公开(公告)号：US20100160747A1

公开(公告)日：2010-06-24

申请号：US12636771

申请日：2009-12-13

申请人： Mark Ries Robinson ,  Andrea Magee ,  Michael J. Haass ,  Russell E. Abbink ,  William Radigan ,  V. Gerald Grafe

发明人： Mark Ries Robinson ,  Andrea Magee ,  Michael J. Haass ,  Russell E. Abbink ,  William Radigan ,  V. Gerald Grafe

IPC分类号： A61B5/1468 ,  A61B5/00

CPC分类号： A61B5/061 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/442 ,  A61B5/444

摘要： The present invention relates to measurements of material properties by determination of the response of a sample to incident radiation, and more specifically to the measurement of analytes such as glucose or alcohol in human tissue. The invention is particularly useful in connection with noncontact optical sampling of skin. Some example embodiments of the invention provide for selection of preferred sampling locations responsive to optically-determined characteristics of the tissue. Some example embodiments of the invention provide for precise and repeatable alignment of the tissue based on optically-determined characteristics of the tissue.

摘要翻译： 本发明涉及通过测定样品对入射辐射的响应，更具体地涉及人体组织中分析物如葡萄糖或酒精的测量来测量材料性质。 本发明特别适用于皮肤的非接触光学取样。 本发明的一些示例性实施例提供了响应于光学确定的组织特征的优选采样位置的选择。 本发明的一些示例性实施例提供了基于光学确定的组织特征的组织的精确和可重复的对准。

公开(公告)号：US20100113899A1

公开(公告)日：2010-05-06

申请号：US12614056

申请日：2009-11-06

申请人： Mark Ries Robinson ,  Andrea Magee ,  Michael U. Haass ,  Russell E. Abbink ,  William Radigan ,  V. Gerald Grafe

发明人： Mark Ries Robinson ,  Andrea Magee ,  Michael U. Haass ,  Russell E. Abbink ,  William Radigan ,  V. Gerald Grafe

IPC分类号： A61B5/1455

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6825 ,  A61B5/6826 ,  A61B5/6838

摘要： This invention relates to measurements of material properties by determination of the response of a sample to incident radiation, and more specifically to the measurement of analytes such as glucose or alcohol in human tissue. Some example embodiments of the present invention provide an optical sampling apparatus including an optical subsystem, having a receiver for receiving light expressed from tissue; and an alignment subsystem, adapted to urge a portion of a hand placed in operative relationship with the alignment subsystem into a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a substrate having a plurality of projections therefrom disposed in a pattern such that the projections urge a portion of a hand placed on the substrate to a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a substrate having a surface defining a volume approximating the shape of a portion of a hand such that the volume urges a portion of a hand placed therein to a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a surface having a generally U-shaped cross-section and extending for a distance, wherein the surface is mounted relative to the sampling means such that a finger placed in the U-shaped cross-section of the surface is urged to a defined configuration relative to the receiver. In some such sample embodiments, the alignment subsystem is customized to portion of the hand of a specific individual.

摘要翻译： 本发明涉及通过测定样品对入射辐射的响应，更确切地说，涉及人体组织中分析物如葡萄糖或醇的测量来测量材料性质。 本发明的一些示例性实施例提供一种包括光学子系统的光采样装置，其具有用于接收从组织表达的光的接收器; 以及对准子系统，其适于将与所述对准子系统处于可操作关系的手的一部分相对于所述接收器推定为限定的配置。 在一些这样的示例性实施例中，对准子系统包括具有多个突起的衬底，该突出部设置成图案，使得突起将放置在衬底上的手的一部分相对于接收器推压到限定的构型。 在一些这样的示例性实施例中，对准子系统包括具有限定近似手部的形状的体积的表面的衬底，使得该体积将其中放置的手的一部分相对于接收器施加到限定的构型。 在一些这样的示例性实施例中，对准子系统包括具有大致U形横截面并延伸一定距离的表面，其中相对于采样装置安装表面，使得手指放置在U形横截面 的表面被推动到相对于接收器的限定的配置。 在一些这样的示例性实施例中，对准子系统被定制为特定个体的手的部分。