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21 条记录 (耗时 0.025 秒)

    Methods and Compositions For The Diagnosis And Treatment Of Cancer and Autoimmune Disorders
    1.
    发明申请
    Methods and Compositions For The Diagnosis And Treatment Of Cancer and Autoimmune Disorders 审中-公开
    用于诊断和治疗癌症和自身免疫性疾病的方法和组合

    公开(公告)号：US20130310266A1

    公开(公告)日：2013-11-21

    申请号：US13820464

    申请日：2011-09-01

    申请人： Xiaowu Liang ,  Douglas Molina ,  William Morrow

    发明人： Xiaowu Liang ,  Douglas Molina ,  William Morrow

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6854 ,  G01N33/564 ,  G01N33/57415

    摘要： Compositions, devices, and methods are contemplated for predicting a patient's likelihood of having a disease. An antigen composition can have a plurality of autoantibody reactive antigens associated with a carrier, where at least two of the antigens have quantified and known relative autoantibody reactivities with respect to sera of a population affected by a disease. The at least two antigens can also have a known association with a disease parameter. A method can include determining autoantibody reactivity against one or more antigens or their variants in a serum sample obtained from a patient, where the autoantibody reactivity against one or more of the antigens indicates an increased likelihood of the patient having a disease.

    摘要翻译： 预期组合物，装置和方法用于预测患者患有疾病的可能性。 抗原组合物可以具有与载体相关的多种自身抗体反应性抗原，其中至少两种抗原相对于受疾病影响的群体的血清具有量化和已知的相对自身抗体反应性。 至少两种抗原也可以具有与疾病参数的已知关联。 一种方法可以包括在从患者获得的血清样品中测定针对一种或多种抗原或其变体的自身抗体反应性，其中针对一种或多种抗原的自身抗体反应表明具有疾病患者的可能性增加。

    Compositions and methods for administering Borrelia DNA
    10.
    发明授权
    Compositions and methods for administering Borrelia DNA 失效
    组合物和施用Borrelia DNA的方法

    公开(公告)号：US06451769B1

    公开(公告)日：2002-09-17

    申请号：US09173053

    申请日：1998-10-15

    申请人： Robert C. Huebner ,  Jon A. Norman ,  Xiaowu Liang ,  Kristin R. Carner ,  Alan G. Barbour ,  Catherine J. Luke

    发明人： Robert C. Huebner ,  Jon A. Norman ,  Xiaowu Liang ,  Kristin R. Carner ,  Alan G. Barbour ,  Catherine J. Luke

    IPC分类号： A61K3170

    CPC分类号： C07K14/20 ,  A61K39/00 ,  C12N15/85 ,  Y02A50/401 ,  Y10S977/804

    摘要： Disclosed is a vaccine against Lyme Disease or its causative agent Borrelia burgdorferi (sensu stricto or sensu lato) containing a plasmid a DNA encoding a promoter for driving expression in a mammalian cell, DNA encoding a leader peptide for facilitating secretion/release of a prokaryotic protein sequence from a mammalian cell, a DNA encoding Borrelia OspA or OspB, and a DNA encoding a terminator. Disclosed too is an immunogenic composition against Lyme Disease or its causative agent Borrelia burgdorferi (sensu stricto or sensu lato) containing a plasmid comprising a DNA encoding a promoter for driving expression in a mammalian cell, DNA encoding a leader peptide for facilitating secretion/release of a prokaryotic protein sequence from a mammalian cell, a DNA encoding a Borrelia OspC, and a DNA encoding a terminator. And, methods for making and using such vaccines and the immunogenic composition are also disclosed.

    摘要翻译： 公开了一种针对莱姆病的疫苗或其致病剂博氏疏螺旋体（sensu stricto或sensu lato），其含有编码用于在哺乳动物细胞中驱动表达的启动子的DNA质粒，编码促进原核蛋白分泌/释放的前导肽的DNA 来自哺乳动物细胞的序列，编码Borrelia OspA或OspB的DNA，以及编码终止子的DNA。 还公开了针对莱姆病或其致病因子伯氏疏螺旋体（sensu stricto或sensu lato）的免疫原性组合物，其包含质粒，其包含编码用于在哺乳动物细胞中驱动表达的启动子的DNA，编码促进分泌/释放的前导肽的DNA 来自哺乳动物细胞的原核蛋白质序列，编码疏螺旋体OspC的DNA和编码终止子的DNA。 并且还公开了制备和使用这些疫苗的方法和免疫原性组合物。