公开(公告)号：US5462536A

公开(公告)日：1995-10-31

申请号：US91532

申请日：1993-07-14

申请人： James A. Braatz ,  Clifton L. Kehr ,  Timothy G. Grasel ,  William S. Letter

发明人： James A. Braatz ,  Clifton L. Kehr ,  Timothy G. Grasel ,  William S. Letter

IPC分类号： A61L15/26 ,  A61F13/00 ,  A61F13/02

CPC分类号： A61L15/26

摘要： Controlled release membranes are prepared from polyureaurethane polymer derived from prepolymer units at least 75% of which are oxyethylene-based diols or polyols having essentially all of the hydroxyl groups capped with polyisocyanate are disclosed. The membranes are characterized by their biocompatibility and resistance to nonspecific protein adsorption and are particuarly useful for delivery of proteinaceous materials in drug-delivery systems, i.e., wound dressings. Also disclosed are novel biocompatible, protein-nonadsorptive hydrated polymers and the method of producing the same.

摘要翻译： 公开了控制释放膜，其由衍生自预聚物单元的聚脲聚氨酯聚合物制备，其中至少75％是基于氧化乙烯的二醇或基本上具有用多异氰酸酯封端的羟基的多元醇。 膜的特征在于它们的生物相容性和对非特异性蛋白质吸附的抗性，并且对于在药物递送系统（即伤口敷料）中递送蛋白质材料是特别有用的。 还公开了新的生物相容性，蛋白质 - 非吸收性水合聚合物及其制备方法。