专利检索 ap:"William Ronald Solvibile, JR." 第 1 页

1.

发明授权
Amino-pyridines as inhibitors of β-secretase 失效
标题翻译：氨基吡啶作为抑制剂和分泌酶

公开(公告)号：US07732457B2

公开(公告)日：2010-06-08

申请号：US11344432

申请日：2006-01-31

申请人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, Jr. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud

发明人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, Jr. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud

IPC分类号： A61K31/506 , C07D401/14

CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14

摘要： The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.

摘要翻译： 本发明提供式I的氨基 - 吡啶化合物本发明还提供了其用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的方法。

2.

发明申请
Amino-pyridines As Inhibitors Of Beta-secretase 审中-公开
标题翻译：氨基吡啶作为β分泌酶的抑制剂

公开(公告)号：US20100204245A1

公开(公告)日：2010-08-12

申请号：US12763612

申请日：2010-04-20

申请人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, JR. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud

发明人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, JR. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud

IPC分类号： A61K31/497 , C07D401/06 , A61K31/4439 , C07D401/12 , A61K31/444 , A61K31/506 , A61P25/28 , C12N5/071

CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14

摘要： The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.

摘要翻译： 本发明提供式I的氨基 - 吡啶化合物本发明还提供了其用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的方法。

3.

发明授权
Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators 失效
标题翻译：取代的噻吩基和呋喃基酰基胍及其用作β-分泌酶调节剂的方法

公开(公告)号：US07459567B2

公开(公告)日：2008-12-02

申请号：US11352646

申请日：2006-02-13

申请人： William Floyd Fobare , William Ronald Solvibile, Jr.

发明人： William Floyd Fobare , William Ronald Solvibile, Jr.

IPC分类号： C07D333/02 , A01N43/02

CPC分类号： C07D333/24 , C07D307/52 , C07D409/12

摘要： The present invention provides a substituted thienyl or furyl acylguanidine compound of formula I The present invention also provides methods for the inhibition of β-secretase (BACE) and for the treatment of β-amyloid deposits and neurofibrillary tangles.

摘要翻译： 本发明提供式I的取代的噻吩基或呋喃基酰基胍化合物本发明还提供抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。