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公开(公告)号：US11517264B2
公开(公告)日：2022-12-06
申请号：US16483535
申请日：2018-02-06
发明人： Pramesh Kovoor , Jim Pouliopoulos , Tony Barry
IPC分类号： A61B5/0215 , A61B5/00 , A61B5/0245 , A61B5/11
摘要： A method of monitoring cardiac dysfunction, such as pericardial effusion, is disclosed. The method uses an indwelling probe inserted within a coronary sinus or a chamber or vessel of the heart, the probe having motion sensing means configured to sense motion of the probe based on movement of the wall of the coronary sinus or other chamber or vessel. Data is obtained from the motion sensing means and processed to monitor for cardiac dysfunction. The monitoring can be in real-time and can utilise one or more three-axis accelerometers. In some embodiments, two or more three-axis accelerometers are spaced longitudinally along an elongate body of the probe, which can increase accuracy and reliability of monitoring.
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公开(公告)号：US20220226373A1
公开(公告)日：2022-07-21
申请号：US16625443
申请日：2018-06-22
申请人： THE WESTMEAD INSTITUTE FOR MEDICAL RESEARCH , THE UNIVERSITY OF SYDNEY , WESTERN SYDNEY LOCAL HEALTH DISTRICT , NEW SOUTH WALES HEALTH PATHOLOGY
摘要： The present disclosure relates to compositions comprising isolated T cells, with activity against a fungal antigen, a viral antigen or a tumour antigen, wherein the composition comprises a defined number or defined ratio of T cells. Described herein are compositions comprising at least two populations of T cells, the compositions being suitable for treating various diseases and disorders.
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公开(公告)号：US20220152131A1
公开(公告)日：2022-05-19
申请号：US17404303
申请日：2021-08-17
摘要： The present invention relates to the treatment of bacterial infections and the reduction of inflammatory response using bacteriophage compositions. In an aspect, provided herein are methods of treating a bacterial infection characterized by inflammation in a subject, the method comprising administering to the subject a bacteriophage composition that is essentially free of impurities, wherein the composition reduces inflammation.
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公开(公告)号：US11039884B2
公开(公告)日：2021-06-22
申请号：US15580615
申请日：2016-06-10
发明人： Pierre Qian , Michael Anthony Barry
摘要： A microwave ablation device (10) comprises a feed line (22), a microwave radiator and a device outer sheath (46) in which at least part of the feed line (22) is contained. The sheath (46) in use, allows an irrigation liquid to flow therethrough, wherein the feed line has a junction (38) with the radiator (22) has an outer conducting shield (28) terminating and insulated at the junction (38). The feed line (22) has a conductive core (32) that extends to the radiator (24). The conductive core forms a radiating element (34) electrically insulated from its surrounding environment. The radiator (24) is unbalanced.
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公开(公告)号：US20200375658A1
公开(公告)日：2020-12-03
申请号：US16994134
申请日：2020-08-14
发明人： Pierre Qian , Michael Anthony Barry
摘要： The invention concerns a method for intra-operative monitoring of the effectiveness of transcatheter renal denervation in a patient, to assist in guiding the procedure and in particular for identifying a physiological procedural endpoint. Through aorticorenal ganglia pace-capture, renal sympathetic nerve function can be assessed. In accordance with the invention, sustained reduction or abolition of renal vasoconstriction induced by the pacing is used as an indicator of successful renal denervation.
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6.发明授权公开(公告)号：US10725026B2
公开(公告)日：2020-07-28
申请号：US15810861
申请日：2017-11-13
申请人： Icahn School of Medicine at Mount Sinai , Westmead Institute For Medical Research , Western Sydney Local Health District
摘要： A method for identifying a kidney transplant recipient at an increased risk of developing interstitial fibrosis or tubular atrophy which comprises obtaining a post-transplant urine sample from the kidney transplant recipient; measuring the level of clusterin in the urine sample; comparing the level of clusterin in the patient sample to the level of clusterin in a control sample from the urine of a non-fibrotic kidney transplant recipient; diagnosing a kidney transplant recipient with a clusterin level that is significantly higher than the clusterin level in the control as being at an increased risk of developing interstitial fibrosis or tubular atrophy.
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公开(公告)号：US10722178B2
公开(公告)日：2020-07-28
申请号：US15608666
申请日：2017-05-30
申请人： Western Sydney Local Health District , The University of Sydney , Katholieke Universiteit Leuven KU Leuven R&D
发明人： Roger Fulton , Johan Nuyts , Tao Sun , Jung-Ha Kim
IPC分类号： A61B6/00 , A61B5/00 , G06F3/0484
摘要： A method for the reduction of motion artifacts in CT imaging, the method including the steps of: (a) reconstructing from the raw CT data an initial estimate of the object of interest; (b) estimating the pose of the object at each projection angle; (c) undertaking a motion-corrected reconstruction from the measured projections, accounting for the pose changes estimated in (b) by employing a modified source/detector orbit that accounts for the object motion; (d) iterating steps (b)-(c) until a predetermined convergence criterion is met; and (e) making a final reconstruction of the required image size using the pose estimates obtained in the previous steps.
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公开(公告)号：US10709726B2
公开(公告)日：2020-07-14
申请号：US15751802
申请日：2016-08-12
发明人： Eddy Kizana , Peter Fahmy
IPC分类号： A61K31/7105 , A61K31/7088 , A61K31/713 , A61P9/10
摘要： The present disclosure generally relates to methods for treating, preventing, inhibiting the progression of or reducing the likelihood of occurrence of a myocardial infarction-related complication, a cardiac disorder characterised by abnormal conduction and other cardiac conditions. The present disclosure also generally relates to one or more inhibitors of Connexin 45.
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9.发明申请公开(公告)号：US20180292395A1
公开(公告)日：2018-10-11
申请号：US15810861
申请日：2017-11-13
申请人： Icahn School of Medicine at Mount Sinai , Westmead Institute For Medical Research , Western Sydney Local Health District
摘要： A method for identifying a kidney transplant recipient at an increased risk of developing interstitial fibrosis or tubular atrophy which comprises obtaining a post-transplant urine sample from the kidney transplant recipient; measuring the level of clusterin in the urine sample; comparing the level of clusterin in the patient sample to the level of clusterin in a control sample from the urine of a non-fibrotic kidney transplant recipient; diagnosing a kidney transplant recipient with a clusterin level that is significantly higher than the clusterin level in the control as being at an increased risk of developing interstitial fibrosis or tubular atrophy.
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公开(公告)号：US20240091270A1
公开(公告)日：2024-03-21
申请号：US18033760
申请日：2021-10-26
发明人： Kedar Ghimire , Natasha Rogers
IPC分类号： A61K35/39 , A61P3/10 , C07K16/28 , C12N5/071 , C12N15/113
CPC分类号： A61K35/39 , A61P3/10 , C07K16/2803 , C12N5/0676 , C12N15/1138 , A61K2039/505
摘要： The present invention generally relates to modulating insulin expression and production by targeting CD47. In a particular aspect, the invention relates increasing insulin expression by silencing or blocking CD47. In another aspect, the present invention relates to the delivery of insulin to a subject by pancreatic beta islet cells. Specifically, the present invention relates to the production of modified pancreatic beta islet cells that have increased insulin expression and production resulting from silencing or blocking CD47, which are suitable for beta cell transplantation, and methods of their production.
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