）肾病，肾病或肾脏 疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。
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公开(公告)号：US20120095102A1
公开(公告)日：2012-04-19
申请号：US13318252
申请日：2010-05-03
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
IPC分类号： A61K31/192 , C07C51/09 , A61P7/00 , A61P13/12 , A61P29/00 , A61P7/06 , A61P37/06 , A61P19/02 , A61P9/00 , A61P17/06 , A61P1/00 , A61P27/02 , A61P35/00 , A61P3/10 , A61P9/10 , A61P25/16 , A61P9/04 , A61P25/28 , A61P43/00 , C07C57/30
CPC分类号： A61K31/192 , C07C51/412 , C07C57/30 , C07C67/303 , C07C67/343 , C07C69/612 , C07C69/618
摘要： The present invention relates to salts of 3-pentylphenylacetic acid and their pharmaceutical uses. Particular aspects of the invention relate to the use of those salts in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention and treatment of (i) blood disorders, (ii) renal disorders and renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译： 本发明涉及3-戊基苯乙酸的盐及其药物用途。 本发明的特定方面涉及这些盐在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防和治疗（i）血液病症，（ii）肾脏疾病和肾脏疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。
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公开(公告)号：US07388008B2
公开(公告)日：2008-06-17
申请号：US10902935
申请日：2004-08-02
IPC分类号： C07D215/12 , C07D241/36 , A61K31/44
CPC分类号： C07F9/091 , C07D213/30 , C07D213/38 , C07F9/6533
摘要： The present invention provides lysine based compounds of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1 may be, for example, (HO)2P(O)—, (NaO)2P(O)—, alkyl-CO— or cycloalkyl-CO—, wherein X may be, for example, F, Cl, and Br, and wherein R2 and R3 are as defined herein.
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公开(公告)号：US08637574B2
公开(公告)日：2014-01-28
申请号：US13318252
申请日：2010-05-03
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-Francois Bienvenu , Valérie Perron , Brigitte Grouix
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-Francois Bienvenu , Valérie Perron , Brigitte Grouix
CPC分类号： A61K31/192 , C07C51/412 , C07C57/30 , C07C67/303 , C07C67/343 , C07C69/612 , C07C69/618
摘要： The present invention relates to salts of 3-pentylphenylacetic acid and their pharmaceutical uses. Particular aspects of the invention relate to the use of those salts in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention and treatment of (i) blood disorders, (ii) renal disorders and renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译： 本发明涉及3-戊基苯乙酸的盐及其药物用途。 本发明的特定方面涉及这些盐在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防和治疗（i）血液病症，（ii）肾脏疾病和肾脏疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。
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公开(公告)号：US06632816B1
公开(公告)日：2003-10-14
申请号：US10326488
申请日：2002-12-23
IPC分类号： A61K31455
CPC分类号： C07D213/81 , A61K31/455 , A61K31/5375 , C07C311/40 , C07C2601/02 , C07C2601/08 , C07D207/34 , C07D233/90 , C07D237/24 , C07D295/215 , C07D307/24
摘要： The present invention provides HIV aspartyl protease inhibitors of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, wherein R1 may be, for example, iso-butyl, wherein X and Y, same or different, may be, for example, NH2 and F, and wherein R2 and R3 are as defined herein.
摘要翻译： 本发明提供了具有下式的HIV天冬氨酰蛋白酶抑制剂;当式I化合物包含氨基时，其药学上可接受的铵盐，其中n为3或4，其中R 1 < 可以是例如异丁基，其中X和Y可以相同或不同，例如可以是NH 2，其中R 1， HIL>
2 和R 3 如本文所定义。
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