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公开(公告)号:US20140303353A1
公开(公告)日:2014-10-09
申请号:US14342017
申请日:2012-08-31
申请人: Alan Hunter , Xiangyang Wang , Timothy Pabst , Michaela Wendeler , Jihong Wang , Kendall Carey , Robert Strouse , Johnson Varghese
发明人: Alan Hunter , Xiangyang Wang , Timothy Pabst , Michaela Wendeler , Jihong Wang , Kendall Carey , Robert Strouse , Johnson Varghese
IPC分类号: C12N9/74 , C07K14/745
CPC分类号: C12N9/6429 , C07K14/745 , C12N9/647
摘要: The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.
摘要翻译: 本申请涉及用于纯化重组凝血因子蛋白的方法,包括例如凝血酶原(凝血因子)(因子II)。 在实施方案中,所述方法提供显示增加的生物活性和降低凝血酶水平的纯化凝血酶原,从而增加凝血酶原的安全性。 还提供了纯化的重组凝血因子蛋白。
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公开(公告)号:US20180360614A1
公开(公告)日:2018-12-20
申请号:US15937868
申请日:2018-03-28
申请人: Aimin Wu , Xiangyang Wang , Yixing Huang , Wenfei Ni , Yan Lin , Zhongke Lin , Hui Xu
发明人: Aimin Wu , Xiangyang Wang , Yixing Huang , Wenfei Ni , Yan Lin , Zhongke Lin , Hui Xu
摘要: The disclosure claims a lumbar interbody fusion cage for treating lumbar spondylolisthesis via a lateral approach. The lumbar interbody fusion cage comprises a supporting frame body, wherein upper and lower blades are mounted on the upper and lower end surfaces of the supporting frame body, a distracting component for driving the upper and lower blades to axially distract along a lumbar interbody and an orthotopic moving component for driving the upper and lower blades to move along the lumbar interbody back and forth are mounted in the supporting frame body, the upper and lower blades respectively extend to form lateral lobes, fixing holes through which fixing nails penetrate are formed on the lateral lobes, the fixing nail of the upper lateral lobe penetrates backward from bottom to top in a slanting way to give a certain rear thrust to the slipped lumbar vertebrae and help reduction of the lumbar spondylolisthesis, and the fixing nailing of the lower lateral lobe penetrates forward from top to bottom to give a forward thrust to the lumbar vertebrae and help the reduction of the lumbar spondylolisthesis. The lumbar interbody fusion cage can solve both an intervertebral spacing and dislocation arisen from forward and backward lumbar spondylolisthesis, has easy operation and small pain to patients, and is safer and more reliable.
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公开(公告)号:US09598687B2
公开(公告)日:2017-03-21
申请号:US14342017
申请日:2012-08-31
申请人: Alan Hunter , Xiangyang Wang , Timothy Pabst , Michaela Wendeler , Jihong Wang , Kendall Carey , Robert Strouse , Johnson Varghese
发明人: Alan Hunter , Xiangyang Wang , Timothy Pabst , Michaela Wendeler , Jihong Wang , Kendall Carey , Robert Strouse , Johnson Varghese
CPC分类号: C12N9/6429 , C07K14/745 , C12N9/647
摘要: The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.
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