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34 条记录 (耗时 0.014 秒)

    Diphosphines containing silane groups, immobilise diphosphines and the use thereof as hydrogenation catalysts
    2.
    发明授权
    Diphosphines containing silane groups, immobilise diphosphines and the use thereof as hydrogenation catalysts 失效
    含有硅烷基团的二羟基磷灰石，硫化二磷酸酯及其作为氢化催化剂的用途

    公开(公告)号：US5244857A

    公开(公告)日：1993-09-14

    申请号：US823517

    申请日：1992-01-21

    申请人： Benoit Pugin ,  Manfred Muller ,  Felix Spindler

    发明人： Benoit Pugin ,  Manfred Muller ,  Felix Spindler

    IPC分类号： B01J31/02 ,  B01J31/16 ,  B01J31/22 ,  B01J31/24 ,  C07C29/145 ,  C07F9/572 ,  C07F15/00

    CPC分类号： C07F15/008 ,  B01J31/1633 ,  B01J31/2291 ,  B01J31/2409 ,  C07F15/004 ,  C07F9/5722 ,  C07F9/5726 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/822 ,  B01J2531/827 ,  Y02P20/588

    摘要： Compounds of formula II ##STR1## wherein the groups (R.sub.1).sub.2 P(CH.sub.2).sub.m and n are in o- or m-position to each other and the substituents R.sub.1 are identical or different radicals, m and n are each independently of the other 0 or 1, R.sub.1 is linear or branched C.sub.1 -C.sub.12 alkyl, unsubstituted C.sub.5 -C.sub.6 cycloalkyl or C.sub.5 -C.sub.6 cycloalkyl which is substituted by C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, or is phenyl or benzyl, or both substituents R.sub.1 in a group (R.sub.1).sub.2 P together are o,o'-diphenylene, --R.sub.2 --X-- is a bond or --(C.sub.x H.sub.2x --O).sub.y --, or X-- is O-- and R.sub.2 is C.sub.1 -C.sub.6 alkylene, x is an integer from 2 to 6 and y is an integer from 2 to 6, R.sub.3 is C.sub.2 -C.sub.18 alkylene, phenylene or benzylene, and R.sub.4 is C.sub.1 -C.sub.6 alkyl or phenyl, can be applied to solid carriers, such as silica gel or aerosils, and complexed with rhodium or iridium compounds. These materials are heterogeneous and separable catalysts for the asymmetrical hydrogenation of prochiral compounds containing carbon double bonds or carbon/hetero atom double bonds, for example ketones and imines.

    摘要翻译： 式（II）化合物其中基团（R 1）2 P（CH 2）m和n彼此相邻或相邻位置，并且取代基R 1是相同或不同的基团，m和n各自独立地为 的另一个0或1，R 1是被C 1 -C 4烷基或C 1 -C 4烷氧基取代的直链或支链C 1 -C 12烷基，未取代的C 5 -C 6环烷基或C 5 -C 6环烷基，或是苯基或苄基，或两个取代基R 1 R1）2P一起是o，o'-二亚苯基，-R 2 -X-是键或 - （C x H 2 O-O）y - ，或X是O-，R 2是C 1 -C 6亚烷基，x是从2到 6，y为2〜6的整数，R3为C2-C18亚烷基，亚苯基或亚苯基，R4为C1-C6烷基或苯基，可用于固体载体如硅胶或气溶胶，并与铑或铱络合 化合物。 这些材料是用于不对称氢化含有双键或碳/杂原子双键的前手性化合物的非均相和可分离的催化剂，例如酮和亚胺。

    Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
    4.
    发明授权
    Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds 失效
    手性膦基吡咯烷化合物及其用于不对称合成光学活性化合物的用途

    公开(公告)号：US4985567A

    公开(公告)日：1991-01-15

    申请号：US319186

    申请日：1989-03-06

    申请人： Kazuo Achiwa ,  Hideo Takeda

    发明人： Kazuo Achiwa ,  Hideo Takeda

    IPC分类号： C07D207/10 ,  C07B61/00 ,  C07C231/18 ,  C07C233/47 ,  C07D317/60 ,  C07F9/572 ,  C07F15/00

    CPC分类号： C07F15/0073 ,  C07C231/18 ,  C07D317/60 ,  C07F9/5726

    摘要： New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R.sup.1 is hydrogen or --COA.sup.1, --COOA.sup.2, --CONHA.sup.3, --SO.sub.2 A.sup.4 or --PO(A.sup.5).sub.2, A.sup.1, A.sup.2, A.sup.3, A.sup.4 and A.sup.5 each represents independently alkyl or aryl, R.sup.2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R.sup.3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R.sup.2 and R.sup.3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

    Pyrrolidone-5,5-diphosphonic acids
    6.
    发明授权
    Pyrrolidone-5,5-diphosphonic acids 失效
    吡咯烷酮-5,5-二膦酸

    公开(公告)号：US4034086A

    公开(公告)日：1977-07-05

    申请号：US659926

    申请日：1976-02-20

    申请人： Walter Ploger ,  Manfred Schmidt-Dunker ,  Christian Gloxhuber

    发明人： Walter Ploger ,  Manfred Schmidt-Dunker ,  Christian Gloxhuber

    IPC分类号： A61K8/49 ,  A61K8/55 ,  A61K31/675 ,  A61Q11/00 ,  C04B11/024 ,  C07F9/38 ,  C07F9/572

    CPC分类号： C07F9/5726 ,  A61K31/675 ,  A61K8/4913 ,  A61K8/55 ,  A61Q11/00 ,  C07F9/3873 ,  A61K2800/51 ,  Y10S424/06

    摘要： Pyrrolidone-5,5-diphosphonic acids having the formula ##STR1## wherein R is a member selected from the group consisting of hydrogen and alkyl having from 1 to 6 carbon atoms; as well as their water-soluble salts. The pyrrolidone-5,5-diphosphonic acids are excellent sequestering agents especially for alkaline earth metal ions. They are stabilizers for percompounds and are useful in the delaying of the setting times for gypsum. In addition, the compounds are useful as cosmetic preparations such as toothpastes and mouthwashes where they prevent formation of tartar and plaque and are useful in therapy in the treatment of diseases related to the abnormal deposition or dissolution of difficultly soluble calcium salts in the animal body.

    摘要翻译： 具有式“IMAGE”的吡咯烷酮-5,5-二膦酸，其中R是选自氢和具有1至6个碳原子的烷基的成员; 以及它们的水溶性盐。 吡咯烷酮-5,5-二膦酸是特别用于碱土金属离子的优异的螯合剂。 它们是化合物的稳定剂，对于延迟石膏凝固时间是有用的。 此外，这些化合物可用作化妆品制剂如牙膏和漱口剂，其中它们防止形成牙垢和斑块，并且可用于治疗与难溶性钙盐在动物体内的异常沉积或溶解有关的疾病的治疗。

    Process for the enantioselective synthesis of 2(R)-benzylsuccinic acid monoamide derivatives
    8.
    发明授权
    Process for the enantioselective synthesis of 2(R)-benzylsuccinic acid monoamide derivatives 失效
    2（R） - 苄基琥珀酸单酰胺衍生物的对映选择性合成方法

    公开(公告)号：US5321139A

    公开(公告)日：1994-06-14

    申请号：US22887

    申请日：1993-02-16

    申请人： Ulrich Lerch ,  Heiner Jendralla ,  Bernhard Seuring ,  Rainer Henning

    发明人： Ulrich Lerch ,  Heiner Jendralla ,  Bernhard Seuring ,  Rainer Henning

    IPC分类号： B01J31/24 ,  C07B61/00 ,  C07C231/02 ,  C07C231/18 ,  C07C233/14 ,  C07C233/22 ,  C07C233/40 ,  C07D211/44 ,  C07D211/58 ,  C07D241/04 ,  C07F9/572 ,  C07F15/00 ,  C07D211/06

    CPC分类号： C07F15/0013 ,  C07C231/18 ,  C07D211/58 ,  C07F15/008 ,  C07F9/5726

    摘要： Two processes are described for the preparation of the optically pure compounds of formula 1: ##STR1## in which R.sup.1 and R.sup.2 are e.g. alkyl, R.sup.3 and R.sup.4 are e.g. hydrogen and R.sup.5 is e.g. hydrogen. Both processes include, as key steps, the enantioselective hydrogenation of a C.dbd.C double bond and the regioselective formation of a dicarboxylic acid monoamide derivative. In one process a phenylitaconic acid derivative is asymmetrically hydrogenated to give an optically active (R)-benzylsuccinic acid which is then converted to a diester, said diester being converted to the monoamide compound of formula 1. In the second process, a phenylitaconic acid derivative is converted to its anhydride, and the anhydride is then converted to a monoamide which is then asymmetrically hydrogenated to give the compound of formula 1.

    摘要翻译： 描述了制备光学纯的式1化合物的两种方法：其中R 1和R 2是例如： 烷基，R 3和R 4是例如。 氢和R 5是例如。 氢。 作为关键步骤，两种方法都包括C = C双键的对映选择性氢化和二羧酸单酰胺衍生物的区域选择性形成。 在一个过程中，苯基衣康酸衍生物被不对称氢化，得到光学活性（R） - 苄基琥珀酸，然后将其转化为二酯，所述二酯转化成式1的单酰胺化合物。在第二种方法中，苯基衣康酸衍生物 转化成其酐，然后将酸酐转化为单酰胺，然后将其不对称氢化，得到式1的化合物。

    Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
    10.
    发明授权
    Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds 失效
    手性膦基吡咯烷化合物及其用于不对称合成光学活性化合物的用途

    公开(公告)号：US4879389A

    公开(公告)日：1989-11-07

    申请号：US66251

    申请日：1987-06-25

    申请人： Kazuo Achiwa

    发明人： Kazuo Achiwa

    IPC分类号： C07C29/145 ,  C07C41/48 ,  C07C51/36 ,  C07F9/572 ,  C07F15/00

    CPC分类号： C07F15/0073 ,  C07C29/145 ,  C07C41/48 ,  C07C51/36 ,  C07F9/5726 ,  C07B2200/07

    摘要： New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom, --COR, --COOR, --CONHR or --SO.sub.2 --R where R is an alkyl or aryl group, R.sup.2 and R.sup.3 each represents independently an aryl group which may have a substituent or substituents, and R.sup.4 and R.sup.5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

    摘要翻译： 新的手性膦基吡咯烷化合物，其通式如下：其中R 1是氢原子，-COR，-COOR，-CONHR或-SO 2 -R，其中R是烷基或芳基 基团，R 2和R 3各自独立地表示可以具有取代基的芳基，R 4和R 5各自独立地表示可以具有取代基的脂族或脂环族烃基，以及这些化合物作为配体的用途 用于不对称合成光学活性化合物的金属络合物催化剂。 新的手性膦基吡咯烷化合物是有用的配体，其在催化不对称还原中具有高光学收率和高反应效率。