公开(公告)号：US20120189719A1

公开(公告)日：2012-07-26

申请号：US13298607

申请日：2011-11-17

申请人： WEN-LIANG CHANG ,  CHEN-WEN YAO ,  CHI-HONG CHU ,  AN-RONG LEE ,  ANN CHEN ,  WEN-HSIN HUANG ,  KUO-YUAN HWA ,  CHIAO-YING CHIEN ,  CHIEN-YI PAI

发明人： WEN-LIANG CHANG ,  CHEN-WEN YAO ,  CHI-HONG CHU ,  AN-RONG LEE ,  ANN CHEN ,  WEN-HSIN HUANG ,  KUO-YUAN HWA ,  CHIAO-YING CHIEN ,  CHIEN-YI PAI

IPC分类号： A61K36/00 ,  A61K31/343 ,  A61P31/16 ,  A61K31/122

CPC分类号： A61K36/79 ,  A61K31/122 ,  A61K31/357 ,  A61K2236/35

摘要： Disclosed are an Schisandrae fructus extract for inhibition or prevention of influenza and its application, wherein the Schisandrae fructus extract is obtained by water, methanol, or ethanol extraction process and the extract comprises compounds such as schisandrone, benzoylgomisin P, wulignan A1, epigomisin O, epiwulignan A1, and tigloylgomisin P. The extracts and purified compounds of Schisandrae fructus has anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities, therefore the extracts and the purified compounds of Schisandrae fructus can be applied as an inhitibory agent of a pharmaceutical composition for treatment or prevention agent for influenza infection.

摘要翻译： 公开了用于抑制或预防流感及其应用的五味子提取物，其中五味子提取物通过水，甲醇或乙醇提取方法获得，并且提取物包含化合物，例如五味子酮，苯甲酰基乳球菌素P，五味子胺A1，表不见素O， 五味子甙A和枸橼酸甘草聚糖P.提取物和纯化的五味子化合物具有抗流感病毒H1N1和H1N1-TR（达菲药物耐药病毒株）的活性，因此五味子的提取物和纯化的化合物可以作为 用于流感感染的治疗或预防剂的药物组合物的生物剂。

公开(公告)号：US20100165799A1

公开(公告)日：2010-07-01

申请号：US12344237

申请日：2008-12-25

申请人： Wen-Hsin HUANG

发明人： Wen-Hsin HUANG

IPC分类号： G04B9/00

CPC分类号： G04B5/00 ,  G04D7/009

摘要： A watch winder with a sensing switch comprises a housing, a driving member, a rotary watch mount, a light sensor, an adjustable counting device and a main board. The housing is divided by a mid clapboard into a display space and an assembly space. The drive member has a rotary shaft and is disposed in the assembly space, and the rotary shaft is inserted through the mid clapboard into the display space. The rotary watch mount has a fixing portion fixed to the rotary shaft of the drive member and a lightproof portion. The light sensor is disposed on the mid clapboard to sense the lightproof portion. The adjustable counting device is disposed on the mid clapboard and its value is manually adjustable. The main board is disposed in the assembly space of the housing and electrically connected with the drive member, the light sensor and the adjustable counting device.

摘要翻译： 具有感测开关的手表络纱机包括外壳，驱动构件，旋转表座，光传感器，可调计数装置和主板。 外壳由中间隔板分隔成显示空间和组装空间。 驱动构件具有旋转轴并且设置在组装空间中，并且旋转轴通过中间隔板插入到显示空间中。 旋转式手表安装座具有固定在驱动构件的旋转轴上的固定部分和防光部分。 光传感器设置在中间隔板上以感测防光部分。 可调计数装置设置在中间隔板上，其值可手动调节。 主板设置在壳体的组装空间中，与驱动构件，光传感器和可调计数装置电连接。

公开(公告)号：US06247424B1

公开(公告)日：2001-06-19

申请号：US09517553

申请日：2000-03-02

申请人： Wen-Hsin Huang

发明人： Wen-Hsin Huang

IPC分类号： E01F912

CPC分类号： E01F13/02 ,  E01F9/654 ,  E01F9/688

摘要： A traffic-control warning cone includes a hollow cone at bottom end of which a proper area extends outwards and is formed as flat bottom, then extending outwards and upwards with a certain height and formed as a circular border. A heavy body is mounted on the flat bottom so that the whole body won't be toppled and be kept in an upright state no matter how it is placed so that the present invention won't be toppled, ensures the warning effect and enhances the convenience in using.

摘要翻译： 交通控制警告锥包括底端的中空锥体，其适当的区域向外延伸并形成为平坦的底部，然后以一定的高度向外和向上延伸并形成为圆形边界。 将重体安装在平坦的底部，使得整个身体不会被翻倒，并且保持在直立状态，无论如何被放置，使得本发明不会被推倒，确保警告效果并增强 使用方便。

公开(公告)号：US06727272B1

公开(公告)日：2004-04-27

申请号：US10195824

申请日：2002-07-15

申请人： An-Rong Lee ,  Wen-Hsin Huang ,  Jiajiu Shaw

发明人： An-Rong Lee ,  Wen-Hsin Huang ,  Jiajiu Shaw

IPC分类号： A61K31422

CPC分类号： C07D261/18

摘要： Novel leflunomide analogs were synthesized and evaluated in-vivo. Based on the in-vivo studies, these analogs are surprisingly effective for treating rheumatoid arthritis.

摘要翻译： 新型的来氟米特类似物在体内合成和评价。 基于体内研究，这些类似物对于治疗类风湿性关节炎是惊人的。

公开(公告)号：US20150353515A1

公开(公告)日：2015-12-10

申请号：US14297806

申请日：2014-06-06

申请人： Wen-Hsin Huang ,  Chien-Ming Huang ,  An-Rong Lee ,  Jiajiu Shaw

发明人： Wen-Hsin Huang ,  Chien-Ming Huang ,  An-Rong Lee ,  Jiajiu Shaw

IPC分类号： C07D277/64

CPC分类号： C07D277/64

摘要： For the reported resveratrol analogs, the (E)-stilbene core structure is either maintained intact or only slightly modified. We use a different approach and introduced a novel heterocyclic benzothiazolium moiety into the (E)-stilbene core to form a series of novel resveratrol analogs for treating angiogenic- and/or inflammation-related disorders.

摘要翻译： 对于报道的白藜芦醇类似物，（E） - 二苯乙烯核心结构保持完整或仅稍微修改。 我们使用不同的方法，并将新的杂环苯并噻唑部分引入到（E） - 二烯烃核心中以形成一系列用于治疗血管生成和/或炎症相关疾病的新型白藜芦醇类似物。

公开(公告)号：US20120101157A1

公开(公告)日：2012-04-26

申请号：US13279519

申请日：2011-10-24

申请人： AN-RONG LEE ,  WEN-HSIN HUANG ,  CHI-HONG CHU ,  WEN-LIANG CHANG ,  CHEN-WEN YAO ,  I-LING CHEN

发明人： AN-RONG LEE ,  WEN-HSIN HUANG ,  CHI-HONG CHU ,  WEN-LIANG CHANG ,  CHEN-WEN YAO ,  I-LING CHEN

IPC分类号： A61K31/245 ,  C07C233/54 ,  C07C231/14 ,  A61P31/16 ,  C07C277/08 ,  C07C279/18 ,  A61K31/196

CPC分类号： C07C233/54 ,  C07C279/18

摘要： Disclosed are 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives and manufactures thereof. The 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives are presented by formula (I): wherein R1 group is H, CH3, or C2H5; R2 group is H, or Br; R3 group is CH3, or C3H7; and R4 group is H, or C(═NH)—NH2. 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives provided here were non-toxic to MDCK cells, particularly compounds 6a, 6b, 6c, 6e, 6f, 7a, 7b and 8 had better anti-H1N1 activity. In the future, these compounds can be used to focus on viral neuraminidases as targets to develop effective anti-influenza drugs.

摘要翻译： 公开了4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物及其制造方法。 4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物由式（I）表示：其中R 1基团是H，CH 3或C 2 H 5; R2组为H或Br; R3基团是CH3或C3H7; 和R 4基团是H或C（= NH）-NH 2。 本文提供的4,5-二氨基-3-卤代-2-羟基苯甲酸衍生物对MDCK细胞无毒，特别是化合物6a，6b，6c，6e，6f，7a，7b和8具有更好的抗H1N1活性。 未来，这些化合物可用于将病毒性神经氨酸酶作为靶点开发有效的抗流感药物。

公开(公告)号：US20110124721A1

公开(公告)日：2011-05-26

申请号：US13016769

申请日：2011-01-28

申请人： Jia-Yi WANG ,  Wen-Hsin HUANG ,  Szu-Fu CHEN

发明人： Jia-Yi WANG ,  Wen-Hsin HUANG ,  Szu-Fu CHEN

IPC分类号： A61K31/353 ,  A61P25/00 ,  A61P29/00

CPC分类号： A61K31/352

摘要： The invention provides a novel medical use of Baicalein, and in particular, a use of baicalein in the preparation of a pharmaceutical composition useful for treating traumatic brain injury. The baicalein pharmaceutical composition in this invention includes a treating effective amount of baicalein and a suitable pharmaceutically acceptable excipient or carrier. The baicalein pharmaceutical composition is applicable for improving the behaviour function deficit in traumatic brain injury, reducing the contusion volume of traumatic brain injury, improving the brain neuronal degeneration in traumatic brain injury, reducing proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) or other relative inflammation factor induced in traumatic brain injury.

摘要翻译： 本发明提供了一种新颖的医学用途的黄芩素，特别是黄芩素在制备用于治疗创伤性脑损伤的药物组合物中的应用。 本发明的黄芩素药物组合物包括治疗有效量的黄芩素和合适的药学上可接受的赋形剂或载体。 黄芩苷药物组合物适用于改善创伤性脑损伤的行为功能缺陷，减少创伤性脑损伤的挫伤量，改善创伤性脑损伤的脑神经元变性，减少促炎细胞因子如肿瘤坏死因子-α（TNF-α ），白介素-1和bgr （IL-1和bgr），白细胞介素-6（IL-6）或其他在创伤性脑损伤中诱导的相关炎症因子。

公开(公告)号：US07927009B2

公开(公告)日：2011-04-19

申请号：US12344517

申请日：2008-12-27

申请人： Wen-Hsin Huang

发明人： Wen-Hsin Huang

IPC分类号： G04B3/00

CPC分类号： G04D7/009 ,  G04B5/00

摘要： A watch winder comprising plural watch winder units and a power supply. The plural watch winder units are assembled by connectors in such a manner that the watch winders units are electrically connected to one another, and the power supply is electrically connected to one of the watch winder units to supply power to all the electrically-connected watch winder units. By such arrangements, the respective watch winder units are not required to be provided with one power supply, thus saving the manufacturing cost, satisfying the requirements of environmental protection, and the watch winder units can be assembled as desired.

摘要翻译： 一种手表络纱机，包括多个手表络纱机和电源。 多个手表络纱机由连接器组装，使得手表卷绕机单元彼此电连接，并且电源电连接到手表复卷机之一，以向所有电连接的手表络纱机 单位。 通过这样的布置，各个钟表卷取机单元不需要设置一个电源，从而节省了制造成本，满足环境保护的要求，并且可以根据需要组装表卷收单元。

公开(公告)号：US20100222421A1

公开(公告)日：2010-09-02

申请号：US12395287

申请日：2009-02-27

申请人： Jia-Yi WANG ,  Wen-Hsin HUANG ,  Szu-Fu CHEN

发明人： Jia-Yi WANG ,  Wen-Hsin HUANG ,  Szu-Fu CHEN

IPC分类号： A61K31/352 ,  A61P25/00

CPC分类号： A61K31/352

摘要： The invention provides a novel medical use of Baicalein, and in particular, a use of baicalein in the preparation of a pharmaceutical composition useful for treating traumatic brain injury. The baicalein pharmaceutical composition in this invention includes a treating effective amount of baicalein and a suitable pharmaceutically acceptable excipient or carrier. The baicalein pharmaceutical composition is applicable for improving the behaviour function deficit in traumatic brain injury, reducing the contusion volume of traumatic brain injury, improving the brain neuronal degeneration in traumatic brain injury, reducing proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) or other relative inflammation factor induced in traumatic brain injury.

摘要翻译： 本发明提供了一种新颖的医学用途的黄芩素，特别是黄芩素在制备用于治疗创伤性脑损伤的药物组合物中的应用。 本发明的黄芩素药物组合物包括治疗有效量的黄芩素和合适的药学上可接受的赋形剂或载体。 黄芩苷药物组合物适用于改善创伤性脑损伤的行为功能缺陷，减少创伤性脑损伤的挫伤量，改善创伤性脑损伤的脑神经元变性，减少促炎细胞因子如肿瘤坏死因子-α（TNF-α ），白介素-1和bgr （IL-1和bgr），白细胞介素-6（IL-6）或其他在创伤性脑损伤中诱导的相关炎症因子。

公开(公告)号：US20060223873A1

公开(公告)日：2006-10-05

申请号：US11093182

申请日：2005-03-29

申请人： Jiajiu Shaw ,  An-Rong Lee ,  Wen-Hsin Huang

发明人： Jiajiu Shaw ,  An-Rong Lee ,  Wen-Hsin Huang

IPC分类号： A61K31/42 ,  C07D413/02 ,  C07D261/18

CPC分类号： C07D261/18

摘要： A series of isoxazole derivatives and methods of suppressing, inhibiting, or preventing disorders mediated by nitric oxide (NO) and/or proinflammatory cytokines, such as TNF-α (tumor necrosis factor alpha), IL-1 (interlukin-1), and IL-6, are described.

摘要翻译： 一系列异恶唑衍生物和抑制，抑制或预防由一氧化氮（NO）和/或促炎细胞因子如TNF-α（肿瘤坏死因子α），IL-1（白介素-1）和 描述了IL-6。