公开(公告)号：US10130696B2

公开(公告)日：2018-11-20

申请号：US12678813

申请日：2008-09-18

Applicant: Charles Richardson ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William Tino

Inventor： Charles Richardson ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William Tino

IPC: A61K39/12 ,  C12N7/00 ,  A61K39/00

Abstract: The present invention relates to vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to methods of conferring protective immunity to Norovirus infections in a human subject.

公开(公告)号：US20070128671A1

公开(公告)日：2007-06-07

申请号：US11150507

申请日：2005-06-09

Applicant: Gerald Murphy ,  Alton Boynton ,  Eric Holmes ,  William Tino

Inventor： Gerald Murphy ,  Alton Boynton ,  Eric Holmes ,  William Tino

IPC: G01N33/574

CPC classification number: C07K16/28 ,  A61K49/0058 ,  A61K51/1027 ,  A61K51/1072 ,  C07K16/3069 ,  C07K2317/34 ,  C12N2799/026 ,  G01N33/57434

Abstract: The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM′) of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM′ allows the use of an immunoenzymatic assay for their detection.

Abstract translation: 本发明涉及结合前列腺特异性膜抗原（PSMA）的细胞外结构域的单克隆抗体，产生抗体的杂交瘤细胞系，以及使用这种抗体诊断和治疗癌症的方法。 特别地，示例了在细胞表面上表达的与PSMA反应的三十五种单克隆抗体。 另外，本发明涉及由本发明的许多抗体检测的PSMA的新型蛋白质变体（PSM'）。 PSMA和PSM'的水解酶活性允许使用免疫酶测定法进行检测。