公开(公告)号：US20070184511A1

公开(公告)日：2007-08-09

申请号：US11561878

申请日：2006-11-20

申请人： Kevin Dawson ,  Wasyl Malyj ,  William Haddon ,  Daniel Tuse ,  Earl White ,  Driss Zoukhri ,  Ian Rawe

发明人： Kevin Dawson ,  Wasyl Malyj ,  William Haddon ,  Daniel Tuse ,  Earl White ,  Driss Zoukhri ,  Ian Rawe

IPC分类号： C12Q1/37 ,  G06F19/00

CPC分类号： G01N33/6848 ,  G16H10/20 ,  G16H50/70

摘要： Described is a method for diagnosing a person having or being at risk of developing Sjögren's Syndrome and excluding patients with symptoms similar to Sjögren's Syndrome but with a different etiology, comprising the following steps: providing a sample of a body fluid or tissue from said person, said sample containing a mixture of unknown proteins, protein fragments or peptides; analyzing said samples with mass spectrometry to generate a m/z (mass to charge ratio) spectrogram for each sample; comparing whether the patient's sample contains m/z values that are characteristic of a Sjögren's Syndrome reference database derived from the analysis and cataloguing of multiple patient spectrograms; and determining whether said patient either has or does not have Sjögren's Syndrome on the basis of this comparative analysis.

摘要翻译： 描述了一种用于诊断患有或有发展Sjögren综合征风险的人的方法，并排除具有与Sjögren综合征相似但具有不同病因的症状的患者，其包括以下步骤：从所述人提供体液或组织的样品， 所述样品含有未知蛋白质，蛋白质片段或肽的混合物; 通过质谱分析所述样品以产生每个样品的m / z（质荷比）谱图; 比较患者样本是否包含源自多个患者谱图分析和编目的Sjögren综合征参考数据库特征的m / z值; 并且基于该比较分析确定所述患者是否具有或不具有Sjögren综合征。