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    Alignment System for Optically Sampling a Hand
    2.
    发明申请
    Alignment System for Optically Sampling a Hand 审中-公开
    用于光学取样的对准系统

    公开(公告)号：US20100113899A1

    公开(公告)日：2010-05-06

    申请号：US12614056

    申请日：2009-11-06

    申请人： Mark Ries Robinson ,  Andrea Magee ,  Michael U. Haass ,  Russell E. Abbink ,  William Radigan ,  V. Gerald Grafe

    发明人： Mark Ries Robinson ,  Andrea Magee ,  Michael U. Haass ,  Russell E. Abbink ,  William Radigan ,  V. Gerald Grafe

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6825 ,  A61B5/6826 ,  A61B5/6838

    摘要： This invention relates to measurements of material properties by determination of the response of a sample to incident radiation, and more specifically to the measurement of analytes such as glucose or alcohol in human tissue. Some example embodiments of the present invention provide an optical sampling apparatus including an optical subsystem, having a receiver for receiving light expressed from tissue; and an alignment subsystem, adapted to urge a portion of a hand placed in operative relationship with the alignment subsystem into a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a substrate having a plurality of projections therefrom disposed in a pattern such that the projections urge a portion of a hand placed on the substrate to a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a substrate having a surface defining a volume approximating the shape of a portion of a hand such that the volume urges a portion of a hand placed therein to a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a surface having a generally U-shaped cross-section and extending for a distance, wherein the surface is mounted relative to the sampling means such that a finger placed in the U-shaped cross-section of the surface is urged to a defined configuration relative to the receiver. In some such sample embodiments, the alignment subsystem is customized to portion of the hand of a specific individual.

    摘要翻译： 本发明涉及通过测定样品对入射辐射的响应，更确切地说，涉及人体组织中分析物如葡萄糖或醇的测量来测量材料性质。 本发明的一些示例性实施例提供一种包括光学子系统的光采样装置，其具有用于接收从组织表达的光的接收器; 以及对准子系统，其适于将与所述对准子系统处于可操作关系的手的一部分相对于所述接收器推定为限定的配置。 在一些这样的示例性实施例中，对准子系统包括具有多个突起的衬底，该突出部设置成图案，使得突起将放置在衬底上的手的一部分相对于接收器推压到限定的构型。 在一些这样的示例性实施例中，对准子系统包括具有限定近似手部的形状的体积的表面的衬底，使得该体积将其中放置的手的一部分相对于接收器施加到限定的构型。 在一些这样的示例性实施例中，对准子系统包括具有大致U形横截面并延伸一定距离的表面，其中相对于采样装置安装表面，使得手指放置在U形横截面 的表面被推动到相对于接收器的限定的配置。 在一些这样的示例性实施例中，对准子系统被定制为特定个体的手的部分。

    Method of generating interferometric information
    4.
    发明授权
    Method of generating interferometric information 失效
    产生干涉信息的方法

    公开(公告)号：US07388669B2

    公开(公告)日：2008-06-17

    申请号：US11204278

    申请日：2005-08-15

    申请人： Russell E. Abbink

    发明人： Russell E. Abbink

    IPC分类号： G01B9/02 ,  G01J3/45 ,  G01N21/41 ,  G01N21/43

    CPC分类号： G01J3/453

    摘要： The present invention provides methods for generating interferometric information. Interferometric information from refractively scanned interferometers can contain errors due to wavelength-dependent refractive indices. The wavelength-dependent refractive indices of elements of the interferometer can produce errors when the OPD at a reference wavelength is different than the OPD at a sample wavelength. The invention can provide correction of interferometric information using relationships between the OPD at the wavelengths of interest, which correction can also be dependent on physical relationships among elements of the interferometer.

    摘要翻译： 本发明提供了用于产生干涉信息的方法。 来自折射扫描干涉仪的干涉测量信息可能会由于波长依赖的折射率而含有误差。 当参考波长的OPD与样品波长处的OPD不同时，干涉仪的元件的波长相关折射率可能产生误差。 本发明可以使用感兴趣波长处的OPD之间的关系来提供干涉信息的校正，该校正也可以取决于干涉仪的元件之间的物理关系。

    Methods and Apparatuses for Noninvasive Determinations of Analytes
    5.
    发明申请
    Methods and Apparatuses for Noninvasive Determinations of Analytes 有权
    无创测定分析物的方法和设备

    公开(公告)号：US20140303463A1

    公开(公告)日：2014-10-09

    申请号：US14250125

    申请日：2014-04-10

    申请人： M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

    发明人： M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

    IPC分类号： A61B5/1455 ,  A61B5/145

    CPC分类号： A61B5/14552 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14558 ,  A61B5/7257 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0262 ,  G01N21/21 ,  G01N21/49 ,  G01N2021/4792

    摘要： The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness.

    摘要翻译： 本发明提供用于精确无创确定组织性质的方法和装置。 本发明的一些实施例包括具有照明子系统的光学采样器，适于将具有第一偏振光的光传送到组织表面; 收集子系统，适于在与所述组织相互作用之后收集从所述组织传递的具有第二极化的光; 其中所述第一极化不同于所述第二极化。 极化的差异可以阻止从组织表面反射的光的收集，并且可以鼓励优先收集与组织中所需的穿透深度或路径长度分布相互作用的光。 作为示例，不同的极化可以是具有不同手性的角度或椭圆偏振之间的线性偏振。

    Interferometer alignment
    6.
    发明授权
    Interferometer alignment 失效
    干涉仪校准

    公开(公告)号：US06952266B2

    公开(公告)日：2005-10-04

    申请号：US10342578

    申请日：2003-01-15

    申请人： Russell E. Abbink

    发明人： Russell E. Abbink

    IPC分类号： G01B9/02

    CPC分类号： G01B9/02061

    摘要： The present invention provides means for correcting interferometer alignment errors through the use of corrective elements. The corrective elements allow reduced accuracy in the assembly process. Residual alignment errors caused by imprecise mounting of permanently mounted components can be corrected using relatively low precision positioning of corrector components. The technique can be particularly applicable to the mass production of interferometers, for which achieving and maintaining the required assembly tolerances might otherwise be prohibitively expensive. Interferometers according to the present invention can be used, for example, in optical spectroscopy and in interferometers.

    摘要翻译： 本发明提供了通过使用校正元件来校正干涉仪校准误差的装置。 校正元件允许在组装过程中降低精度。 可以使用校正部件的相对较低的精度定位来校正由永久安装的部件的不精确安装引起的残余对准误差。 该技术可以特别适用于大规模生产干涉仪，其中实现和保持所需的组装公差可能会非常昂贵。 根据本发明的干涉仪可以用于例如光谱学和干涉仪中。

    Illumination source and non-invasive tissue sampling system
    7.
    发明授权
    Illumination source and non-invasive tissue sampling system 失效
    照明源和非侵入性组织采样系统

    公开(公告)号：US08102531B2

    公开(公告)日：2012-01-24

    申请号：US11611133

    申请日：2006-12-15

    申请人： Russell E. Abbink ,  Andrew D. Meigs

    发明人： Russell E. Abbink ,  Andrew D. Meigs

    IPC分类号： G01N21/00

    CPC分类号： G01J1/08 ,  G01J1/04 ,  G01J1/0422 ,  G01J1/0474 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0216 ,  G01J3/0254 ,  G01J3/10 ,  G01J2001/0481

    摘要： The present invention provides an optical transmission device, comprising a chamber having a light input into the chamber, and having a first port allowing light to pass out of the chamber, and comprising internal surfaces where at least a portion of the surfaces is diffusely reflecting, and where at least a portion of the one or more surfaces is specularly reflecting, and where the light input and the first port and the one or more surfaces are configured such that substantially all light entering the chamber via the light source within a first predetermined aperture must encounter the diffusely reflecting portion before exiting the chamber via the first port within a second predetermined aperture. The invention can provide substantially homogenous light transmission, both as a source of light for optical systems and as a collector of light from a sample.

    摘要翻译： 本发明提供了一种光传输装置，其包括具有入射到室中的光的腔室，并且具有允许光从腔室中流出的第一端口，并且包括至少部分表面漫反射的内表面， 并且其中所述一个或多个表面的至少一部分是镜面反射的，并且其中所述光输入和所述第一端口以及所述一个或多个表面被配置为使得基本上所有的光经由所述光源在第一预定孔内进入所述室 必须在第二预定孔径内经由第一端口离开室之前遇到漫反射部分。 本发明可以提供基本均匀的光透射，既作为光学系统的光源又作为来自样品的光的收集器。

    Illumination Source and Non-invasive Tissue Sampling System
    10.
    发明申请
    Illumination Source and Non-invasive Tissue Sampling System 失效
    照明源和非侵入性组织采样系统

    公开(公告)号：US20080146909A1

    公开(公告)日：2008-06-19

    申请号：US11611133

    申请日：2006-12-15

    申请人： Russell E. Abbink ,  Andrew D. Meigs

    发明人： Russell E. Abbink ,  Andrew D. Meigs

    IPC分类号： G01J3/00

    CPC分类号： G01J1/08 ,  G01J1/04 ,  G01J1/0422 ,  G01J1/0474 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0216 ,  G01J3/0254 ,  G01J3/10 ,  G01J2001/0481

    摘要： The present invention provides an optical transmission device, comprising a chamber having a light input into the chamber, and having a first port allowing light to pass out of the chamber, and comprising internal surfaces where at least a portion of the surfaces is diffusely reflecting, and where at least a portion of the one or more surfaces is specularly reflecting, and where the light input and the first port and the one or more surfaces are configured such that substantially all light entering the chamber via the light source within a first predetermined aperture must encounter the diffusely reflecting portion before exiting the chamber via the first port within a second predetermined aperture. The invention can provide substantially homogenous light transmission, both as a source of light for optical systems and as a collector of light from a sample.

    摘要翻译： 本发明提供了一种光传输装置，其包括具有入射到室中的光的腔室，并且具有允许光从腔室中流出的第一端口，并且包括至少部分表面漫反射的内表面， 并且其中所述一个或多个表面的至少一部分是镜面反射的，并且其中所述光输入和所述第一端口以及所述一个或多个表面被配置为使得基本上所有的光经由所述光源在第一预定孔内进入所述室 必须在第二预定孔径内经由第一端口离开室之前遇到漫反射部分。 本发明可以提供基本均匀的光透射，既作为光学系统的光源又作为来自样品的光的收集器。