公开(公告)号：US20080095805A1

公开(公告)日：2008-04-24

申请号：US11575732

申请日：2005-09-21

申请人： Victor Lobanenkov ,  Dmitri Loukinov ,  Ziedulla Abdullaev ,  Svetlana Pack

发明人： Victor Lobanenkov ,  Dmitri Loukinov ,  Ziedulla Abdullaev ,  Svetlana Pack

IPC分类号： A61K39/00 ,  C07K16/00 ,  G01N33/53

CPC分类号： G01N33/57407

摘要： The invention provides a method comprising detecting autoantibodies to BORIS in a sample obtained from a mammal, as well as BORIS polypeptides and epitopes, and kits comprising the BORIS polypeptides and epitopes, and a method of inducing an immune response to BORIS in a mammal.

摘要翻译： 本发明提供了一种方法，其包括在从哺乳动物获得的样品中检测BORIS的自身抗体以及BORIS多肽和表位，以及包含BORIS多肽和表位的试剂盒，以及诱导哺乳动物对BORIS的免疫应答的方法。

公开(公告)号：US20050182249A1

公开(公告)日：2005-08-18

申请号：US10505377

申请日：2003-02-21

申请人： Victor Lobanenkov ,  Dmitri Loukinov ,  Herbert Morse

发明人： Victor Lobanenkov ,  Dmitri Loukinov ,  Herbert Morse

IPC分类号： A61K39/395 ,  A61K48/00 ,  C07H21/04 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/47 ,  C07K14/4702 ,  C12Q1/6886 ,  C12Q2600/106 ,  G01N33/57484

摘要： An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence that is complementary to a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; a vector comprising such an isolated or purified nucleic acid molecule; a cell comprising such a vector; an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; a cell line that produces a monoclonal antibody that is specific for an aforementioned isolated or purified polypeptide molecule; and the monoclonal antibody produced by the cell line; methods of diagnosing a cancer or a predisposition to a cancer in a male or female mammal; a method of prognosticating a cancer in a mammal; a method of assessing the effectiveness of treatment of a cancer in a mammal; a method of treating a mammal prophylactically or therapeutically for a cancer, and a composition comprising a carrier and an inhibitor of BORIS.

摘要翻译： 分离或纯化的核酸分子，主要由编码人或非人BORIS的核苷酸序列或前述任一种的片段组成; 基本上由与编码人或非人BORIS的核苷酸序列互补的核苷酸序列或前述任一种的片段组成的分离或纯化的核酸分子; 包含这种分离或纯化的核酸分子的载体; 包含这种载体的细胞; 基本上由编码人或非人BORIS的氨基酸序列或前述任一种的片段组成的分离或纯化的多肽分子; 产生对上述分离或纯化的多肽分子特异性的单克隆抗体的细胞系; 和由细胞系产生的单克隆抗体; 在男性或女性哺乳动物中诊断癌症或倾向于癌症的方法; 预测哺乳动物癌症的方法; 一种评估哺乳动物癌症治疗有效性的方法; 用于预防或治疗癌症的哺乳动物的方法，以及包含载体和BORIS抑制剂的组合物。