公开(公告)号：US20070117795A1

公开(公告)日：2007-05-24

申请号：US11511129

申请日：2006-08-28

申请人： Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Yeleswarapu ,  Manojit Pal ,  Jangalgar Reddy ,  Velagala Venkata Rama Krishna Reddy ,  Sesha Alluri ,  Potlapally Kumar ,  Gaddam Reddy

发明人： Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Yeleswarapu ,  Manojit Pal ,  Jangalgar Reddy ,  Velagala Venkata Rama Krishna Reddy ,  Sesha Alluri ,  Potlapally Kumar ,  Gaddam Reddy

IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/53 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/54 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.