公开(公告)号：US08608695B2

公开(公告)日：2013-12-17

申请号：US13413103

申请日：2012-03-06

Applicant: Marius Hauri ,  Frank Blinkhorn ,  David MacLean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

Inventor： Marius Hauri ,  Frank Blinkhorn ,  David MacLean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

IPC: A61M5/00

CPC classification number: A61M5/3202 ,  A61M5/3216 ,  A61M5/50 ,  A61M2005/3217 ,  A61M2205/6081

Abstract: A safety needle assembly has a collar or ring that is rotatably mounted to a needle hub. The needle assembly may be connected to a syringe by the user grasping the needle hub in first and second embodiments, or turning of the needle sheath in other embodiments. The collar of the needle assembly may be rotated by turning the needle sheath. The needle hub may also interact with the collar by rotating the needle sheath. Mechanisms are provided at both the collar and the housing so that once the contaminated needle is covered, the needle assembly may be removed from the syringe for disposal by rotating the needle housing.

Abstract translation: 安全针组件具有可旋转地安装到针座的套环或环。 在其它实施例中，针组件可以通过使用者在第一和第二实施例中抓住针座来进行连接，或者在其他实施例中转动针鞘。 可以通过转动针套来旋转针组件的套环。 针座也可以通过旋转针鞘与套环相互作用。 在轴环和壳体两端提供机构，使得一旦被污染的针被覆盖，针组件可以从注射器中取出，以通过旋转针壳来处置。

公开(公告)号：US08603042B2

公开(公告)日：2013-12-10

申请号：US13137294

申请日：2011-08-04

Applicant: Robert Simas, Jr. ,  David MacLean

Inventor： Robert Simas, Jr. ,  David MacLean

IPC: A61M5/32 ,  A61M5/00

CPC classification number: A61M5/3216 ,  A61M5/3202 ,  A61M2005/3217 ,  Y10T29/49 ,  Y10T29/49826

Abstract: The present invention safety device is a one-piece needle assembly that has a base and a housing pivotally connected to the base. The base has a distal portion to which a needle is fitted. At the base there is formed longitudinally along its distal portion a catch mechanism that may be in the form of an anchor projection. At the back wall of the housing there is extended another catch mechanism that may be configured in the form of two clasping fingers. Also providing in the housing is an integral hook. As the housing and the base are pivoted relative to each other, and as the needle makes contact with the hook, the respective catch mechanisms at the base and the housing also make contact with each other, resulting in the coupling of the catch mechanisms and the coupling of the needle to the hook. As a result, the catch mechanisms are interlocked and the needle is fixedly retained by the hook within the housing. The catch mechanisms may also be configured as a hook and a latch in the form of a rib with an opening whereto the hook is fixedly coupled. The catch mechanisms may further be configured as respective interlockable pairs of loops and bosses. The gauge of the needle may be determined by the color of both the base and the housing, which are molded as a unitary single unit.

Abstract translation: 本发明的安全装置是一体式针组件，其具有基部和枢转地连接到基座的壳体。 底座具有一个远端部分，针头装配到该远端部分。 在基部处，沿着其远端部分纵向地形成可以是锚定突起的形式的捕捉机构。 在壳体的后壁处延伸另一个可以被配置成两个扣紧手指形式的止动机构。 在外壳中也提供了一个整体的钩子。 当壳体和基座相对于彼此枢转时，并且当针与钩接触时，基部和壳体处的相应的卡止机构也彼此接触，导致卡扣机构和 针与钩的耦合。 结果，锁定机构是互锁的，并且针被壳体内的钩固定地保持。 捕获机构还可以被配置为具有开口的肋形式的钩和闩锁，钩子固定地联接在该开口上。 捕获机构还可以被配置为各自可互锁的环和凸起对。 针的尺寸可以由基座和外壳的颜色确定，这两种颜色被模制成一体的单一单元。

公开(公告)号：US08152761B2

公开(公告)日：2012-04-10

申请号：US10832339

申请日：2004-04-27

Applicant: Marius Hauri ,  Frank Blinkhorn ,  David MacLean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

Inventor： Marius Hauri ,  Frank Blinkhorn ,  David MacLean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

IPC: A61M5/00

CPC classification number: A61M5/3202 ,  A61M5/3216 ,  A61M5/50 ,  A61M2005/3217 ,  A61M2205/6081

Abstract: A safety needle assembly has a collar or ring that is rotatably mounted to a needle hub, which may be connected to a medical device such as a syringe. The needle assembly may be connected to the syringe by the user grasping the needle hub in first and second embodiments, or turning of the needle sheath in other embodiments. In all of the embodiments, the collar of the needle assembly may be rotated by turning the needle sheath, which is designed to interact with the collar. In some of the embodiments, the needle hub likewise interacts with the collar in such a way that by rotating the needle sheath, the needle hub is likewise rotated for connection to a syringe. When an exposed needle is to be covered, after the needle sheath has been removed, a housing connected to the collar is pivotally moved to cover the needle. Mechanisms are provided at both the collar and the housing so that once the contaminated needle is covered, the needle assembly may be removed from the syringe for disposal by rotating the needle housing. In all of the embodiments disclosed, the needle sheath does not come into contact with the needle hub and the collar is rotatable about the needle hub.

Abstract translation: 安全针组件具有可旋转地安装到针座的套环或环，所述针座可以连接到例如注射器的医疗装置。 在其它实施例中，针组件可以通过在第一和第二实施例中抓住针座的用户连接到注射器，或者在其他实施例中可以转动针鞘。 在所有实施例中，可以通过转动设计成与套环相互作用的针护套来旋转针组件的套环。 在一些实施例中，针毂同样地以这样的方式与套环相互作用，即通过旋转针鞘，针座同样被旋转以连接到注射器。 当外露针头被覆盖时，在鞘鞘被移除之后，连接到套环的壳体被枢转地移动以覆盖针头。 在轴环和壳体两端提供机构，使得一旦被污染的针被覆盖，针组件可以从注射器中取出，以通过旋转针壳来处置。 在所公开的所有实施例中，针护套不与针座接触，并且套环可围绕针毂旋转。

公开(公告)号：US20080256429A1

公开(公告)日：2008-10-16

申请号：US11777957

申请日：2007-07-13

Applicant: Terry Wayne PENNER ,  Francis Wai Gee LUI ,  Wai Sing WANG ,  Michael Akio TSUMURA ,  David MACLEAN

Inventor： Terry Wayne PENNER ,  Francis Wai Gee LUI ,  Wai Sing WANG ,  Michael Akio TSUMURA ,  David MACLEAN

IPC: G06F17/00 ,  G06Q10/00

CPC classification number: G06F17/248

Abstract: A computer readable storage medium comprises a publication definition module to create and define properties for a publication object. The publication definition module includes executable instructions to associate a set of static documents and a set of report templates with the publication object. Executable instructions define a conditional delivery rule for the publication object. The conditional delivery rule specifies a condition for the inclusion of a report template from the set of report templates to be merged with a static document from the set of static documents.

Abstract translation: 计算机可读存储介质包括用于创建和定义出版物对象的属性的发布定义模块。 发布定义模块包括将一组静态文档和一组报告模板与发布对象相关联的可执行指令。 可执行指令为发布对象定义条件传递规则。 条件传递规则指定了从报告模板集合中包含报告模板的条件，以便与静态文档集合中的静态文档合并。

公开(公告)号：US20050203086A1

公开(公告)日：2005-09-15

申请号：US10793530

申请日：2004-03-04

Applicant: Alexander Constan ,  Prakash Keshary ,  David MacLean ,  Vishwas Paralkar ,  Doina Roman ,  David Thompson ,  Timothy Wright

Inventor： Alexander Constan ,  Prakash Keshary ,  David MacLean ,  Vishwas Paralkar ,  Doina Roman ,  David Thompson ,  Timothy Wright

IPC: A61K31/4245 ,  A61K31/433 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541

CPC classification number: A61K31/00 ,  A61K31/197 ,  A61K31/277 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4045 ,  A61K31/4164 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4406 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/5377

Abstract: The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

Abstract translation: 本发明涉及治疗肺动脉高压，促进关节融合，促进肌腱和韧带修复，减少二次骨折的发生，治疗无血管性坏死，促进软骨修复，促进肢体移植后骨愈合，促进肝再生，促进伤口愈合的方法 ，减少胃溃疡的发生，治疗高血压，促进牙釉质或手指或脚趾指甲的生长，治疗青光眼，治疗高眼压症和使用EP 2选择性修复由转移性骨病引起的损伤 受体激动剂。

公开(公告)号：US08251961B2

公开(公告)日：2012-08-28

申请号：US10665514

申请日：2003-09-22

Applicant: Marius Hauri ,  Frank Blinkhorn ,  David Maclean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

Inventor： Marius Hauri ,  Frank Blinkhorn ,  David Maclean ,  Lawrence P. Hudon ,  Robert Simas, Jr. ,  Troy M. Derby

IPC: A61M5/00

CPC classification number: A61M5/3202 ,  A61M5/3216 ,  A61M5/50 ,  A61M2005/3217 ,  A61M2205/6081

Abstract: A safety needle assembly has a needle hub and a collar. Integrally formed from the proximal portion of the needle hub is a ring that surrounds its luer base. At the distal portion of the needle hub there are coaxially formed circumferential flanges which act to allow the collar to be rotatable about the needle hub. A needle protection housing is connected to the collar and is pivotable to cover the needle that extends from the distal end of the needle hub. Before use, the needle extending from the needle hub is covered by a needle sheath that has a groove formed circumferentially at its proximal end that snap-fits to a circumferential rib formed at the distal end of the collar.

Abstract translation: 安全针组件具有针座和套环。 从针座的近侧部分整体形成的环绕其鲁尔底座。 在针座的远端部分处具有同轴形成的周向凸缘，其作用是允许套环围绕针毂可旋转。 针保护壳体连接到套环，并且可枢转以覆盖从针座的远端延伸的针。 在使用之前，从针座延伸的针被针护套覆盖，该针护套在其近端处具有周向形成的凹槽，该槽与形成在套环的远端处的周向肋卡扣配合。

公开(公告)号：US07992078B2

公开(公告)日：2011-08-02

申请号：US11777957

申请日：2007-07-13

Applicant: Terry Wayne Penner ,  Francis Wai Gee Lui ,  Wai Sing Wang ,  Michael Akio Tsumura ,  David MacLean

Inventor： Terry Wayne Penner ,  Francis Wai Gee Lui ,  Wai Sing Wang ,  Michael Akio Tsumura ,  David MacLean

IPC: G06F17/00

CPC classification number: G06F17/248

Abstract: A computer readable storage medium comprises a publication definition module to create and define properties for a publication object. The publication definition module includes executable instructions to associate a set of static documents and a set of report templates with the publication object. Executable instructions define a conditional delivery rule for the publication object. The conditional delivery rule specifies a condition for the inclusion of a report template from the set of report templates to be merged with a static document from the set of static documents.

Abstract translation: 计算机可读存储介质包括用于创建和定义出版物对象的属性的发布定义模块。 发布定义模块包括将一组静态文档和一组报告模板与发布对象相关联的可执行指令。 可执行指令为发布对象定义条件传递规则。 条件传递规则指定了从报告模板集合中包含报告模板的条件，以便与静态文档集合中的静态文档合并。

公开(公告)号：US20100327972A1

公开(公告)日：2010-12-30

申请号：US12495671

申请日：2009-06-30

Applicant: William David MacLean ,  Bruce Carl Larson

Inventor： William David MacLean ,  Bruce Carl Larson

IPC: H03F3/217

CPC classification number: H03K5/131 ,  H03K2005/00136

Abstract: A system, method and apparatus is provided for pulse width correction in a power driver. In an embodiment, an apparatus includes an operational amplifier having an input and an output. The input of the operational amplifier is coupled to receive an input pulse signal. The apparatus further includes an output stage having an input coupled to the output of the operational amplifier. The output stage also includes a current output configured to couple to a load and to a voltage sense output. The apparatus also includes a comparator having an inverting input coupled to the voltage sense output of the output stage, a non-inverting input configured to couple to an input signal, and an output. Also, the apparatus includes a timing circuit with an input coupled to the output of the comparator and an input coupled to the input signal. The timing circuit also has an output to supply the input pulse signal. The timing circuit measures a delay from a change in the input signal to a change in the output of the comparator. The timing circuit replicates the measured delay as a delay in a change to the input pulse signal.

Abstract translation: 在功率驱动器中提供用于脉冲宽度校正的系统，方法和装置。 在一个实施例中，一种装置包括具有输入和输出的运算放大器。 运算放大器的输入被耦合以接收输入脉冲信号。 该装置还包括具有耦合到运算放大器的输出的输入的输出级。 输出级还包括被配置为耦合到负载和电压感测输出的电流输出。 该装置还包括比较器，其具有耦合到输出级的电压检测输出的反相输入，被配置为耦合到输入信号的非反相输入和输出。 此外，该装置包括具有耦合到比较器的输出的输入和耦合到输入信号的输入的定时电路。 定时电路还具有输出以提供输入脉冲信号。 定时电路测量从输入信号的变化到比较器的输出变化的延迟。 定时电路将测量的延迟复制为对输入脉冲信号的改变的延迟。

公开(公告)号：US20100273661A1

公开(公告)日：2010-10-28

申请号：US12663311

申请日：2008-06-11

Applicant: Yang Qiu ,  Dilip Rajagopalan ,  Lei Zhu ,  Susan C Connor ,  Guanghui Hu ,  David Maclean ,  Doris Damian ,  Amir Handzel ,  Rajalakshmi Balasubramanian

Inventor： Yang Qiu ,  Dilip Rajagopalan ,  Lei Zhu ,  Susan C Connor ,  Guanghui Hu ,  David Maclean ,  Doris Damian ,  Amir Handzel ,  Rajalakshmi Balasubramanian

IPC: G01N33/92 ,  G01N33/68 ,  G01N33/48 ,  C12Q1/37 ,  G01N33/66 ,  G01N33/72 ,  C40B30/00 ,  G06F19/00 ,  A61B5/00

CPC classification number: G01N33/6893 ,  G01N2333/54 ,  G01N2800/042 ,  G06Q50/24 ,  G16B40/00 ,  Y10T436/143333 ,  Y10T436/144444 ,  Y10T436/201666 ,  Y10T436/203332

Abstract: A method for predicting treatment response of a type II diabetes patient to rosiglitazone is provided. The method involves at least one sample from a patient having type II diabetes and analyzing biomarkers predictive of a patient who will respond to treatment with rosiglitazone. The biomarkers include, at least, interleukin-8, histidine, citrate. These biomarkers are identified in at least one classification analyses selected from the group consisting of a majority-vote based classifier and support-vector machine (SVM) classifier. Also provided is a method for predicting treatment response of a type II diabetes patient to glyburide at 8 weeks post-initiation of therapy. The method involves obtaining a sample from a type II diabetes patient who has been treated with glyburide for about 4 weeks and analyzing biomarkers predictive of a patient who will respond to treatment with glyburide at 8 weeks. The biomarkers useful in this method include, at least, sphingomyelin 23:1 and L-phenylalanine. Also provided are kits useful for the methods of the invention.

Abstract translation: 提供了预测II型糖尿病患者对罗格列酮治疗反应的方法。 该方法涉及来自患有II型糖尿病的患者的至少一种样品，并分析预测将对罗格列酮治疗作出反应的患者的生物标志物。 生物标志物至少包括白细胞介素-8，组氨酸，柠檬酸盐。 这些生物标志物在至少一种选自基于多数投票的分类器和支持向量机（SVM）分类器的分类分析中被鉴定。 还提供了用于在开始治疗后8周预测II型糖尿病患者对格列本脲的治疗反应的方法。 该方法包括从已经用格列本脲治疗约4周的II型糖尿病患者获得样品，并分析预测在8周时对格列本脲治疗作出反应的患者的生物标志物。 在该方法中有用的生物标志物至少包括鞘磷脂23：1和L-苯丙氨酸。 还提供了可用于本发明方法的试剂盒。

公开(公告)号：US06997916B2

公开(公告)日：2006-02-14

申请号：US10749514

申请日：2004-01-02

Applicant: Robert Simas, Jr. ,  David MacLean

Inventor： Robert Simas, Jr. ,  David MacLean

IPC: A61B19/00

CPC classification number: A61J1/2096 ,  A61B10/0045 ,  A61J1/201 ,  A61J1/2055 ,  Y10S604/905

Abstract: A fluid transfer system has a holder that is made of a cylindrical member having a closed end and an open end. The closed end has fitted thereto a luer and a cannula that extends into the interior of the holder. The holder has a distal portion that has a first cross section and a proximal portion that has a second cross section. The cross section of the distal portion is smaller than the cross section of the proximal portion. The distal and proximal portions are joined by a shoulder. The fluid transfer system also includes an adapter that is inserted to the holder from the open end of the holder. The adapter has a base having a central opening and a cylindrical tube that extends from the central opening. The diameter of the cylindrical tube is slightly smaller than the diameter of the distal portion and is configured to accept a first type of fluid collection store such as a vacuum tube. With the adapter removed, the holder can accept a differently dimensioned fluid collection store such as for example a blood culture collection bottle.

Abstract translation: 流体输送系统具有由具有封闭端和开口端的圆柱形构件制成的保持器。 封闭的端部装配有延伸到保持器内部的路厄尔和套管。 保持器具有具有第一横截面的远端部分和具有第二横截面的近端部分。 远侧部分的横截面小于近端部分的横截面。 远端和近端部分由肩部连接。 流体输送系统还包括从保持器的开口端插入到保持器中的适配器。 适配器具有具有中心开口的基部和从中心开口延伸的圆柱形管。 圆柱形管的直径略小于远端部分的直径，并且构造成接受第一类型的流体收集储存器，例如真空管。 随着适配器被移除，保持器可以接受不同尺寸的流体收集储存器，例如血液培养收集瓶。