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    Support structures for embolic filtering devices
    2.
    发明申请
    Support structures for embolic filtering devices 审中-公开
    栓塞过滤装置的支撑结构

    公开(公告)号：US20070167976A1

    公开(公告)日：2007-07-19

    申请号：US11698516

    申请日：2007-01-25

    申请人： William Boyle ,  John Papp ,  Francisco Sanchez ,  Steven Saville

    发明人： William Boyle ,  John Papp ,  Francisco Sanchez ,  Steven Saville

    IPC分类号： A61M29/00

    CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008 ,  A61M25/0014

    摘要： An inner support structure for an embolic filtering device includes a tubular member having a first support region for supporting the proximal portion of a filter assembly and a second support region for supporting the distal portion of the filter assembly. The inner support structure facilitates rotation and restricts longitudinal movement of the embolic filtering device relative to a guide wire. Alternatively, the inner support structure includes a bushing coupled to the guide wire and a sleeve with a head on its proximal end positioned within a cavity in the bushing, thereby facilitating rotation and restricting longitudinal movement of the sleeve. The proximal portion of the filter assembly is supported on the sleeve. A sleeve for retaining the struts of an expandable cage of the embolic filtering device includes a central lumen for positioning the sleeve onto a guide wire and peripheral lumens for positioning and retaining the struts.

    摘要翻译： 用于栓塞过滤装置的内部支撑结构包括管状构件，其具有用于支撑过滤器组件的近侧部分的第一支撑区域和用于支撑过滤器组件的远端部分的第二支撑区域。 内部支撑结构有助于旋转并且限制栓塞过滤装置相对于导丝的纵向移动。 或者，内部支撑结构包括联接到导丝的衬套和套筒，其顶端位于其近端位于套管内的空腔内，从而有助于旋转并限制套筒的纵向移动。 过滤器组件的近端部分被支撑在套筒上。 用于保持栓塞过滤装置的可膨胀笼的支柱的套筒包括用于将套管定位在导丝和用于定位和保持支柱的外围腔的中央腔。

    EXPANDABLE CAGES FOR EMBOLIC FILTERING DEVICES
    4.
    发明申请
    EXPANDABLE CAGES FOR EMBOLIC FILTERING DEVICES 审中-公开
    用于嵌入式过滤装置的可扩展的纸张

    公开(公告)号：US20080091231A1

    公开(公告)日：2008-04-17

    申请号：US11956990

    申请日：2007-12-14

    申请人： William Boyle ,  William Harrison ,  Benjamin Huter ,  Scott Huter ,  Paul Muller ,  John Papp

    发明人： William Boyle ,  William Harrison ,  Benjamin Huter ,  Scott Huter ,  Paul Muller ,  John Papp

    IPC分类号： A61M29/00

    CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/008

    摘要： A self-expanding cage for use in conjunction with an embolic filtering device includes a circumferential member adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. A proximal strut and distal strut are attached to the circumferential member to form the cage. A plurality of proximal and distal struts may be attached the circumferential member. Additionally, a second circumferential member can be attached to the first circumferential member. Each circumferential member can be connected by a single or a plurality of connecting struts. One embodiment of the cage utilizes a single wire to form to the cage. A delivery system attached to the single wire cage moves the cage and its associated filter element between the expanded and unexpanded positions through relative movement of the distal delivery system. This can be accomplished by either torquing the guide wire onto which the expandable cage is mounted or by longitudinally moving a tubular member which forms part of the delivery system longitudinally in relation to the guide wire.

    摘要翻译： 用于与栓塞过滤装置结合使用的自膨胀笼包括适于从未膨胀位置膨胀到患者体内容器内的扩张位置的周向构件。 近端支柱和远侧支柱附接到周向构件以形成保持架。 多个近端和远侧支柱可以附接在周向构件上。 此外，第二周向构件可以附接到第一圆周构件。 每个周向构件可以通过单个或多个连接支柱连接。 笼的一个实施例使用单个线来形成笼。 附接到单线笼的输送系统通过远端输送系统的相对运动使笼及其相关联的过滤元件在膨胀位置和未膨胀位置之间移动。 这可以通过扭转其上安装有可膨胀笼的引导线或通过纵向移动相对于导丝纵向移动形成输送系统的一部分的管状构件来实现。

    Embolic protection devices
    5.
    发明申请
    Embolic protection devices 有权
    栓塞保护装置

    公开(公告)号：US20070167975A1

    公开(公告)日：2007-07-19

    申请号：US11651667

    申请日：2007-01-10

    申请人： William Boyle ,  David Burkett ,  Andy Denison ,  Benjamin Huter ,  Scott Huter ,  Arkady Kokish ,  Kent Stalker ,  Chicheng Wang ,  John Whitfield

    发明人： William Boyle ,  David Burkett ,  Andy Denison ,  Benjamin Huter ,  Scott Huter ,  Arkady Kokish ,  Kent Stalker ,  Chicheng Wang ,  John Whitfield

    IPC分类号： A61M29/00

    CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

    摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

    摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好被医师部署为止。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

    Embolic filtering devices for bifurcated vessels
    7.
    发明申请
    Embolic filtering devices for bifurcated vessels 有权

    公开(公告)号：US20050182441A1

    公开(公告)日：2005-08-18

    申请号：US11108309

    申请日：2005-04-18

    申请人： Andy Denison ,  William Boyle

    发明人： Andy Denison ,  William Boyle

    IPC分类号： A61F2/01 ,  A61F2/06 ,  A61M29/00

    CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2002/065 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/008

    摘要： An embolic filtering device for use in a bifurcated vessel includes delivery device having a first guide wire and a second guide wire. The second guide wire diverges from the distal-end region of the first guide wire. The filter device also includes a filter support having a first deployment member and a second deployment member. These deployment members can be formed as a first loop and a second loop. A bifurcated filter element is coupled to the filter support. The distal-end region of the first guide wire extends through a first leg of the filter element and the second guide wire extends through a second leg of the filter element. During use, the first leg of the filter element is deployed within a first branch of the bifurcated vessel and the second leg of the filter element is deployed within a second branch of the bifurcated vessel.

    Osteoprotegerin binding proteins
    9.
    发明申请
    Osteoprotegerin binding proteins 有权
    骨保护蛋白结合蛋白

    公开(公告)号：US20060246064A1

    公开(公告)日：2006-11-02

    申请号：US11336067

    申请日：2006-01-19

    申请人： William Boyle

    发明人： William Boyle

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/70575 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70578 ,  C07K2319/30

    摘要： A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided.

    摘要翻译： 已经基于其对骨保护素的亲和力，鉴定了参与骨转播成熟的新型多肽，骨保护蛋白结合蛋白。 还描述了编码多肽或其片段，类似物或衍生物的核酸序列，用于产生的载体和宿主细胞，制备骨保护蛋白结合蛋白的方法和结合测定。 还提供了用于治疗骨质疏松症，由于关节炎或转移引起的骨丢失，高钙血症和佩吉特氏病等骨疾病的组合物和方法。

    Combination therapy for conditions leading to bone loss
    10.
    发明申请
    Combination therapy for conditions leading to bone loss 审中-公开
    组合治疗导致骨质流失的病症

    公开(公告)号：US20050147611A1

    公开(公告)日：2005-07-07

    申请号：US11058073

    申请日：2005-02-14

    申请人： William Boyle ,  David Lacey ,  Frank Calzone ,  Ming-Shi Chang ,  Giorgio Senaldi

    发明人： William Boyle ,  David Lacey ,  Frank Calzone ,  Ming-Shi Chang ,  Giorgio Senaldi

    IPC分类号： A61K38/00 ,  A61K38/17 ,  A61K38/55 ,  A61K48/00 ,  C07K14/705 ,  A61K39/395

    CPC分类号： C07K14/70578 ,  A01K2217/05 ,  A61K38/00 ,  A61K38/1793 ,  A61K48/00 ,  C07K2319/00 ,  A61K2300/00

    摘要： The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis. Methods of treatment are described using the polypeptides in conjunction with various agents, including IL-1 inhibitors, TNF-α inhibitors, and serine protease inhibitors.

    摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合OPG的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。 使用多种结合多种试剂（包括IL-1抑制剂，TNF-α抑制剂和丝氨酸蛋白酶抑制剂）描述治疗方法。