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公开(公告)号：US20100204245A1
公开(公告)日：2010-08-12
申请号：US12763612
申请日：2010-04-20
申请人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, JR. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
发明人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, JR. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
IPC分类号： A61K31/497 , C07D401/06 , A61K31/4439 , C07D401/12 , A61K31/444 , A61K31/506 , A61P25/28 , C12N5/071
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14
摘要： The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的氨基 - 吡啶化合物本发明还提供了其用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的方法。
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公开(公告)号：US07732457B2
公开(公告)日：2010-06-08
申请号：US11344432
申请日：2006-01-31
申请人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, Jr. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
发明人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, Jr. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
IPC分类号： A61K31/506 , C07D401/14
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14
摘要： The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的氨基 - 吡啶化合物本发明还提供了其用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的方法。
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公开(公告)号：US07488832B2
公开(公告)日：2009-02-10
申请号：US11352820
申请日：2006-02-13
申请人： Derek Cecil Cole , Eric Steven Manas , Lee Dalton Jennings , Frank Eldridge Lovering , Joseph Raymond Stock , William Jay Moore , John Watson Ellingboe , Jeffrey Scott Condon , Mohani Nirmala Sukhdeo , Ping Zhou , Junjun Wu , Koi Michele Morris
发明人： Derek Cecil Cole , Eric Steven Manas , Lee Dalton Jennings , Frank Eldridge Lovering , Joseph Raymond Stock , William Jay Moore , John Watson Ellingboe , Jeffrey Scott Condon , Mohani Nirmala Sukhdeo , Ping Zhou , Junjun Wu , Koi Michele Morris
IPC分类号： C07D207/325 , A61K31/4025
CPC分类号： C07D207/327 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/337 , C07D207/36 , C07D401/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供了式I的吡唑基酰基喹啉化合物。本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。
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公开(公告)号：US20080287424A1
公开(公告)日：2008-11-20
申请号：US12173303
申请日：2008-07-15
申请人： Derek Cecil Cole , Eric Steven Manas , Lee Dalton Jennings , Frank Eldridge Lovering , Joseph Raymond Stock , William Jay Moore , John Watson Ellingboe , Jeffrey Scott Condon , Mohani Nirmala Sukhdeo , Ping Zhou , Junjun Wu , Koi Michele Morris
发明人： Derek Cecil Cole , Eric Steven Manas , Lee Dalton Jennings , Frank Eldridge Lovering , Joseph Raymond Stock , William Jay Moore , John Watson Ellingboe , Jeffrey Scott Condon , Mohani Nirmala Sukhdeo , Ping Zhou , Junjun Wu , Koi Michele Morris
IPC分类号： A61K31/541 , A61K31/40 , C07D207/327 , C07D401/10 , A61P25/28 , C12N9/99 , A61K31/454 , C07D417/10
CPC分类号： C07D207/327 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/337 , C07D207/36 , C07D401/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供了式I的吡唑基酰基喹啉化合物。本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。
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