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公开(公告)号：US20240327898A1
公开(公告)日：2024-10-03
申请号：US18741014
申请日：2024-06-12
申请人： VosBio, Inc.
IPC分类号： C12Q1/6806 , A61B10/00 , C12N15/10
CPC分类号： C12Q1/6806 , A61B10/0051 , C12N15/1003
摘要： Methods, devices and kits for sampling, releasing and stabilizing nucleic acid, including RNA and DNA, from virus, bacteria yeast and other cells is described. The released and stabilized nucleic acid may be analyzed and quantified without further sample preparation at the point of care or may be transported to a testing laboratory by shipment and analyzed directly. The nucleic acid, which can be RNA, remains safe and stable so that shipping by normal means including government postal service may be used. In addition, the RNA sample remains stable so that analysis can be performed immediately after receipt of sample or after storage for days, weeks or months. Storage may be at room or ambient temperature or cooler temperatures. The sampling apparatus used to acquire samples can interface with nucleic detection and measurement instrumentation including high throughput, parallel processing instruments.
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公开(公告)号：US12037633B2
公开(公告)日：2024-07-16
申请号：US17231234
申请日：2021-04-15
申请人： VosBio, Inc.
IPC分类号： C12Q1/6806 , A61B10/00 , C12N15/10
CPC分类号： C12Q1/6806 , A61B10/0051 , C12N15/1003
摘要： Methods, devices and kits for sampling, releasing and stabilizing nucleic acid, including RNA and DNA, from virus, bacteria yeast and other cells is described. The released and stabilized nucleic acid may be analyzed and quantified without further sample preparation at the point of care or may be transported to a testing laboratory by shipment and analyzed directly. The nucleic acid, which can be RNA, remains safe and stable so that shipping by normal means including government postal service may be used. In addition, the RNA sample remains stable so that analysis can be performed immediately after receipt of sample or after storage for days, weeks or months. Storage may be at room or ambient temperature or cooler temperatures. The sampling apparatus used to acquire samples can interface with nucleic detection and measurement instrumentation including high throughput, parallel processing instruments.
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公开(公告)号：US20210355525A1
公开(公告)日：2021-11-18
申请号：US17231234
申请日：2021-04-15
申请人： VosBio, Inc.
IPC分类号： C12Q1/6806 , C12N15/10 , A61B10/00
摘要： Methods, devices and kits for sampling, releasing and stabilizing nucleic acid, including RNA and DNA, from virus, bacteria yeast and other cells is described. The released and stabilized nucleic acid may be analyzed and quantified without further sample preparation at the point of care or may be transported to a testing laboratory by shipment and analyzed directly. The nucleic acid, which can be RNA, remains safe and stable so that shipping by normal means including government postal service may be used. In addition, the RNA sample remains stable so that analysis can be performed immediately after receipt of sample or after storage for days, weeks or months. Storage may be at room or ambient temperature or cooler temperatures. The sampling apparatus used to acquire samples can interface with nucleic detection and measurement instrumentation including high throughput, parallel processing instruments.
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公开(公告)号：US20240301519A1
公开(公告)日：2024-09-12
申请号：US18180414
申请日：2023-03-08
申请人： VosBio, Inc.
CPC分类号： C12Q1/701 , A61B5/097 , G01N1/2214 , C12Q1/6806 , C12Q1/6844 , G01N2001/2244 , G01N2001/2282
摘要： Breath liquid particles and vapor are captured in a device presenting a surface and chamber space that condenses or freezes the vapor and aerosol particulates. One or more breaths are exhaled through the device. Capture can be performed on the freezing surface immobilizing water upon contact. The chamber space within the device may freeze or condense liquid breath particles and vapor to collect them. After collection, the liquid is gathered and collected either by draining, scraping, pushing, or centrifugal force. The liquid may be collected and combined with a sample preparation reagent such as a virus lysing reagent, an internal standard, etc. After collection, the sample is analyzed. Analysis may be performed by PCR, qPCR RT-PCR, RT-qPCR, LAMP, RPA or any nucleic acid detection method, lateral antigen mass spectrometry, spectrophotometry or any analytical tool or method. Nucleic acid amplification reagents may contain a lysing reagent such as acetonitrile.
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公开(公告)号：US20240301491A1
公开(公告)日：2024-09-12
申请号：US18180400
申请日：2023-03-08
申请人： VosBio, Inc.
IPC分类号： C12Q1/6881 , A61B5/097 , C12Q1/6844
CPC分类号： C12Q1/6881 , A61B5/097 , C12Q1/6844
摘要： Breath liquid particles and vapor are captured in a device presenting a surface and chamber space that condenses or freezes the vapor and aerosol particulates. One or more breaths are exhaled through the device. Capture can be performed on the freezing surface immobilizing water upon contact. The chamber space within the device may freeze or condense liquid breath particles and vapor to collect them. After collection, the liquid is gathered and collected either by draining, scraping, pushing, or centrifugal force. The liquid may be collected and combined with a sample preparation reagent such as a virus lysing reagent, an internal standard, etc. After collection, the sample is separated into a plurality of independently analyzable units for detection and quantification of a target. Analysis may be performed by PCR, qPCR RT-PCR, RT-qPCR, LAMP, RPA or any nucleic acid detection method, lateral antigen mass spectrometry, spectrophotometry or any analytical tool or method. Nucleic acid amplification reagents may contain a lysing reagent such as acetonitrile.
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公开(公告)号：US20230091650A1
公开(公告)日：2023-03-23
申请号：US17932772
申请日：2022-09-16
申请人： VosBio, Inc.
摘要： Breath liquid particles and vapor are captured in a device presenting a surface and chamber space that condenses or freezes the vapor and aerosol particulates. One or more breaths are exhaled through the device. Capture can be performed on the freezing surface immobilizing water upon contact. The chamber space within the device may freeze liquid breath particles and vapor to collect them. After collection, the liquid is gathered and collected either by draining, pushing, or centrifugal force into a vial. The liquid may be collected and combined with a sample preparation reagent such as a virus lysing reagent, an internal standard, etc. After collection, the sample is analyzed. Analysis may be performed by PCR, qPCR RT-PCR, RT-qPCR, LAMP or any nucleic acid detection method, mass spectrometry, spectrophotometry or any analytical tool or method. Nucleic acid amplification reagents may contain a lysing reagent such as acetonitrile.
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