公开(公告)号：US20070128671A1

公开(公告)日：2007-06-07

申请号：US11150507

申请日：2005-06-09

Applicant: Gerald Murphy ,  Alton Boynton ,  Eric Holmes ,  William Tino

Inventor： Gerald Murphy ,  Alton Boynton ,  Eric Holmes ,  William Tino

IPC: G01N33/574

CPC classification number: C07K16/28 ,  A61K49/0058 ,  A61K51/1027 ,  A61K51/1072 ,  C07K16/3069 ,  C07K2317/34 ,  C12N2799/026 ,  G01N33/57434

Abstract: The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM′) of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM′ allows the use of an immunoenzymatic assay for their detection.

Abstract translation: 本发明涉及结合前列腺特异性膜抗原（PSMA）的细胞外结构域的单克隆抗体，产生抗体的杂交瘤细胞系，以及使用这种抗体诊断和治疗癌症的方法。 特别地，示例了在细胞表面上表达的与PSMA反应的三十五种单克隆抗体。 另外，本发明涉及由本发明的许多抗体检测的PSMA的新型蛋白质变体（PSM'）。 PSMA和PSM'的水解酶活性允许使用免疫酶测定法进行检测。

公开(公告)号：US08435435B2

公开(公告)日：2013-05-07

申请号：US12295416

申请日：2007-03-30

Applicant: Daniel Dearing ,  Eric Holmes ,  Markus Fischer

Inventor： Daniel Dearing ,  Eric Holmes ,  Markus Fischer

IPC: B29C45/14 ,  B29C39/10

CPC classification number: B22D19/02 ,  B22D17/24 ,  B29C45/1657 ,  B29C2045/1696

Abstract: Disclosed is a method for manufacturing a multilayered duplex material article. The method comprises providing a first layer from a non-cast material and a second layer from a cast material wherein the second layer is made from a material with a lower melting point than the first layer. In one embodiment the first layer is a wrought alloy and the second layer is cast onto the first layer.

Abstract translation: 公开了一种制造多层双面材料制品的方法。 该方法包括从非铸造材料提供第一层和从铸造材料提供第二层，其中第二层由具有比第一层低的熔点的材料制成。 在一个实施例中，第一层是锻造合金，第二层被浇铸到第一层上。

公开(公告)号：US20090140506A1

公开(公告)日：2009-06-04

申请号：US12328252

申请日：2008-12-04

Applicant: Markus Fischer ,  Eric Holmes

Inventor： Markus Fischer ,  Eric Holmes

IPC: B60G17/00

CPC classification number: B60G7/003 ,  B60G2206/1112 ,  B60G2206/8207

Abstract: A toe link for the suspension system of a vehicle includes means for adjusting the axial length of the toe link while preventing relative rotation of the extending ends of the toe link.

Abstract translation: 用于车辆的悬挂系统的脚趾连杆包括用于在防止脚趾连杆的延伸端的相对旋转的同时调节脚趾连杆的轴向长度的装置。

公开(公告)号：US20070110510A1

公开(公告)日：2007-05-17

申请号：US11266869

申请日：2005-11-03

Applicant: Eric Holmes ,  Frank Fehre ,  Markus Fischer

Inventor： Eric Holmes ,  Frank Fehre ,  Markus Fischer

IPC: F16C11/00

CPC classification number: F16C11/0614 ,  F16C11/0671 ,  F16J3/042 ,  Y10T403/31 ,  Y10T403/315 ,  Y10T403/32631 ,  Y10T403/32729

Abstract: A ball joint, is provided in the form of a cross axis joint with a housing, a bearing shell in the housing and a ball sleeve. The ball sleeve includes a ball portion with a bearing surface cooperating with the bearing shell and a first pivot pin and a second pivot pin extending from said ball portion in an axial direction. The ball sleeve has an inner surface defining a through hole (50) for receipt of a connection bolt. The first pivot pin has a first end with a first outer surface (42) and a first annular end face (41) and the second pivot pin has a second end with a second outer surface (44) and a second annular end face (43). Sealing rings (60, 60′, 60″, 90, 95) are provided, each having a first axially extending portion extending along the first outer surface and having a sealing area outer surface defining a bellows seal seat (64, 98) and a radially extending portion extending along the end face. Each bellows seal (52, 54) is connected to the housing at one end and connected to said bellows seal seat (64, 98) at another end.

Abstract translation: 球形接头以具有壳体的轴向接合件的形式提供，壳体中的轴承壳体和球套筒。 所述球套包括具有与所述轴承壳配合的轴承面的球部，以及从所述球部沿轴向延伸的第一枢轴销和第二枢转销。 球套具有限定用于接收连接螺栓的通孔（50）的内表面。 第一枢转销具有带有第一外表面（42）和第一环形端面（41）的第一端，第二枢转销具有带有第二外表面（44）和第二环形端面（43）的第二端 ）。 提供密封环（60,60'，60“，90,95），每个密封环具有沿着第一外表面延伸的第一轴向延伸部分，并且具有限定波纹管密封座（64,98）的密封区域外表面， 沿着端面延伸的径向延伸部分。 每个波纹管密封件（52,54）在一端连接到壳体，并在另一端连接到所述波纹管密封座（64,98）。

公开(公告)号：US07195416B2

公开(公告)日：2007-03-27

申请号：US10664703

申请日：2003-09-18

Applicant: Eric Holmes

Inventor： Eric Holmes

IPC: F16C11/00

CPC classification number: F16C11/0633 ,  Y10T403/32631 ,  Y10T403/32721 ,  Y10T403/32737

Abstract: A ball-and-socket joint for motor vehicles provided, with a joint ball and a pivot pin, a housing part formed of a shaped metal tube having a top end with an opening and having an opposite end with a pivot pin opening through which the pivot pin protrudes and with a molded material molded on a portion of the housing, the molded on material forming functional surfaces on each of an inside and an outside of the housing part.

Abstract translation: 一种用于机动车辆的球窝接头，其具有接头球和枢转销，壳体部分由具有开口的顶端形成的成形金属管形成，并且具有与枢轴销开口相对的端部， 枢轴销突出并且模制在壳体的一部分上的模制材料，模制的材料在壳体部分的内部和外部的每一个上形成功能表面。

公开(公告)号：US20050063769A1

公开(公告)日：2005-03-24

申请号：US10664703

申请日：2003-09-18

Applicant: Eric Holmes

Inventor： Eric Holmes

IPC: F16C11/06 ,  F16C11/08 ,  F16D1/12

CPC classification number: F16C11/0633 ,  Y10T403/32631 ,  Y10T403/32721 ,  Y10T403/32737

Abstract: The invention pertains to a ball-and-socket joint for motor vehicles, with a joint ball and a pivot pin, a housing part formed of a shaped metal tube having a top end with an opening and having an opposite end with a pivot pin opening through which the pivot pin protrudes and with a molded material molded on a portion of the housing, the molded on material forming functional surfaces on each of an inside and an outside of the housing part.

Abstract translation: 本发明涉及用于机动车辆的球窝接头，其具有接头球和枢轴销，壳体部分由成形金属管形成，该金属管的顶端具有开口，并具有与枢轴销开口相对的端部 枢轴销通过其突出并且模制在壳体的一部分上的模制材料，模制的材料在壳体部分的内部和外部的每一个上形成功能表面。

公开(公告)号：US20060157492A1

公开(公告)日：2006-07-20

申请号：US11384660

申请日：2006-03-20

Applicant: Paul Shows ,  Steven Remis ,  Curtis Akins ,  Robert Parks ,  Ryan Kaintz ,  Eric Holmes ,  Matthew Beale ,  Matthew Sass

Inventor： Paul Shows ,  Steven Remis ,  Curtis Akins ,  Robert Parks ,  Ryan Kaintz ,  Eric Holmes ,  Matthew Beale ,  Matthew Sass

IPC: G07F11/00

CPC classification number: G06F19/3462 ,  G05B15/02 ,  G06F19/00 ,  G07F5/18 ,  G07F5/26 ,  G07F9/026 ,  G07F11/002 ,  G07F11/24 ,  G07F11/30 ,  G07F11/42 ,  G07F11/44 ,  G07F11/54 ,  G07F11/62 ,  G07F17/0092

Abstract: A method of dispensing medicaments may employ a drug dispensing device comprised of an upper hopper having an upper opening for receiving a medicament and a lower opening. The drug dispensing device also includes a lower hopper having an upper opening and a lower opening in a bottom portion thereof. The upper hopper defines a bulk storage chamber and the lower hopper defines a dispensing chamber. A rotatable dispensing disc is positioned in a lower portion of the dispensing chamber for dispensing medicament from the drug dispensing device through the lower opening in the lower hopper. A regulator is situated between the bulk storage chamber and the dispensing chamber for controlling the rate at which medicament moves from the storage chamber to the dispensing chamber.

Abstract translation: 分配药物的方法可以使用药物分配装置，其包括具有用于接收药物的上开口的上料斗和下开口。 药物分配装置还包括在其底部具有上开口和下开口的下料斗。 上料斗限定大容量储存室，下料斗限定分配室。 可旋转分配盘定位在分配室的下部，用于通过下料斗中的下开口从药物分配装置分配药物。 调节器位于大容量储存室和分配室之间，用于控制药物从储存室移动到分配室的速率。

公开(公告)号：US06966559B1

公开(公告)日：2005-11-22

申请号：US10896498

申请日：2004-07-22

Applicant: Markus Fischer ,  Eric Holmes ,  Daniel Dearing

Inventor： Markus Fischer ,  Eric Holmes ,  Daniel Dearing

IPC: F16C11/06 ,  F16C33/10 ,  F16D3/84 ,  F16J3/04 ,  F16J15/32

CPC classification number: F16J3/046 ,  F16C11/0671 ,  F16C33/103 ,  Y10T403/31 ,  Y10T403/315

Abstract: A process for forming the ball and socket joint with bellows seal (10), a bellows seal (10) and a ball and socket joint with bellows seal (10) is provided including a ball pivot pin (36, 38) with a connection piece (40). The sealing bellows is provided with an annular engagement surface (16) with a cavity (20). The connection piece with a sealing face is connected to the ball pivot pin. Lubricant (22) is disposed in the cavity prior to assembly of the ball and socket joint. The annular engagement surface (16) is provided in contact with the sealing face upon assembly to cause an amount of lubricant (22) to be squeezed out of the cavity (20).

Abstract translation: 一种用于形成具有波纹管密封件（10），波纹管密封件（10）和具有波纹管密封件（10）的球窝接头的球窝接头的方法，包括具有连接件的球形枢轴销（36,38） （40）。 密封波纹管设置有具有空腔（20）的环形接合表面（16）。 具有密封面的连接件连接到球枢轴销。 润滑剂（22）在组装球窝接头之前设置在空腔中。 环形接合表面（16）在组装时设置成与密封面接触，以使一定量的润滑剂（22）被挤出空腔（20）。

公开(公告)号：US5655346A

公开(公告)日：1997-08-12

申请号：US403681

申请日：1995-03-13

Applicant: Eric Holmes ,  Ian Howe

Inventor： Eric Holmes ,  Ian Howe

IPC: E04D3/366 ,  E04B7/00 ,  E06B3/68 ,  E04B9/00

CPC classification number: E06B3/68

Abstract: A structural mounting system for mounting of structural components includes a base section and a co-operating section each of which in use is secured to a respective structural component and which are assembled together. The base section in cross section includes an undercut and the co-operating section in cross section includes a leg, having a toe projecting laterally to engage the undercut. When the sections are being coupled together the co-operating section is rotated about its longitudinal direction relative to its final position so that lateral movement of the toe to engage beneath the undercut requires the co-operating section to rotate about the longitudinal axis relative to the base section to adopt its final position. Spaced linear restraint points and a rotation restraint point together defining a triangle of points of contact to make the assembly of sections rigid. The sections have co-operating formations which require rotation of the co-operating section relative to the base section in a direction opposite to the direction of rotation to effect engagement of the toe with the undercut during close coupling of the two sections together until the toe reaches the undercut and the co-operating section can rotate to its final position.

Abstract translation: PCT No.PCT / AU94 / 00118 Sec。 371日期1995年3月13日 102（e）1995年3月13日PCT 1994年3月11日PCT公布。 公开号WO94 / 20720 PCT 日期1994年9月15日用于安装结构部件的结构安装系统包括基部和合作部分，每个部分在使用中固定到相应的结构部件并组装在一起。 横截面的基部包括底切，并且横截面的协作部分包括腿部，其具有侧向突出以接合底切的脚趾。 当所述部分被联接在一起时，所述配合部分相对于其最终位置围绕其纵向方向旋转，使得所述脚趾在所述底切下方的横向运动需要所述协作部分相对于所述纵向轴线旋转 基地采取其最终立场。 间隔的线性约束点和旋转约束点一起限定了接触点的三角形，以使部件的组件刚性。 这些部分具有相互作用的构造，其需要在与旋转方向相反的方向上相对于基部旋转的协作部分，以在两个部分紧密耦合之前使脚趾与底切接合，直到脚趾 到达底切，并且合作部分可以旋转到其最终位置。

公开(公告)号：US20110206764A1

公开(公告)日：2011-08-25

申请号：US12741141

申请日：2008-11-05

Applicant: Eric Holmes ,  Michael Hite

Inventor： Eric Holmes ,  Michael Hite

IPC: A61K9/48 ,  A61K31/351 ,  A61K31/19 ,  A61K31/215 ,  A61P31/16

CPC classification number: A61K9/4858 ,  A61K9/0053 ,  A61K9/107 ,  A61K9/4825 ,  A61K31/155 ,  A61K31/196 ,  A61K31/215 ,  A61K31/7012 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18

Abstract: A composition is described having improved oral permeability of polar agents such as neuraminidase inhibitors. The composition includes one or more polar agents and one or more permeability enhancers such that the composition increases the amount of the polar agent capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 Cell membrane in the absence of the permeability enhancer. Oral dosage forms including the composition, and methods of treating or preventing influenza infection are also provided.

Abstract translation: 描述了具有改善的极性剂例如神经氨酸酶抑制剂的口服渗透性的组合物。 该组合物包含一种或多种极性试剂和一种或多种渗透性增强剂，使得组合物相对于能够跨越Caco-2细胞膜的量可以跨Caco-2细胞膜传递至少150％ 在没有渗透性增强剂的情况下，Caco-2细胞膜。 还提供了包括组合物在内的口服剂型，以及治疗或预防流感感染的方法。