公开(公告)号：US09241964B2

公开(公告)日：2016-01-26

申请号：US13146965

申请日：2010-02-01

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Krishanu Sengupta ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Krishanu Sengupta ,  Venkata Krishna Raju Alluri

IPC分类号： A61K36/00 ,  A61K36/28 ,  A23L1/30 ,  A61K36/38

CPC分类号： A61K36/38 ,  A23L33/105 ,  A23V2002/00 ,  A61K35/12 ,  A61K36/28 ,  A61K2300/00 ,  A23V2250/21

摘要： The invention relates pharmaceutical/dietary supplement/food ingredient(s) selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Sphaeranthus indicus and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.

摘要翻译： 本发明涉及选自提取物，级分，活性化合物和植物化学物质的衍生自Sphaeranthus indicus及其组合物的药物/膳食补充剂/食物成分，优选组合 与至少一种选自提取物，级分，活性化合物和植物化学物质的组分或其混合物衍生自芒of藤（Garcinia mangostana）。 成分和组成可用于控制，预防和治疗肥胖症，代谢综合征，糖尿病和其他代谢紊乱，并且还调节能量消耗，预防冠状动脉和腹主动脉中的动脉粥样硬化斑块，增加胰岛素 敏感性，改善葡萄糖耐量，降低甘油三酯水平和平衡哺乳动物中的葡萄糖水平。

公开(公告)号：US20100178288A1

公开(公告)日：2010-07-15

申请号：US12602573

申请日：2007-06-01

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Venakteswara Rao Chirravuri ,  Venkata Krishna Raju Alluri ,  Kiran Bhupathiraju

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Venakteswara Rao Chirravuri ,  Venkata Krishna Raju Alluri ,  Kiran Bhupathiraju

IPC分类号： A61K36/58 ,  A61K36/906 ,  A61K36/8962 ,  A61K38/48 ,  A61P37/00 ,  A61P37/08 ,  A61P17/06 ,  A61P11/06

CPC分类号： A61K36/58 ,  A61K2300/00

摘要： The invention discloses 5-lipoxygenase inhibitory product prepared from botanical sources. More specifically, the invention describes 5-lipoxygenase inhibitory extracts or bio-enriched extracts or fractions of Aphanamixis polystachya, methods of making 5-lipoxygenase inhibitory extract, and methods of treating and/or preventing disease conditions mediated by 5-lipoxygenase by using the said extract. The invention further discloses pharmaceutical or nutraceitical or dietary compositions containing therapeutically effective amounts of the extracts of Aphanamixis polystachya in combination with other known anti-inflammatory agents useful for oral, parenteral and topical administration.

摘要翻译： 本发明公开了从植物来源制备的5-脂氧合酶抑制产物。 更具体地，本发明描述了5-脂氧合酶抑制性提取物或生物富集的提取物或聚山梨酸酯的部分，制备5-脂氧合酶抑制性提取物的方法，以及通过使用所述的方法治疗和/或预防5-脂氧合酶介导的疾病状态的方法 提取。 本发明进一步公开了药物或营养学或膳食组合物，其含有治疗有效量的阿泊他尼斯多螨的提取物与用于口服，胃肠外和局部给药的其它已知抗炎药的组合。

公开(公告)号：US08337916B2

公开(公告)日：2012-12-25

申请号：US12602573

申请日：2007-06-01

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Venakteswara Rao Chirravuri ,  Venkata Krishna Raju Alluri ,  Kiran Bhupathiraju

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Venakteswara Rao Chirravuri ,  Venkata Krishna Raju Alluri ,  Kiran Bhupathiraju

IPC分类号： A61K36/00

CPC分类号： A61K36/58 ,  A61K2300/00

摘要： The invention discloses 5-lipoxygenase inhibitory product prepared from botanical sources. More specifically, the invention describes 5-lipoxygenase inhibitory extracts or bio-enriched extracts or fractions of Aphanamixis polystachya, methods of making 5-lipoxygenase inhibitory extract, and methods of treating and/or preventing disease conditions mediated by 5-lipoxygenase by using the said extract. The invention further discloses pharmaceutical or nutraceitical or dietary compositions containing therapeutically effective amounts of the extracts of Aphanamixis polystachya in combination with other known anti-inflammatory agents useful for oral, parenteral and topical administration.

摘要翻译： 本发明公开了从植物来源制备的5-脂氧合酶抑制产物。 更具体地，本发明描述了5-脂氧合酶抑制性提取物或生物富集的提取物或聚山梨酸酯的部分，制备5-脂氧合酶抑制性提取物的方法，以及通过使用所述的方法治疗和/或预防5-脂氧合酶介导的疾病状态的方法 提取。 本发明进一步公开了药物或营养学或膳食组合物，其含有治疗有效量的阿泊他尼斯多螨的提取物与用于口服，胃肠外和局部给药的其它已知抗炎药的组合。

公开(公告)号：US20100272678A1

公开(公告)日：2010-10-28

申请号：US12767647

申请日：2010-04-26

申请人： Ganga Raju GOKARAJU ,  Sudhakar Kasina ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Venkateswarlu Somepalli ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Sengupta Krishanu ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju GOKARAJU ,  Sudhakar Kasina ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Venkateswarlu Somepalli ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Sengupta Krishanu ,  Venkata Krishna Raju Alluri

IPC分类号： A61K38/20 ,  C07C245/12 ,  A61K31/655 ,  A61K33/24 ,  A61K39/395 ,  A61K38/21 ,  A61K38/19 ,  A61P35/00

CPC分类号： A61K31/655 ,  A61K38/193 ,  A61K38/20 ,  A61K38/21 ,  A61K45/06 ,  C07D253/04 ,  C07D517/14 ,  A61K2300/00

摘要： Selenopheno triazene analogs, their compositions, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts and mixtures thereof are useful for the treatment of metastatic malignant melanoma and other cancers. The selenopheno triazene analogs have the general formulae (I) or (II): wherein the substituents R1, R2, R3, R6, and R7 are as described in the specification. Other cancers include which may be treated with these compounds include, but are not limited to, malignant melanoma, leukemia, lymphomas (Hodgkins and non-Hodgkins), sarcomas (Ewing's sarcoma), brain tumors, central nervous system (CNS) metastases, gliomas, carcinomas such as breast cancer, prostate cancer, lung cancer (small cell and non-small cell), colon cancer, pancreatic cancer, Head and Neck cancers and oropharyngeal squamous cell carcinoma.

摘要翻译： 硒代苯三氮烯类似物，它们的组合物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物及其药学上可接受的盐和混合物可用于治疗转移性恶性黑素瘤和其它癌症。 硒代苯并三氮烯类似物具有通式（I）或（II）：其中取代基R 1，R 2，R 3，R 6和R 7如说明书中所述。 可以用这些化合物治疗的其它癌症包括但不限于恶性黑素瘤，白血病，淋巴瘤（霍奇金淋巴瘤和非霍奇金淋巴瘤），肉瘤（尤文氏肉瘤），脑肿瘤，中枢神经系统（CNS）转移瘤，胶质瘤 ，癌症如乳腺癌，前列腺癌，肺癌（小细胞和非小细胞），结肠癌，胰腺癌，头颈部癌症和口咽鳞状细胞癌。

公开(公告)号：US09101599B2

公开(公告)日：2015-08-11

申请号：US13062066

申请日：2009-09-14

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

IPC分类号： A61K36/324

CPC分类号： A61K36/324

摘要： The present invention discloses synergistic nutraceutical or pharmaceutical or dietary supplement anti-inflammatory compositions comprising therapeutically effective combination of an extract selectively enriched in 3-O-acetyl-11-keto-β-boswellic acid (AKBA) derived from Boswellia serrata and Boswellia serrata non- acidic resin extract (BNRE). The composition(s) can be used to prevent, control and treat inflammation and several inflammatory related diseases including asthma, osteoarthritis, rheumatoid arthritis, endothelial dysfunction and the like. The invention further discloses the amelioration of pro-inflammator biomarker proteins or molecules, whose expression/production is altered during inflammatory diseases.

摘要翻译： 本发明公开了协同营养药物或药物或膳食补充剂抗炎组合物，其包含选自富含源于乳香乳杆菌（Boswellia serrata）和乳香型乳杆菌（Boswellia serrata）的3-O-乙酰基-11-酮 - 巴豆酸（AKBA） 非酸性树脂提取物（BNRE）。 组合物可用于预防，控制和治疗炎症和若干炎性相关疾病，包括哮喘，骨关节炎，类风湿性关节炎，内皮功能障碍等。 本发明还公开了改善炎症性疾病期间其表达/产生被改变的促炎剂生物标记蛋白或分子。

公开(公告)号：US08143237B2

公开(公告)日：2012-03-27

申请号：US12767647

申请日：2010-04-26

申请人： Ganga Raju Gokaraju ,  Sudhakar Kasina ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Venkateswarlu Somepalli ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Sengupta Krishanu ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju Gokaraju ,  Sudhakar Kasina ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Venkateswarlu Somepalli ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Sengupta Krishanu ,  Venkata Krishna Raju Alluri

IPC分类号： C07D517/04 ,  A61K31/53 ,  A61K31/655 ,  A61P31/00

CPC分类号： A61K31/655 ,  A61K38/193 ,  A61K38/20 ,  A61K38/21 ,  A61K45/06 ,  C07D253/04 ,  C07D517/14 ,  A61K2300/00

摘要： Selenopheno triazene analogs, their compositions, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts and mixtures thereof are useful for the treatment of metastatic malignant melanoma and other cancers. The selenopheno triazene analogs have the general formulae (I) or (II): wherein the substituents R1, R2, R3, R6, and R7 are as described in the specification. Other cancers include which may be treated with these compounds include, but are not limited to, malignant melanoma, leukemia, lymphomas (Hodgkins and non-Hodgkins), sarcomas (Ewing's sarcoma), brain tumors, central nervous system (CNS) metastases, gliomas, carcinomas such as breast cancer, prostate cancer, lung cancer (small cell and non-small cell), colon cancer, pancreatic cancer, Head and Neck cancers and oropharyngeal squamous cell carcinoma.

摘要翻译： 硒代苯三氮烯类似物，它们的组合物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物及其药学上可接受的盐和混合物可用于治疗转移性恶性黑素瘤和其它癌症。 硒代苯并三氮烯类似物具有通式（I）或（II）：其中取代基R 1，R 2，R 3，R 6和R 7如说明书中所述。 可以用这些化合物治疗的其它癌症包括但不限于恶性黑素瘤，白血病，淋巴瘤（霍奇金淋巴瘤和非霍奇金淋巴瘤），肉瘤（尤文氏肉瘤），脑肿瘤，中枢神经系统（CNS）转移瘤，胶质瘤 ，癌症如乳腺癌，前列腺癌，肺癌（小细胞和非小细胞），结肠癌，胰腺癌，头颈部癌症和口咽鳞状细胞癌。

公开(公告)号：US20110159120A1

公开(公告)日：2011-06-30

申请号：US13062066

申请日：2009-09-14

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka,Ranga,Raju Gokaraju ,  Trimurtulu Golakoti ,  kiren Bhupathiraju ,  Venkata Krishna, Raju Alluri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka,Ranga,Raju Gokaraju ,  Trimurtulu Golakoti ,  kiren Bhupathiraju ,  Venkata Krishna, Raju Alluri

IPC分类号： A61K36/324 ,  A61P35/00 ,  A61P9/10 ,  A61P19/02 ,  A61P25/06 ,  A61P1/00 ,  A61P17/00 ,  A61P17/06 ,  A61P1/02

CPC分类号： A61K36/324

摘要： The present invention discloses synergistic nutraceutical or pharmaceutical or dietary supplement anti-inflammatory compositions comprising therapeutically effective combination of an extract selectively enriched in 3-O-acetyl-11-keto-β-boswellic acid (AKBA) derived from Boswellia serrata and Boswellia serrata non- acidic resin extract (BNRE). The composition(s) can be used to prevent, control and treat inflammation and several inflammatory related diseases including asthma, osteoarthritis, rheumatoid arthritis, endothelial dysfunction and the like. The invention further discloses the amelioration of pro-inflammator biomarker proteins or molecules, whose expression/production is altered during inflammatory diseases.

摘要翻译： 本发明公开了协同营养药物或药物或膳食补充剂抗炎组合物，其包含选自富含源于乳香乳杆菌（Boswellia serrata）和乳香型乳杆菌（Boswellia serrata）的3-O-乙酰基-11-酮 - 巴豆酸（AKBA） 非酸性树脂提取物（BNRE）。 组合物可用于预防，控制和治疗炎症和若干炎性相关疾病，包括哮喘，骨关节炎，类风湿性关节炎，内皮功能障碍等。 本发明还公开了改善炎症性疾病期间其表达/产生被改变的促炎剂生物标记蛋白或分子。

公开(公告)号：US09301987B2

公开(公告)日：2016-04-05

申请号：US12679826

申请日：2007-09-24

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Krishanu Sengupta ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Krishanu Sengupta ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

IPC分类号： A61K36/67 ,  A23L1/29 ,  A23L1/30 ,  A61K36/185 ,  A61K36/328 ,  A61K36/48 ,  A61K36/9068

CPC分类号： A61K36/67 ,  A23L33/105 ,  A23L33/30 ,  A61K36/185 ,  A61K36/328 ,  A61K36/48 ,  A61K36/9068 ,  A61K2300/00 ,  A61K36/42

摘要： Herbal compositions are useful for inhibition, amelioration or prevention of adipogenesis mediated diseases such as obesity, lipid storage disease and hyperlipemia. The herbal compositions comprise biologically effective amounts of extracts or fractions from Piper betle in combination with one or more of the extracts or fractions derived from Dolichos biflorus, Commiphora mukul, Boerhaavia diffusa, Tribulus terrestris and Zingiber officinale as active ingredients. The compositions optionally contain a bio-enhancing agent or a bio-protecting agent, along with biologically acceptable carriers or diluents. The herbal compositions may be used in a method for treating or preventing adipogenesis involved diseases in mammals.

摘要翻译： 草药组合物可用于抑制，改善或预防脂肪形成介导的疾病，例如肥胖症，脂质储存疾病和高脂血症。 草药组合物包含生物有效量的来自Pi le的提取物或级分与来自Dolichos biflorus，Commiphora mukul，Boerhaavia diffusa，Trib藜和Zingiber officinale的一种或多种提取物或级分的组合作为活性成分。 组合物任选地含有生物增强剂或生物保护剂，以及生物可接受的载体或稀释剂。 草药组合物可以用于治疗或预防脂肪形成涉及哺乳动物疾病的方法。

公开(公告)号：US20160074457A1

公开(公告)日：2016-03-17

申请号：US14951175

申请日：2015-11-24

申请人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIRAJU ,  Krishanu SENGUPTA ,  Venkata Krishna Raju ALLURI

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIRAJU ,  Krishanu SENGUPTA ,  Venkata Krishna Raju ALLURI

IPC分类号： A61K36/38 ,  A61K35/12 ,  A61K36/28

CPC分类号： A61K31/365 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/352 ,  A61K31/437 ,  A61K31/5377 ,  A61K35/12 ,  A61K36/28 ,  A61K36/38 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/21

摘要： Pharmaceutical/dietary supplements and food ingredient(s) derived from Sphaeranthus indicus are used for controlling or treating a metabolic disorder. The supplements and food ingredient(s) are selected from Sphaeranthus indicus extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.

摘要翻译： 来自Sphaeranthus indicus的药物/膳食补充剂和食物成分用于控制或治疗代谢紊乱。 补充剂和食品成分选自Sphaeranthus indicus提取物，级分，活性化合物和植物化学物质或其混合物及其组合物，优选与至少一种选自以下的组分组合： 提取物，部分，活性化合物和植物化学物质或其衍生自芒of藤的混合物。 成分和组成可用于控制，预防和治疗肥胖症，代谢综合征，糖尿病和其他代谢紊乱，并且还调节能量消耗，预防冠状动脉和腹主动脉中的动脉粥样硬化斑块，增加胰岛素 敏感性，改善葡萄糖耐量，降低甘油三酯水平和平衡哺乳动物中的葡萄糖水平。

公开(公告)号：US20100203117A1

公开(公告)日：2010-08-12

申请号：US12679826

申请日：2007-09-24

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Krishanu Sengupta ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Krishanu Sengupta ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

IPC分类号： A61K9/48 ,  A61K33/24 ,  A61K36/00 ,  A61K36/82 ,  A61K36/752 ,  A61K36/61 ,  A61K36/8962 ,  A61K36/906 ,  A61P3/00

CPC分类号： A61K36/67 ,  A23L33/105 ,  A23L33/30 ,  A61K36/185 ,  A61K36/328 ,  A61K36/48 ,  A61K36/9068 ,  A61K2300/00 ,  A61K36/42

摘要： Herbal compositions are useful for inhibition, amelioration or prevention of adipogenesis mediated diseases such as obesity, lipid storage disease and hyperlipemia. The herbal compositions comprise biologically effective amounts of extracts or fractions from Piper betle in combination with one or more of the extracts or fractions derived from Dolichos biflorus, Commiphora mukul, Boerhaavia diffusa, Tribulus terrestris and Zingiber officinale as active ingredients. The compositions optionally contain a bio-enhancing agent or a bio-protecting agent, along with biologically acceptable carriers or diluents. The herbal compositions may be used in a method for treating or preventing adipogenesis involved diseases in mammals.

摘要翻译： 草药组合物可用于抑制，改善或预防脂肪形成介导的疾病，例如肥胖症，脂质储存疾病和高脂血症。 草药组合物包含生物有效量的来自Pi le的提取物或级分与来自Dolichos biflorus，Commiphora mukul，Boerhaavia diffusa，Trib藜和Zingiber officinale的一种或多种提取物或级分的组合作为活性成分。 组合物任选地含有生物增强剂或生物保护剂，以及生物可接受的载体或稀释剂。 草药组合物可以用于治疗或预防脂肪形成涉及哺乳动物疾病的方法。