公开(公告)号：US20120156243A1

公开(公告)日：2012-06-21

申请号：US12816495

申请日：2010-06-16

Applicant: Charles RICHARDSON ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William T. Tino

Inventor： Charles RICHARDSON ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William T. Tino

IPC: A61K39/125 ,  A61P31/14

CPC classification number: A61K39/12 ,  A61K39/125 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55572 ,  A61K2039/70 ,  C07K16/10 ,  C12N7/00 ,  C12N2770/16023 ,  C12N2770/16034

Abstract: The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

公开(公告)号：US07955603B2

公开(公告)日：2011-06-07

申请号：US12093921

申请日：2007-09-28

Applicant: Charles Richardson ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William T. Tino

Inventor： Charles Richardson ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William T. Tino

IPC: A61K35/00 ,  C12Q1/70

CPC classification number: A61K39/12 ,  A61K39/125 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55572 ,  A61K2039/70 ,  C07K16/10 ,  C12N7/00 ,  C12N2770/16023 ,  C12N2770/16034

Abstract: The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

Abstract translation: 本发明涉及包含诺如病毒抗原和佐剂的抗原性和疫苗组合物，特别是单价VLP和多价VLP的混合物的混合物，以及用于生产单价和多价VLP的方法，VLP包含来自一种或多种VLP的衣壳蛋白 更多的诺如病毒基因组。

公开(公告)号：US06630574B1

公开(公告)日：2003-10-07

申请号：US09614124

申请日：2000-07-11

Applicant: Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

Inventor： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

IPC: A61K3816

CPC classification number: C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

Abstract: Compositions comprising isolated cancer-associated L552S polypeptides are disclosed. Such compositions can comprise, for example, portions of said cancer-associated L552S polypeptides and/or the corresponding polynucleotides encoding such portions. Illustrative uses of the compositions, for example in cancer diagnostic methods, are also provided.

Abstract translation: 公开了包含分离的癌相关L552S多肽的组合物。 这样的组合物可以包括例如所述癌相关L552S多肽的部分和/或编码这些部分的相应多核苷酸。 还提供了组合物的说明性用途，例如癌症诊断方法。

公开(公告)号：US06620922B1

公开(公告)日：2003-09-16

申请号：US09636215

申请日：2000-08-09

Applicant: Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

Inventor： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC: C07H2104

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US5258302A

公开(公告)日：1993-11-02

申请号：US560618

申请日：1990-07-30

Applicant: Thomas S. Vedvick ,  Michael E. Engel ,  Mary S. Urcan ,  Richard G. Buckholz ,  Jennifer A. Kinney

Inventor： Thomas S. Vedvick ,  Michael E. Engel ,  Mary S. Urcan ,  Richard G. Buckholz ,  Jennifer A. Kinney

IPC: A61K38/00 ,  C07K14/395 ,  C07K14/81 ,  C12N15/15 ,  C12N15/81 ,  C07K7/10 ,  C12N1/19 ,  C12P21/02

CPC classification number: C12N15/815 ,  C07K14/395 ,  C07K14/8117 ,  A61K38/00 ,  C07K2319/02

Abstract: Biologically active aprotinin (APR) molecules, naturally occurring, relatively short, single chain polypeptides, are prepared by growing methylotrophic yeast transformants containing in their genome at least one copy of a DNA sequence operably encoding APR, in operational association with a DNA sequence encoding the S. cerevisiae alpha mating factor pre-pro sequence (including a processing sequence selected from lys-arg-(glu-ala).sub.x, wherein x is an integer falling in the range of 0-3), both under the regulation of a promoter region of a gene of a methylotrophic yeast, under conditions allowing expression of said DNA sequences, and secretion of APR molecules into the culture medium.Also disclosed are novel DNA fragments and novel recombinant yeast strains which are useful in the practice of the present invention.

Abstract translation: 生物活性抑肽酶（APR）分子，天然存在的，相对短的单链多肽，是通过生长甲基营养酵母转化体来制备的，所述转基因在其基因组中含有至少一个可操作地编码APR的DNA序列拷贝，与编码 酿酒酵母α交配因子前序序列（包括选自lys-arg-（glu-ala）x的加工序列，其中x是0-3范围内的整数），两者均在启动子 区域的甲基营养酵母的基因，允许所述DNA序列表达的条件和APR分子分泌到培养基中。 还公开了可用于本发明实践的新型DNA片段和新型重组酵母菌株。

公开(公告)号：US10130696B2

公开(公告)日：2018-11-20

申请号：US12678813

申请日：2008-09-18

Applicant: Charles Richardson ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William Tino

Inventor： Charles Richardson ,  Thomas S. Vedvick ,  Thomas R. Foubert ,  William Tino

IPC: A61K39/12 ,  C12N7/00 ,  A61K39/00

Abstract: The present invention relates to vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to methods of conferring protective immunity to Norovirus infections in a human subject.

公开(公告)号：US07989605B2

公开(公告)日：2011-08-02

申请号：US11980320

申请日：2007-10-29

Applicant: Steven G. Reed ,  Yasir A. W. Skeiky ,  Davin C. Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas S. Vedvick ,  Daniel R. Twardzik

Inventor： Steven G. Reed ,  Yasir A. W. Skeiky ,  Davin C. Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas S. Vedvick ,  Daniel R. Twardzik

IPC: C07H21/04 ,  C07H21/02 ,  A61K39/04

CPC classification number: C07K14/35 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.

Abstract translation: 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。

公开(公告)号：US20080219988A1

公开(公告)日：2008-09-11

申请号：US11928383

申请日：2007-10-30

Applicant: Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick

Inventor： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick

IPC: A61K39/395 ,  C07K7/06 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C07K16/00 ,  A61K35/12 ,  A61P35/00 ,  A61K38/16 ,  G01N33/574 ,  C07K14/00 ,  C12N5/00 ,  A61K38/08 ,  A61K31/7052

CPC classification number: C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US20080199405A1

公开(公告)日：2008-08-21

申请号：US11801112

申请日：2007-05-07

Applicant: Steven G. Reed ,  Yasir A.W. Skeiky ,  Davin C. Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas S. Vedvick ,  Daniel R. Twardzik ,  Michael J. Lodes ,  Ronald C. Hendrickson

Inventor： Steven G. Reed ,  Yasir A.W. Skeiky ,  Davin C. Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas S. Vedvick ,  Daniel R. Twardzik ,  Michael J. Lodes ,  Ronald C. Hendrickson

IPC: A61K39/00 ,  A61K31/70 ,  A61K49/00 ,  C07K14/00 ,  C12N1/00 ,  C12N15/00 ,  C12N5/06 ,  C12N15/11 ,  C12N1/20 ,  C12M1/34 ,  A61P43/00 ,  A61K38/00

CPC classification number: C07K14/35 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.

Abstract translation: 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。

公开(公告)号：US20080171690A1

公开(公告)日：2008-07-17

申请号：US11929579

申请日：2007-10-30

Applicant: Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D. Kalos ,  Paul R. Sleath ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

Inventor： Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D. Kalos ,  Paul R. Sleath ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

IPC: A61K38/00 ,  C07K4/00 ,  C07K14/00

CPC classification number: C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/47 ,  C07K16/3023 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57423

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

Abstract translation: 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。