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公开(公告)号：US20110280922A1
公开(公告)日：2011-11-17
申请号：US13063887
申请日：2009-11-09
申请人： Eyal S. Ron , William F. Crowley , Robert Langer , Surajit K. Biswas , Quentin Baca , Armen Tashjian , Preston H. Saunders
发明人： Eyal S. Ron , William F. Crowley , Robert Langer , Surajit K. Biswas , Quentin Baca , Armen Tashjian , Preston H. Saunders
IPC分类号： A61F13/20 , A61K38/02 , A61P31/12 , A61K47/32 , A61K47/34 , A61M31/00 , A61K31/56 , A61K38/09
CPC分类号： A61K47/32 , A61F13/20 , A61K9/0036 , A61K9/0092 , A61K38/09 , A61M31/002
摘要： The invention relates to a therapeutic device for the delivery of therapeutic agents, e.g. a peptide such as leuprolide, via the vagina to a female mammal. In some embodiments, the invention also relates to methods for the treatment of obesity and eating disorders, diabetes, multiple sclerosis (MS), endometriosis, uterine fibroids, polycystic ovarian disease, various cancers such as breast cancer, acne, hirsutism, microbial or fungal or viral infections such as bacterial vaginosis or AIDS/HIV, and chronic diseases using a disclosed vaginal device.
摘要翻译： 本发明涉及用于递送治疗剂的治疗装置，例如， 一种肽，如亮丙瑞林，通过阴道到雌性哺乳动物。 在一些实施方案中，本发明还涉及治疗肥胖症和进食障碍，糖尿病，多发性硬化（MS），子宫内膜异位症，子宫肌瘤，多囊卵巢疾病，各种癌症如乳腺癌，痤疮，多毛症，微生物或真菌的方法 或病毒感染如细菌性阴道炎或AIDS / HIV，以及使用公开的阴道装置的慢性疾病。
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公开(公告)号：US20080248017A1
公开(公告)日：2008-10-09
申请号：US12125571
申请日：2008-05-22
IPC分类号： A61K38/43 , A61K47/30 , A61K47/32 , A61K38/45 , A61K31/715 , A61K39/00 , A61K38/18 , A61K39/395 , A61K38/46 , A61K38/44 , A61K31/56
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
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公开(公告)号：US07833545B2
公开(公告)日：2010-11-16
申请号：US10835414
申请日：2004-04-29
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
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公开(公告)号：US20090060982A1
公开(公告)日：2009-03-05
申请号：US12125629
申请日：2008-05-22
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
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公开(公告)号：US07838024B2
公开(公告)日：2010-11-23
申请号：US12125571
申请日：2008-05-22
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
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公开(公告)号：US20090274654A1
公开(公告)日：2009-11-05
申请号：US12125581
申请日：2008-05-22
IPC分类号： A61K38/21 , A61K38/09 , A61K31/566
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译： 本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。 药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。 本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。
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公开(公告)号：US20080286339A1
公开(公告)日：2008-11-20
申请号：US12125606
申请日：2008-05-22
IPC分类号： A61F6/14 , A61K31/565
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译： 本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。 药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。 本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。
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8.发明授权
公开(公告)号：US4762717A
公开(公告)日：1988-08-09
申请号：US842643
申请日：1986-03-21
CPC分类号： A61K38/09 , Y10S514/80 , Y10S514/843 , Y10S930/13
摘要： This invention is directed to a delivery system and a method useful for preventing pregnancy in female mammals by administering an LHRH composition. The method comprises administering during the entire follicular phase of the menstrual cycle, beginning at the time of menses, an LHRH composition and sufficient levels of an estrogenic steroid to counteract the possibility of side effects which may develop during prolonged therepy with LHRH. Following the follicular phase, at the beginning of the luteal phase, and for the entire course of the luteal phase, the LHRH/estrogenic steroid combination administered during the follicular phase, in combination with a physiological amount of progestational steroid, is administered.The delivery system comprises means for administering the LHRH composition, estrogenic steroid and progestational steroid.
摘要翻译： 本发明涉及一种用于通过施用LHRH组合物来预防雌性哺乳动物怀孕的递送系统和方法。 该方法包括在月经周期开始的月经周期的整个滤泡阶段期间施用LHRH组合物和足够水平的雌激素类固醇以抵消在LHRH延长期间可能发生的副作用的可能性。 在黄体期后，在黄体期开始时，黄体期的整个过程中，施用在卵泡期施用的LHRH /雌激素类固醇组合，与生理量的孕激素类固醇组合。 递送系统包括用于施用LHRH组合物，雌激素类固醇和促孕甾体的装置。
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公开(公告)号：US20120202742A1
公开(公告)日：2012-08-09
申请号：US13007222
申请日：2011-01-14
IPC分类号： A61K31/57 , A61P15/18 , A61P5/24 , A61K31/565 , A61K38/09
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译： 本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。 药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。 本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。
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公开(公告)号：US07829112B2
公开(公告)日：2010-11-09
申请号：US12125593
申请日：2008-05-22
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
摘要翻译： 本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。 药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。 本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。
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