公开(公告)号：US20070184511A1

公开(公告)日：2007-08-09

申请号：US11561878

申请日：2006-11-20

申请人： Kevin Dawson ,  Wasyl Malyj ,  William Haddon ,  Daniel Tuse ,  Earl White ,  Driss Zoukhri ,  Ian Rawe

发明人： Kevin Dawson ,  Wasyl Malyj ,  William Haddon ,  Daniel Tuse ,  Earl White ,  Driss Zoukhri ,  Ian Rawe

IPC分类号： C12Q1/37 ,  G06F19/00

CPC分类号： G01N33/6848 ,  G16H10/20 ,  G16H50/70

摘要： Described is a method for diagnosing a person having or being at risk of developing Sjögren's Syndrome and excluding patients with symptoms similar to Sjögren's Syndrome but with a different etiology, comprising the following steps: providing a sample of a body fluid or tissue from said person, said sample containing a mixture of unknown proteins, protein fragments or peptides; analyzing said samples with mass spectrometry to generate a m/z (mass to charge ratio) spectrogram for each sample; comparing whether the patient's sample contains m/z values that are characteristic of a Sjögren's Syndrome reference database derived from the analysis and cataloguing of multiple patient spectrograms; and determining whether said patient either has or does not have Sjögren's Syndrome on the basis of this comparative analysis.

摘要翻译： 描述了一种用于诊断患有或有发展Sjögren综合征风险的人的方法，并排除具有与Sjögren综合征相似但具有不同病因的症状的患者，其包括以下步骤：从所述人提供体液或组织的样品， 所述样品含有未知蛋白质，蛋白质片段或肽的混合物; 通过质谱分析所述样品以产生每个样品的m / z（质荷比）谱图; 比较患者样本是否包含源自多个患者谱图分析和编目的Sjögren综合征参考数据库特征的m / z值; 并且基于该比较分析确定所述患者是否具有或不具有Sjögren综合征。

公开(公告)号：US20070249000A1

公开(公告)日：2007-10-25

申请号：US11740272

申请日：2007-04-25

申请人： Daniel Tuse ,  Kevin Dawson ,  William Haddon ,  Earl White ,  Wasyl Malyj

发明人： Daniel Tuse ,  Kevin Dawson ,  William Haddon ,  Earl White ,  Wasyl Malyj

IPC分类号： G01N33/574 ,  G01N33/50

CPC分类号： G01N33/57407

摘要： Described is a method for diagnosing a person having or being at risk of developing certain B-cell pathologies, including Sjögren's Syndrome and non-Hodgkin's lymphoma, and excluding patients with symptoms similar to Sjögren's Syndrome but with a different etiology, comprising the following steps: providing a sample of a body fluid or tissue from said person, said sample containing a mixture of unknown proteins, protein fragments or peptides; analyzing said samples with mass spectrometry to generate a m/z (mass to charge ratio) spectrogram for each sample; comparing whether the patient's sample contains m/z values that are characteristic of a Sjögren's Syndrome reference database derived from the analysis and cataloguing of multiple patient spectrograms; and determining whether said patient either has or does not have Sjögren's Syndrome on the basis of this comparative analysis.

摘要翻译： 描述了一种用于诊断具有或具有发展某些B细胞病变的风险的人的方法，包括Sjögren综合征和非霍奇金淋巴瘤，并且排除具有与Sjögren综合征相似但具有不同病因的患者，包括以下步骤： 提供来自所述人的体液或组织的样品，所述样品含有未知蛋白质，蛋白质片段或肽的混合物; 通过质谱分析所述样品以产生每个样品的m / z（质荷比）谱图; 比较患者样本是否包含源自多个患者谱图分析和编目的Sjögren综合征参考数据库特征的m / z值; 并且基于该比较分析确定所述患者是否具有或不具有Sjögren综合征。

公开(公告)号：US06601050B1

公开(公告)日：2003-07-29

申请号：US09625572

申请日：2000-07-25

申请人： Wasyl Malyj

发明人： Wasyl Malyj

IPC分类号： G06F1518

CPC分类号： G06K9/6232 ,  G06F19/22 ,  G06T9/008 ,  Y10S707/99933

摘要： Electronic data is classified using adaptive focused replicator networks (AFRNs). AFRNs are sets of array elements, each array element being trainable in order to replicate a predetermined sub-group of data. Unknown data is inputted into each and every array element in an AFRN array and then replicated by each element array. A comparison is made for each array element to determine the accuracy of each replication. If only one array element successfully replicates the unknown data, then the unknown data is classified in accordance with the corresponding predetermined sub-group of data.

摘要翻译： 使用自适应聚焦复制器网络（AFRN）对电子数据进行分类。 AFRN是阵列元素的集合，每个阵列元素是可训练的，以便复制预定的数据组。 未知数据被输入到AFRN阵列中的每个数组元素中，然后由每个元素数组复制。 对每个数组元素进行比较，以确定每个复制的准确性。 如果只有一个数组元素成功地复制未知数据，则根据对应的预定的数据组分类未知数据。