Brother of the regulator of imprinted sites (boris)
    2.
    发明申请
    Brother of the regulator of imprinted sites (boris) 有权
    兄弟的压印网站(boris)

    公开(公告)号:US20050182249A1

    公开(公告)日:2005-08-18

    申请号:US10505377

    申请日:2003-02-21

    摘要: An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence that is complementary to a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; a vector comprising such an isolated or purified nucleic acid molecule; a cell comprising such a vector; an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; a cell line that produces a monoclonal antibody that is specific for an aforementioned isolated or purified polypeptide molecule; and the monoclonal antibody produced by the cell line; methods of diagnosing a cancer or a predisposition to a cancer in a male or female mammal; a method of prognosticating a cancer in a mammal; a method of assessing the effectiveness of treatment of a cancer in a mammal; a method of treating a mammal prophylactically or therapeutically for a cancer, and a composition comprising a carrier and an inhibitor of BORIS.

    摘要翻译: 分离或纯化的核酸分子,主要由编码人或非人BORIS的核苷酸序列或前述任一种的片段组成; 基本上由与编码人或非人BORIS的核苷酸序列互补的核苷酸序列或前述任一种的片段组成的分离或纯化的核酸分子; 包含这种分离或纯化的核酸分子的载体; 包含这种载体的细胞; 基本上由编码人或非人BORIS的氨基酸序列或前述任一种的片段组成的分离或纯化的多肽分子; 产生对上述分离或纯化的多肽分子特异性的单克隆抗体的细胞系; 和由细胞系产生的单克隆抗体; 在男性或女性哺乳动物中诊断癌症或倾向于癌症的方法; 预测哺乳动物癌症的方法; 一种评估哺乳动物癌症治疗有效性的方法; 用于预防或治疗癌症的哺乳动物的方法,以及包含载体和BORIS抑制剂的组合物。