公开(公告)号：US06796168B1

公开(公告)日：2004-09-28

申请号：US10245237

申请日：2002-09-17

申请人： Larry J. Goldstein ,  William N. Hogenauer

发明人： Larry J. Goldstein ,  William N. Hogenauer

IPC分类号： G01N1100

CPC分类号： A61B5/02035 ,  G01N5/00 ,  G01N11/04 ,  G01N11/06

摘要： A method for determining the viscosity of a fluid flowing through a system at any point in the system whereby the method involves determining a characteristic relationship for the fluid between viscosity and shear rate; obtaining a shear rate of the fluid as it moves through at least one position in the system; and determining the viscosity of fluid at the at least one position by applying the shear rate to the characteristic relationship. Where the system is the circulatory system of a living being, the method includes determining a viscosity-shear rate relationship unique to that individual. Furthermore, the method further entails determining the actual viscosities and shear rates being experienced in selected blood vessels of the living being.

摘要翻译： 一种用于确定在系统中任何点流过系统的流体的粘度的方法，由此该方法包括确定粘度和剪切速率之间的流体的特性关系; 当流体通过系统中的至少一个位置时获得流体的剪切速率; 以及通过将剪切速率应用于所述特征关系来确定所述至少一个位置处的流体的粘度。 在系统是活体的循环系统的情况下，该方法包括确定该个体特有的粘度 - 剪切速率关系。 此外，该方法还需要确定在生物体的选定血管中经历的实际粘度和剪切速率。

公开(公告)号：US06484566B1

公开(公告)日：2002-11-26

申请号：US09722954

申请日：2000-11-27

申请人： Seyhun Shin ,  Young Cho ,  Kenneth Kensey ,  William N. Hogenauer

发明人： Seyhun Shin ,  Young Cho ,  Kenneth Kensey ,  William N. Hogenauer

IPC分类号： G01N1143

CPC分类号： A61B5/02035 ,  G01N11/04

摘要： A scanning rheometer is presented for the rheological property measurement of electrorheological (ER) and magnetorheological (MR) fluids using a non-linear viscoplastic model, based on the fluid height variation with respect to time. The rheometer basically includes a static (e.g., an overhead reservoir) or a dynamic source of fluid, a channel or slit whose sides form electrodes which are in contact with the flowing ER fluid, or a capillary tube exposed to a static/alternating magnetic field for flowing MR fluids, a transfer tube, either one or two riser tubes, and a column level detector for monitoring the column of fluid as it moves in one of the riser tubes. The column level detector is coupled to a processor which analyzes, among other things, column height vs. time data to determine both viscosity and yield stress. The rheometer overcomes one of the major drawbacks of the conventional rheometer: the inability to produce the yield stress of the ER, or MR, fluid in an absolute zero shear rate range. The results with this rheometer are compared with those obtained from a commercially-available rheometer which indicates excellent agreement.

摘要翻译： 基于相对于时间的流体高度变化，使用非线性粘弹性模型提供扫描流变仪用于电流变（ER）和磁流变（MR）流体的流变性质测量。 流变仪基本上包括静态（例如，顶部储存器）或动态流体源，其侧面形成与流动的ER流体接触的电极的通道或狭缝，或暴露于静态/交变磁场的毛细管 用于流动MR流体，传输管，一个或两个提升管，以及用于在流体管中的一个提升管中移动时监测流体柱的柱液位检测器。 柱级检测器耦合到处理器，其特别地分析柱高度与时间数据以确定粘度和屈服应力两者。 流变仪克服了常规流变仪的主要缺点之一：不能在绝对零剪切速率范围内产生ER或MR流体的屈服应力。 将该流变仪的结果与从市售的流变仪获得的结果进行比较，这表明出色的一致性。

公开(公告)号：US06322524B1

公开(公告)日：2001-11-27

申请号：US09439795

申请日：1999-11-12

申请人： Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim

发明人： Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim

IPC分类号： A61B500

CPC分类号： A61B5/6866 ,  A61B5/02035 ,  A61B5/15003 ,  A61B5/150992 ,  A61B5/155 ,  G01N11/04 ,  G01N11/06

摘要： A blood viscosity measuring system and methods for measuring blood viscosity system monitors the change in height of two, oppositely-moving, columns of blood from the circulating blood of a patient and, given the dimensions of a capillary tube through which the blood flows, determines the blood viscosity over a range of shears, especially low shears. The system includes a tube set (disposable or nonisposable) that includes a pair of riser tubes, a capillary tube of predetermined dimensions that is coupled between the riser tubes (or that forms a portion of one riser tube) and a valve mechanism for controlling the circulating flow of blood from the patient into the riser tubes. Respective sensors monitor the movement of the columns of blood in each of the riser tubes and an associated microprocessor analyzes these movements, along with the predetermined dimensions of the capillary tube to determine the viscosity of the patient's circulating blood.

摘要翻译： 一种血液粘度测量系统和用于测量血液粘度系统的方法监测来自患者的循环血液的两个相对运动的血液柱的高度变化，并且考虑到血液流过的毛细管的尺寸，确定 剪切范围内的血液粘度，特别是低剪切。 该系统包括管组（一次性或非一次性），其包括一对提升管，预定尺寸的毛细管连接在提升管之间（或形成一个提升管的一部分）和用于控制 将血液从患者循环到提升管中。 相应的传感器监测每个提升管中的血液柱的运动，并且相关微处理器分析这些运动以及毛细管的预定尺寸以确定患者循环血液的粘度。

公开(公告)号：US06907772B2

公开(公告)日：2005-06-21

申请号：US10831255

申请日：2004-04-23

申请人： Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim ,  Young Cho

发明人： Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim ,  Young Cho

IPC分类号： G01N33/483 ,  A61B5/145 ,  A61B5/15 ,  A61B10/00 ,  G01N11/00 ,  G01N11/04 ,  G01N11/06 ,  G01N33/15 ,  G01N33/487 ,  G01N33/49

CPC分类号： A61B5/6866 ,  A61B5/02035 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150786 ,  A61B5/150854 ,  A61B5/150992 ,  A61B5/154 ,  A61B5/155 ,  A61B5/157 ,  G01N11/04 ,  G01N11/06

摘要： A blood viscosity measuring system and methods for measuring blood viscosity monitors the change in height of one of two, oppositely-moving, columns of blood from the circulating blood of a patient and, given the dimensions of a capillary tube through which the blood flows and by detecting a single blood position of the other oppositely-moving column, determines the blood viscosity over a range of shears, especially low shears. The system includes a tube set (disposable or non-disposable) that includes a pair of riser tubes, a capillary tube of predetermined dimensions that is coupled between the riser tubes (or that forms a portion of one riser tube) and a valve mechanism for controlling the circulating flow of blood from the patient into the riser tubes. A sensor monitors the movement of one of the columns of blood in one of the riser tubes and a single point detector detects a single blood position of the other column of blood and an associated microprocessor analyzes this movement and single point, along with the predetermined dimensions of the capillary tube, to determine the viscosity of the patient's circulating blood.

摘要翻译： 血液粘度测量系统和测量血液粘度的方法监测来自患者的循环血液的两个相对移动的血液柱之一的高度变化，以及血液流过的毛细管的尺寸，以及 通过检测另一个相反移动柱的单个血液位置，确定剪切范围内的血液粘度，特别是低剪切。 该系统包括管组（一次性或非一次性），其包括一对提升管，预定尺寸的毛细管连接在提升管之间（或形成一个提升管的一部分）和用于 控制来自患者的血液循环流入提升管。 传感器监测其中一个提升管中的一列血液的运动，并且单点检测器检测另一列血液的单个血液位置，并且相关联的微处理器分析该运动和单个点以及预定的尺寸 的毛细管，以确定患者循环血液的粘度。

公开(公告)号：US06428488B1

公开(公告)日：2002-08-06

申请号：US09615340

申请日：2000-07-12

申请人： Kenneth Kensey ,  William N. Hogenauer ,  John E. Nash ,  Harold E. Clupper ,  Sangho Kim ,  Young Cho ,  Peter Randolph Hazard Stark ,  Robert O. Pellizzari ,  Sergey Kruss

发明人： Kenneth Kensey ,  William N. Hogenauer ,  John E. Nash ,  Harold E. Clupper ,  Sangho Kim ,  Young Cho ,  Peter Randolph Hazard Stark ,  Robert O. Pellizzari ,  Sergey Kruss

IPC分类号： A61B500

CPC分类号： A61B5/6866 ,  A61B5/02035 ,  A61B5/15003 ,  A61B5/150992 ,  G01N11/04 ,  G01N11/06

摘要： An apparatus and method for measuring the viscosity of Newtonian and non-Newtonian fluids over a range of shear rates, especially low shear rates, by monitoring two rising columns of fluid (Newtonian or non-Newtonian) that pass through respective capillaries having different lengths. Furthermore, a specialized column monitor is provided that uses multiple interrogation sources (e.g., lasers) and a single detector (e.g., a charge-coupled device (CCD) array) to continuously monitor both columns of fluid substantially simultaneously. In particular, the system includes a Y-connector to form two flow paths and wherein each flow path includes a tube that includes a riser tube, a capillary tube of predetermined dimensions and a valve in each for controlling the fluid flow in each path. The specialized column monitor monitors the movement of the fluid columns in each of the riser tubes and an associated microprocessor analyzes these movements, along with the predetermined dimensions of the capillary tubes and riser tubes to determine the viscosity of the fluid.

摘要翻译： 一种用于通过监测通过具有不同长度的相应毛细管的两个上升流体（牛顿或非牛顿）来测量牛顿和非牛顿流体在一定范围的剪切速率，特别是低剪切速率下的粘度的装置和方法。 此外，提供了使用多个询问源（例如，激光器）和单个检测器（例如，电荷耦合器件（CCD）阵列）的基本上同时连续监测流体两列的专门的列监视器。 特别地，该系统包括Y形连接器以形成两个流动路径，并且其中每个流动路径包括管，该管包括提升管，预定尺寸的毛细管和每个用于控制每个路径中的流体流的阀。 专门的列监视器监测每个提升管中的流体柱的运动，并且相关联的微处理器分析这些运动以及毛细管和提升管的预定尺寸以确定流体的粘度。

公开(公告)号：US06624435B2

公开(公告)日：2003-09-23

申请号：US10033841

申请日：2001-12-27

申请人： Kenneth Kensey ,  William N. Hogenauer ,  John E. Nash ,  Harold E. Clupper ,  Sangho Kim ,  Young Cho ,  Peter Randolph Hazard Stark ,  Roberto O. Pellizzari ,  Sergey Kruss

发明人： Kenneth Kensey ,  William N. Hogenauer ,  John E. Nash ,  Harold E. Clupper ,  Sangho Kim ,  Young Cho ,  Peter Randolph Hazard Stark ,  Roberto O. Pellizzari ,  Sergey Kruss

IPC分类号： G01N1506

CPC分类号： A61B5/6866 ,  A61B5/02035 ,  A61B5/15003 ,  A61B5/150992 ,  G01N11/04 ,  G01N11/06

摘要： An apparatus and method for measuring the viscosity of Newtonian and non-Newtonian fluids over a range of shear rates, especially low shear rates, by monitoring two rising columns of fluid (Newtonian or non-Newtonian) that pass through respective capillaries having different lengths. Furthermore, a specialized column monitor is provided that uses multiple interrogation sources (e.g., lasers) and a single detector (e.g., a charge-coupled device (CCD) array) to continuously monitor both columns of fluid substantially simultaneously. In particular, the system includes a Y-connector to form two flow paths and wherein each flow path includes a tube that includes a riser tube, a capillary tube of predetermined dimensions and a valve in each for controlling the fluid flow in each path. The specialized column monitor monitors the movement of the fluid columns in each of the riser tubes and an associated microprocessor analyzes these movements, along with the predetermined dimensions of the capillary tubes and riser tubes to determine the viscosity of the fluid.

公开(公告)号：US06564618B2

公开(公告)日：2003-05-20

申请号：US10196936

申请日：2002-07-17

申请人： Sehyun Shin ,  Young Cho ,  Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim

发明人： Sehyun Shin ,  Young Cho ,  Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim

IPC分类号： G01N1104

CPC分类号： A61B5/02035 ,  G01N11/04

摘要： A scanning rheometer is presented for the Theological property measurement of electrorheological (ER) and magnetorheological (MR) fluids using a non-linear viscoplastic model, based on the fluid height variation with respect to time. The rheometer basically includes a static (e.g., an overhead reservoir) or a dynamic source of fluid, a channel or slit whose sides form electrodes which are in contact with the flowing ER fluid, or a capillary tube exposed to a static/alternating magnetic field for flowing MR fluids, a transfer tube, either one or two riser tubes, and a column level detector for monitoring the column of fluid as it moves in one of the riser tubes. The column level detector is coupled to a processor which analyzes, among other things, column height vs. time data to determine both viscosity and yield stress. The rheometer overcomes one of the major drawbacks of the conventional rheometer: the inability to produce the yield stress of the ER, or MR, fluid in an absolute zero shear rate range. The results with this rheometer are compared with those obtained from a commercially-available rheometer which indicates excellent agreement.

摘要翻译： 基于相对于时间的流体高度变化，使用非线性粘弹性模型提供扫描流变仪用于电流变学（ER）和磁流变（MR）流体的神经性质测量。 流变仪基本上包括静态（例如，顶部储存器）或动态流体源，其侧面形成与流动的ER流体接触的电极的通道或狭缝，或暴露于静态/交变磁场的毛细管 用于流动MR流体，传输管，一个或两个提升管，以及用于在流体管中的一个提升管中移动时监测流体柱的柱液位检测器。 柱级检测器耦合到处理器，其特别地分析柱高度与时间数据以确定粘度和屈服应力两者。 流变仪克服了常规流变仪的主要缺点之一：不能在绝对零剪切速率范围内产生ER或MR流体的屈服应力。 将该流变仪的结果与从市售的流变仪获得的结果进行比较，这表明出色的一致性。

公开(公告)号：US06402703B1

公开(公告)日：2002-06-11

申请号：US09573267

申请日：2000-05-18

申请人： Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim ,  Young Cho

发明人： Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim ,  Young Cho

IPC分类号： A61B500

CPC分类号： A61B5/6866 ,  A61B5/02035 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150786 ,  A61B5/150854 ,  A61B5/150992 ,  A61B5/154 ,  A61B5/155 ,  A61B5/157 ,  G01N11/04 ,  G01N11/06

摘要： A blood viscosity measuring system and methods for measuring blood viscosity monitors the change in height of one of two, oppositely-moving, columns of blood from the circulating blood of a patient and, given the dimensions of a capillary tube through which the blood flows and by detecting a single blood position of the other oppositely-moving column, determines the blood viscosity over a range of shears, especially low shears. The system includes a tube set (disposable or non-disposable) that includes a pair of riser tubes, a capillary tube of predetermined dimensions that is coupled between the riser tubes (or that forms a portion of one riser tube) and a valve mechanism for controlling the circulating flow of blood from the patient into the riser tubes. A sensor monitors the movement of one of the columns of blood in one of the riser tubes and a single point detector detects a single blood position of the other column of blood and an associated microprocessor analyzes this movement and single point, along with the predetermined dimensions of the capillary tube, to determine the viscosity of the patient's circulating blood.

摘要翻译： 血液粘度测量系统和测量血液粘度的方法监测来自患者的循环血液的两个相对移动的血液柱之一的高度变化，以及血液流过的毛细管的尺寸，以及 通过检测另一个相反移动柱的单个血液位置，确定剪切范围内的血液粘度，特别是低剪切。 该系统包括管组（一次性或非一次性），其包括一对提升管，预定尺寸的毛细管连接在提升管之间（或形成一个提升管的一部分）和用于 控制来自患者的血液循环流入提升管。 传感器监测其中一个提升管中的一列血液的运动，并且单点检测器检测另一列血液的单个血液位置，并且相关联的微处理器分析该运动和单个点以及预定的尺寸 的毛细管，以确定患者循环血液的粘度。

公开(公告)号：US06745615B2

公开(公告)日：2004-06-08

申请号：US09973639

申请日：2001-10-09

申请人： Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim ,  Young Cho

发明人： Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim ,  Young Cho

IPC分类号： G01N1104

CPC分类号： A61B5/6866 ,  A61B5/02035 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150786 ,  A61B5/150854 ,  A61B5/150992 ,  A61B5/154 ,  A61B5/155 ,  A61B5/157 ,  G01N11/04 ,  G01N11/06

摘要： A blood viscosity measuring system and methods for measuring blood viscosity monitors the change in height of one of two, oppositely-moving, columns of blood from the circulating blood of a patient and, given the dimensions of a capillary tube through which the blood flows and by detecting a single blood position of the other oppositely-moving column, determines the blood viscosity over a range of shears, especially low shears. The system includes a tube set (disposable or non-disposable) that includes a pair of riser tubes, a capillary tube of predetermined dimensions that is coupled between the riser tubes (or that forms a portion of one riser tube) and a valve mechanism for controlling the circulating flow of blood from the patient into the riser tubes. A sensor monitors the movement of one of the columns of blood in one of the riser tubes and a single point detector detects a single blood position of the other column of blood and an associated microprocessor analyzes this movement and single point, along with the predetermined dimensions of the capillary tube, to determine the viscosity of the patient's circulating blood.

公开(公告)号：US06571608B2

公开(公告)日：2003-06-03

申请号：US10156165

申请日：2002-05-28

申请人： Sehyun Shin ,  Young Cho ,  Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim

发明人： Sehyun Shin ,  Young Cho ,  Kenneth Kensey ,  William N. Hogenauer ,  Sangho Kim

IPC分类号： G01N1100

CPC分类号： A61B5/02035 ,  G01N5/00 ,  G01N11/04 ,  G01N11/06

摘要： An apparatus and method for determining the viscosity of a fluid over plural shear rates caused by a decreasing pressure differential by monitoring the movement of the fluid through a riser tube and a capillary tube. The movement can be monitored by detecting the changing weight of the fluid, using a precision balance or load cell, as it moves through the riser tube and capillary tube into a fluid collector; or, alternatively, the movement can be monitored by detecting the changing level of a fluid column in the riser tube using a column level detector. A processor then uses the changing weight or height data, along with the dimensions of the capillary tube and a dimension of the riser tube, to determine the viscosity of the fluid. In addition, apparatus and methods for determining fluid viscosity online and fluid mixture homogeneity online are also described.