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公开(公告)号：US20220381698A1
公开(公告)日：2022-12-01
申请号：US17875473
申请日：2022-07-28
Applicant: Vision Diagnostics, Inc.
Inventor： Jerry W. Denney
IPC: G01N21/78 , G01N33/493 , G01N33/487 , C12Q1/42
Abstract: The problem of detecting whether a urine sample is true human urine or a counterfeit urine product is solved by the use of reagent systems that detect two markers normally present in human urine. The markers acid phosphatase and alkaline phosphatase catalyze the substrates thymolphthalein monophosphate and p-nitrophenol phosphate, respectively. These substrates are formulated as spot tests on a dip stick or as reagents for use in automated chemical analyzers. The presence of the markers can be qualitatively detected by color-changes in the sample, formed by the pH-specific chromogens that result from catalysis of the substrates with the markers. The control reagent can further indicate whether a counterfeit urine product contains one or both of the chromogens.
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公开(公告)号：US11493497B1
公开(公告)日：2022-11-08
申请号：US16226768
申请日：2018-12-20
Applicant: Vision Diagnostics, Inc.
Inventor： Jerry W. Denney
IPC: G01N33/487 , G01N33/539 , G01N33/537 , G01N33/52 , G01N33/493
Abstract: Assays and methods for verifying the validity of a urine sample submitted for Drugs of Abuse (DOA) testing. Embodiments include a SUD Diagnostic Panel that includes six assays: specific gravity index assay, long-duration counterfeit urine assay, short-duration counterfeit urine assay, oxidant history assay, pH assay, and creatinine assay. The SUD Diagnostic Panel detects twelve principle classes of adulteration. Detection of adulteration of one or more urine samples from a patient indicates an attempt to subvert test results and provides an objective indication in one instance and an object diagnosis in another instance of SUD.
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公开(公告)号：US10571457B2
公开(公告)日：2020-02-25
申请号：US16139802
申请日：2018-09-24
Applicant: Vision Diagnostics, Inc.
Inventor： Jerry W. Denney
IPC: G01N33/493 , G01N21/78 , G01N21/31
Abstract: The problem of confirming the presence of an adulterant in a urine sample is solved by the use of a reagent capable of reacting with uric acid and non-urate markers in a urine sample. In one embodiment, a phosphotungtate reagent is used to react with the urine sample to create a blue coloration in the presence of uric acid or uric acid equivalents. A reduction or elimination of the blue coloration, resulting in a reduction in the light absorbance, of the urine sample can be used as an indicator of the historical presence of an adulterant. An Oxidant History test can also be generated using the phosphostungtate reagent, wherein the light absorbance resulting from the blue coloration is measured over time, with a measured reduction in the absorbance being an indication that an adulterant is or has been present in the urine sample and is oxidizing the uric acid and non-urate markers over time.
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4.发明申请公开(公告)号：US20180127799A1
公开(公告)日：2018-05-10
申请号：US15651334
申请日：2017-07-17
Applicant: Vision Diagnostics, Inc.
Inventor： Jerry W. Denney
IPC: C12Q1/34
CPC classification number: C12Q1/34 , G01N33/94 , G01N2333/938
Abstract: Reagents and methods for using automated laboratory equipment to determine whether the specific gravity of a urine sample is out of normal range as an indication of adulteration. The sodium (Na+) and potassium (K+) normally found in a urine sample can be used as markers. A sodium-potassium dependent β-galactosidase can be utilized with o-nitrophenylgalactoside (o-NPG) which is cleaved into o-nitrophenol, which turns the sample yellow. The sample can be analyzed by spectrophotometry methods utilized in most clinical analyzers at a pre-determined primary wavelength to obtain a Specific gravity Index (SGI). Measurements of the SGI that are outside a known normal range can indicate that the sample integrity has been compromised.
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公开(公告)号：US20170269058A1
公开(公告)日：2017-09-21
申请号：US15462157
申请日：2017-03-17
Applicant: Vision Diagnostics, Inc.
Inventor： Jerry W. Denney
IPC: G01N33/493 , G01N21/31 , G01N21/78
CPC classification number: G01N33/493 , G01N21/3103 , G01N21/78 , Y10T436/148888 , Y10T436/16
Abstract: The problem of confirming the presence of an adulterant in a urine sample is solved by the use of a reagent capable of reacting with uric acid and non-urate markers in a urine sample. In one embodiment, a phosphotungtate reagent is used to react with the urine sample to create a blue coloration in the presence of uric acid or uric acid equivalents. A reduction or elimination of the blue coloration, resulting in a reduction in the light absorbance, of the urine sample can be used as an indicator of the historical presence of an adulterant. An Oxidant History test can also be generated using the phosphostungtate reagent, wherein the light absorbance resulting from the blue coloration is measured over time, with a measured reduction in the absorbance being an indication that an adulterant is or has been present in the urine sample and is oxidizing the uric acid and non-urate markers over time.
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Patent Agency Ranking
公开(公告)号：US20170224212A1
公开(公告)日：2017-08-10
申请号：US15409299
申请日：2017-01-18
Applicant: Brien Holden Vision Diagnostics, Inc.
Inventor： Tom N. Cornsweet , Paul R. Peterson
CPC classification number: A61B3/12 , A61B3/0008 , A61B3/0025 , A61B3/103 , A61B3/14 , G02B7/09 , G02B27/0068
Abstract: An ocular fundus camera system and an associated methodology. The system includes (a) an image sensor disposed along a fundus-image reflection path adjacent that path's downstream end, and in optical communication with light carried in this path, (b) an aperture centered on the reflection path's long axis, operatively associated with, and stationary with respect to, the sensor at a location which is upstream from the sensor, and (c), for accomplishing (1) precision fundus-image focusing on the sensor, and additionally (2) autorefraction, optical, light-content shifting structure, operable selectively for producing, within that portion of the reflection path which is disposed downstream from the shifting structure, relative trans-axial displacement solely of any non-collimated light carried in that portion of the main path which is disposed upstream from the shifting structure.
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公开(公告)号：US09579018B2
公开(公告)日：2017-02-28
申请号：US14974947
申请日：2015-12-18
Applicant: Brien Holden Vision Diagnostics, Inc.
Inventor： Tom N. Cornsweet , Paul R. Peterson
CPC classification number: A61B3/12 , A61B3/0008 , A61B3/0025 , A61B3/103 , A61B3/14 , G02B7/09 , G02B27/0068
Abstract: An ocular fundus camera system and an associated methodology. The system includes (a) an image sensor disposed along a fundus-image reflection path adjacent that path's downstream end, and in optical communication with light carried in this path, (b) an aperture centered on the reflection path's long axis, operatively associated with, and stationary with respect to, the sensor at a location which is upstream from the sensor, and (c), for accomplishing (1) precision fundus-image focusing on the sensor, and additionally (2) autorefraction, optical, light-content shifting structure, operable selectively for producing, within that portion of the reflection path which is disposed downstream from the shifting structure, relative trans-axial displacement solely of any non-collimated light carried in that portion of the main path which is disposed upstream from the shifting structure.
Abstract translation: 眼底照相机系统和相关方法。 该系统包括（a）沿着邻近该路径的下游端的眼底图像反射路径设置的图像传感器，并且与该路径中携带的光光学通信，（b）以反射路径的长轴为中心的孔，可操作地与 并且相对于位于传感器上游的位置处的传感器静止，以及（c）用于完成（1）精确的基底图像聚焦在传感器上，以及另外（2）自动折射，光学，光内容 可移动结构，可选择性地用于在设置在移动结构的下游的反射路径的该部分内产生仅在主路径的该部分中承载的任何非准直光的相对跨轴位移， 移动结构。
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公开(公告)号：US20160100757A1
公开(公告)日：2016-04-14
申请号：US14974947
申请日：2015-12-18
Applicant: Brien Holden Vision Diagnostics, Inc.
Inventor： Tom N. Cornsweet , Paul R. Peterson
CPC classification number: A61B3/12 , A61B3/0008 , A61B3/0025 , A61B3/103 , A61B3/14 , G02B7/09 , G02B27/0068
Abstract: An ocular fundus camera system and an associated methodology. The system includes (a) an image sensor disposed along a fundus-image reflection path adjacent that path's downstream end, and in optical communication with light carried in this path, (b) an aperture centered on the reflection path's long axis, operatively associated with, and stationary with respect to, the sensor at a location which is upstream from the sensor, and (c), for accomplishing (1) precision fundus-image focusing on the sensor, and additionally (2) autorefraction, optical, light-content shifting structure, operable selectively for producing, within that portion of the reflection path which is disposed downstream from the shifting structure, relative trans-axial displacement solely of any non-collimated light carried in that portion of the main path which is disposed upstream from the shifting structure.
Abstract translation: 眼底照相机系统和相关方法。 该系统包括（a）沿着邻近该路径的下游端的眼底图像反射路径设置的图像传感器，并且与该路径中携带的光光学通信，（b）以反射路径的长轴为中心的孔，可操作地与 并且相对于位于传感器上游的位置处的传感器静止，以及（c）用于完成（1）精确的基底图像聚焦在传感器上，以及另外（2）自动折射，光学，光内容 可移动结构，可选择性地用于在设置在移动结构的下游的反射路径的该部分内产生仅在主路径的该部分中承载的任何非准直光的相对跨轴位移， 移动结构。
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公开(公告)号：US11214821B2
公开(公告)日：2022-01-04
申请号：US15651334
申请日：2017-07-17
Applicant: Vision Diagnostics, Inc.
Inventor： Jerry W. Denney
Abstract: Reagents and methods for using automated laboratory equipment to determine whether the specific gravity of a urine sample is out of normal range as an indication of adulteration. The sodium (Na+) and potassium (K+) normally found in a urine sample can be used as markers. A sodium-potassium dependent β-galactosidase can be utilized with o-nitrophenylgalactoside (o-NPG) which is cleaved into o-nitrophenol, which turns the sample yellow. The sample can be analyzed by spectrophotometry methods utilized in most clinical analyzers at a pre-determined primary wavelength to obtain a Specific gravity Index (SGI). Measurements of the SGI that are outside a known normal range can indicate that the sample integrity has been compromised.
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公开(公告)号：US10082495B2
公开(公告)日：2018-09-25
申请号：US15462157
申请日：2017-03-17
Applicant: Vision Diagnostics, Inc.
Inventor： Jerry W. Denney
IPC: G01N21/31 , G01N21/78 , G01N33/493
CPC classification number: G01N33/493 , G01N21/3103 , G01N21/78 , Y10T436/148888 , Y10T436/16
Abstract: The problem of confirming the presence of an adulterant in a urine sample is solved by the use of a reagent capable of reacting with uric acid and non-urate markers in a urine sample. In one embodiment, a phosphotungtate reagent is used to react with the urine sample to create a blue coloration in the presence of uric acid or uric acid equivalents. A reduction or elimination of the blue coloration, resulting in a reduction in the light absorbance, of the urine sample can be used as an indicator of the historical presence of an adulterant. An Oxidant History test can also be generated using the phosphostungtate reagent, wherein the light absorbance resulting from the blue coloration is measured over time, with a measured reduction in the absorbance being an indication that an adulterant is or has been present in the urine sample and is oxidizing the uric acid and non-urate markers over time.
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