公开(公告)号：US20070060525A1

公开(公告)日：2007-03-15

申请号：US11225748

申请日：2005-09-13

申请人： William Simmons

发明人： William Simmons

IPC分类号： A61K38/05 ,  C07K5/06

CPC分类号： A61K38/556 ,  C07K5/0202 ,  C07K5/0823 ,  A61K2300/00

摘要： The present invention is directed to an α thio-containing compound that is capable of inhibiting the enzyme, membrane aminopeptidase P (mAPP or APP), whose natural substrate is bradykinin. The compound is useful as a pharmaceutical agent because by inhibiting bradykinin degradation, the compound allows bradykinin to exert its beneficial effects on the cardiovascular system, to improve renal function, and to improve glucose tolerance and insulin-sensitivity. The present invention is also directed to a pharmaceutical composition comprising the mAPP inhibitor of the present invention and a pharmaceutically acceptable carrier. In another aspect, the present invention is directed to a method of inhibiting bradykinin degradation in a mammalian patient, preferably human, in need of treatment comprising administering to the patient a therapeutically effective amount of an α thio-containing compound of the present invention. The method of the present invention also contemplates the further step of administering to the mammalian patient in need of treatment a therapeutically effective amount of an inhibitor of angiotensin converting enzyme (ACE).

摘要翻译： 本发明涉及能够抑制其天然底物是缓激肽的酶的氨基肽酶P（mAPP或APP）的能够抑制酶的α硫代化合物。 该化合物可用作药剂，因为通过抑制缓激肽降解，该化合物允许缓激肽对心血管系统发挥有益作用，改善肾功能，并改善葡萄糖耐量和胰岛素敏感性。 本发明还涉及包含本发明的mAPP抑制剂和药学上可接受的载体的药物组合物。 另一方面，本发明涉及在需要治疗的哺乳动物患者，优选人类中抑制缓激肽降解的方法，包括向患者施用治疗有效量的本发明的含α硫代化合物。 本发明的方法还考虑到需要治疗哺乳动物患者治疗有效量的血管紧张素转化酶（ACE）抑制剂的进一步步骤。

公开(公告)号：US5403866A

公开(公告)日：1995-04-04

申请号：US108173

申请日：1993-08-18

申请人： Yoshiyuki Kato ,  Hideaki Shibata ,  William Simmons ,  Nigel K. Graham

发明人： Yoshiyuki Kato ,  Hideaki Shibata ,  William Simmons ,  Nigel K. Graham

IPC分类号： B22C7/02 ,  C08J9/14 ,  C08J9/20

CPC分类号： C08J9/20 ,  B22C7/023 ,  C08J9/14 ,  C08J2325/14 ,  Y10S525/902 ,  Y10T428/249953 ,  Y10T428/249954

摘要： Disclosed are a foamable resin composition which comprises a copolymer with a weight-average molecular weight of 150,000-350,000 produced by copolymerization of a monomer mixture of 55-85% by weight of styrene and 45-15% by weight of a methacrylic acid ester represented by general formula (I)CH.sub.2 .dbd.C(CH.sub.3)COOR (I)(wherein R represents a C.sub.1-4 alkyl group) and, having impregnated therein, 10% by weight or less of a foaming agent relative to said monomer mixture, a thermoplastic foamable pattern which is constituted by heating, foaming and molding of a foamable resin composition as claimed in claim 1, a metal casting manufacturing method which comprises a stage wherein a thermoplastic foamable pattern as claimed in claim 9 is especially surrounded by refractory material and a stage wherein molten metal is poured into said pattern in order to eliminate said pattern and, as the result of solidification of said metal, form a casting as a reproduction of said pattern, and a metal casting manufacturing method which comprises a stage wherein a thermoplastic foamable pattern as claimed in claim 9 is especially surrounded by refractory material, a stage wherein said pattern is eliminated to form a space, a stage wherein molten metal is poured into said space and a stage wherein a casting is formed as a reproduction of said pattern by solidification of said metal.

摘要翻译： 公开了一种可发泡树脂组合物，其包含通过55-85重量％的苯乙烯和45-15重量％的甲基丙烯酸酯的单体混合物的共聚产生的重均分子量为150,000-350,000的共聚物 通式（I）CH 2 = C（CH 3）COOR（I）（其中R表示C 1-4烷基），并且其中浸渍有相对于所述单体混合物为10重量％以下的发泡剂， 权利要求1所述的可发泡树脂组合物的加热，发泡和模塑构成的热塑性可发泡图案，其特征在于，包括如权利要求9所述的热塑性可发泡图案特别被难熔材料包围的阶段， 将熔融金属倒入所述图案的阶段，以消除所述图案，并且由于所述金属的凝固形成铸件作为所述图案的再现，并且金属铸造制品 其中包括一个阶段，其中如权利要求9所述的热塑性可发泡图案特别被耐火材料包围，其中所述图案被消除以形成空间的阶段，其中将熔融金属倒入所述空间中的阶段和其中 铸造通过所述金属的固化形成为所述图案的再现。

公开(公告)号：US4430123A

公开(公告)日：1984-02-07

申请号：US290802

申请日：1981-08-05

申请人： William Simmons

发明人： William Simmons

IPC分类号： C21C1/10 ,  C21C1/08 ,  C22C33/08 ,  C22C37/00

CPC分类号： C21C1/08 ,  C22C33/08 ,  C22C37/00

摘要： Vermicular graphite cast iron is produced by adding to molten iron simultaneously up to 0.3% by weight of the iron of one or more rare earth metals and in excess of 0.2% by weight of the iron of calcium the quantity of rare earth metal being within the range of 2 to 8 times the sulphur content of the molten iron.The rare earth may be added for example as cerium, mischmetall or as rare earth silicide. The calcium may be added for example as calcium metal or as calcium silicide or a nickel-calcium alloy. An alloy containing both rare earth and calcium, such as a calcium-cerium-silicon alloy, or a composition containing rare earth, calcium and a fluxing agent may also be used.

摘要翻译： PCT No.PCT / GB80 / 00193 Sec。 371日期1981年8月5日 102（e）日期1981年8月5日PCT提交1980年11月5日PCT公布。 公开号WO81 / 01861 日期：1981年7月9日。通过向铁水中同时加入至少0.3重量％的一种或多种稀土金属的铁和超过钙的0.2重量％的量来生产电铸石墨铸铁 的稀土金属在铁水的硫含量的2至8倍的范围内。 稀土可以添加为例如铈，稀土金属或稀土硅化物。 钙可以例如作为钙金属或作为硅化钙或镍 - 钙合金添加。 还可以使用包含稀土和钙的合金，例如钙 - 铈 - 硅合金，或含有稀土，钙和助熔剂的组合物。

公开(公告)号：US1393841A

公开(公告)日：1921-10-18

申请号：US38437520

申请日：1920-05-26

申请人： WILLIAM SIMMONS LEON

发明人： WILLIAM SIMMONS LEON

IPC分类号： A46B11/00

CPC分类号： A46B11/0013

公开(公告)号：USD287766S

公开(公告)日：1987-01-13

申请号：US581308

申请日：1984-02-17

申请人： William Simmons

设计人： William Simmons

公开(公告)号：US4029140A

公开(公告)日：1977-06-14

申请号：US656872

申请日：1976-02-10

申请人： William Simmons

发明人： William Simmons

IPC分类号： B22C3/00 ,  B22D27/20 ,  C22C33/08

CPC分类号： C22C33/08 ,  B22C3/00 ,  B22D27/20

摘要： In an iron molding process and in a mold for carrying out the process, in which the mold is at least locally coated with tellurium or bismuth to promote the production of a white iron structure there is included in the coating a mineral substance such as a clay containing water which is loosely chemically combined, or a substance containing hydroxyl groups, the water or each hydroxyl group being chemically combined tightly enough so that it withstands the heat involved in drying of the mold but is liberated on contact with the molten iron.

摘要翻译： 在铁成型工艺中和用于实施该方法的模具中，其中模具至少局部涂覆有碲或铋以促进白铁结构的生产，其中包括一种矿物质如粘土 含有松散化学组合的水，或含有羟基的物质，水或每个羟基的化学组合足够紧密，以便它能承受模具干燥所涉及的热量，但在与铁水接触时释放。

公开(公告)号：US2052493A

公开(公告)日：1936-08-25

申请号：US1890735

申请日：1935-04-29

申请人： WILLIAM SIMMONS

发明人： WILLIAM SIMMONS

IPC分类号： D03D39/16

CPC分类号： D03D39/16

公开(公告)号：US1511375A

公开(公告)日：1924-10-14

申请号：US60325322

申请日：1922-11-25

申请人： WILLIAM SIMMONS

发明人： WILLIAM SIMMONS

IPC分类号： D03D35/00

CPC分类号： D03D35/005

公开(公告)号：US07230181B2

公开(公告)日：2007-06-12

申请号：US11088170

申请日：2005-03-23

申请人： Joseph William Simmons ,  Randall Wade Hatfield

发明人： Joseph William Simmons ,  Randall Wade Hatfield

IPC分类号： H01R13/72

CPC分类号： B65H75/36 ,  B65H2701/34 ,  H01R13/60 ,  H02G11/02

摘要： A cord holding device and method of use. An embodiment of the device includes a sheet of material having a turned end. The turned end is selectively positionable between a closed orientation and an open orientation. In the open orientation, an opening is formed between the turned end and the sheet to allow for the cord to be inserted within an interior section. In the closed orientation, the turned end wraps around the cord to retain it within the device. A method of using the device comprises mounting the device to a position to receive the cord. A holding section is unturned an amount to allow for the cord to be inserted within the interior section of the holding section. After cord insertion, the holding section re-turns and wraps around the cord.

摘要翻译： 一种帘线保持装置及其使用方法。 该装置的实施例包括具有转动端的材料片。 转动端可以选择性地定位在闭合取向和打开取向之间。 在打开的方向上，在转动的端部和片材之间形成开口以允许绳索插入到内部部分内。 在封闭的方向，转动的端部缠绕在电线上以将其保持在设备内。 使用该装置的方法包括将装置安装到接收绳索的位置。 保持部分是一个允许将电线插入到保持部分的内部部分内的量。 电源线插入后，保持部分重新转动并缠绕在电线上。

公开(公告)号：US20060086862A1

公开(公告)日：2006-04-27

申请号：US11009455

申请日：2004-12-10

申请人： Joey Konkel ,  Murray Neal ,  William Simmons

发明人： Joey Konkel ,  Murray Neal ,  William Simmons

IPC分类号： B65H49/18

CPC分类号： B65H49/327 ,  B65H49/32

摘要： A rod is coupled to a frame to hold a wire reel that is to be loaded onto it. A roller is coupled to the frame so that its radial surface stays in contact with a radial surface of a spool wall of the loaded reel, as the loaded reel rotates. Other embodiments are also described and claimed.

摘要翻译： 杆连接到框架以保持待加载到其上的线卷轴。 当加载的卷轴旋转时，辊被联接到框架，使得其径向表面与加载的卷轴的卷轴壁的径向表面保持接触。 还描述和要求保护其他实施例。