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公开(公告)号：US20120070461A1
公开(公告)日：2012-03-22
申请号：US13239011
申请日：2011-09-21
CPC分类号： G01N33/57419 , G01N33/5047 , G01N33/5743 , G01N33/57438 , G01N33/57446
摘要： The present invention relates to the use of myeloid cell biomarkers for the differential diagnosis, prognosis, and monitoring of renal cell carcinoma (RCC) or colorectal cancer (CRC). The present invention furthermore relates to monitoring the effect of a treatment against renal cell carcinoma (RCC) or colorectal cancer (CRC), and establishing a prognosis of the outcome of the treatment of renal cell carcinoma (RCC) or colorectal cancer (CRC). The present invention furthermore relates to panels of cellular biomarkers for use in the above methods, in particular multicolor panels for measuring said biomarkers.
摘要翻译： 本发明涉及骨髓细胞生物标志物用于肾细胞癌（RCC）或结肠直肠癌（CRC）的鉴别诊断，预后和监测的用途。 本发明还涉及监测针对肾细胞癌（RCC）或结肠直肠癌（CRC）的治疗效果，以及建立肾细胞癌（RCC）或结肠直肠癌（CRC）治疗结果的预后。 本发明还涉及用于上述方法的细胞生物标志物的面板，特别是用于测量所述生物标志物的多色面板。
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公开(公告)号：US20090074796A1
公开(公告)日：2009-03-19
申请号：US11794855
申请日：2006-01-09
IPC分类号： A61K39/00 , A61K31/519 , A61K31/4985
CPC分类号： A61K31/53 , A61K31/4985 , A61K31/519 , A61K39/0011 , A61K45/06 , G01N33/5091 , G01N2800/52 , A61K2300/00
摘要： The invention features methods and compositions featuring a PDE5 inhibitor for treating or preventing immunological-mediated disease in a subject.
摘要翻译： 本发明的特征在于用于治疗或预防受试者中免疫介导的疾病的PDE5抑制剂的方法和组合物。
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公开(公告)号：US20120225038A1
公开(公告)日：2012-09-06
申请号：US13146823
申请日：2009-01-28
CPC分类号： C12N5/0647 , A61K35/28
摘要： A population of myeloid-derived suppressor cells and the culture procedure to obtain these in vitro starting with bone marrow cells of mice, other animals and human beings, in the presence of specific cytokine combinations used to determine concentrations, is provided.
摘要翻译： 提供了一种骨髓来源的抑制细胞群体，以及在用于确定浓度的特异性细胞因子组合存在下从小鼠，其他动物和人的骨髓细胞开始体外获得这些细胞的培养方法。
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