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公开(公告)号：US20070123515A1
公开(公告)日：2007-05-31
申请号：US11604412
申请日：2006-11-27
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Oliver Roche , Valerie Runtz-Schmitt , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Oliver Roche , Valerie Runtz-Schmitt , Sven Taylor
IPC分类号： A61K31/55 , A61K31/541 , A61K31/454 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1至R 4和G如说明书和权利要求及其药学上可接受的盐所定义。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US5981519A
公开(公告)日：1999-11-09
申请号：US986549
申请日：1997-12-08
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D417/12 , C07D501/00 , C07D501/04 , C07D501/06 , C07D501/24 , C07D501/34 , C07D501/56 , C07F9/572 , C07F9/6558
CPC分类号： C07D417/12 , C07D501/00 , C07F9/5726 , C07F9/65583 , Y02P20/55
摘要： The present invention relates to compounds having the formula ##STR1## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are as defined herein as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts. These compounds have valuable pharmacological activity for the treatment and prophylaxis of infectious diseases, especially those caused by methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa.
摘要翻译： 本发明涉及具有下式的化合物：其中X，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义，以及其易水解的酯，所述化合物的药学上可接受的盐和化合物的水合物 配方Ⅰ及其酯和盐。 这些化合物具有有价值的药理活性，用于治疗和预防感染性疾病，特别是由耐甲氧西林金黄色葡萄球菌（MRSA）和铜绿假单胞菌引起的那些。
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公开(公告)号：US07745479B2
公开(公告)日：2010-06-29
申请号：US11604412
申请日：2006-11-27
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Valerie Runtz-Schmitt , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Valerie Runtz-Schmitt , Sven Taylor
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/454 , A61K31/4545 , A61K31/4045 , C07D209/42 , C07D401/02 , C07D413/02 , C07D417/02
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1至R 4和G如说明书和权利要求及其药学上可接受的盐所定义。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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