公开(公告)号：US20050203086A1

公开(公告)日：2005-09-15

申请号：US10793530

申请日：2004-03-04

Applicant: Alexander Constan ,  Prakash Keshary ,  David MacLean ,  Vishwas Paralkar ,  Doina Roman ,  David Thompson ,  Timothy Wright

Inventor： Alexander Constan ,  Prakash Keshary ,  David MacLean ,  Vishwas Paralkar ,  Doina Roman ,  David Thompson ,  Timothy Wright

IPC: A61K31/4245 ,  A61K31/433 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541

CPC classification number: A61K31/00 ,  A61K31/197 ,  A61K31/277 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4045 ,  A61K31/4164 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4406 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/5377

Abstract: The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

Abstract translation: 本发明涉及治疗肺动脉高压，促进关节融合，促进肌腱和韧带修复，减少二次骨折的发生，治疗无血管性坏死，促进软骨修复，促进肢体移植后骨愈合，促进肝再生，促进伤口愈合的方法 ，减少胃溃疡的发生，治疗高血压，促进牙釉质或手指或脚趾指甲的生长，治疗青光眼，治疗高眼压症和使用EP 2选择性修复由转移性骨病引起的损伤 受体激动剂。