公开(公告)号：US20140123213A1

公开(公告)日：2014-05-01

申请号：US13952245

申请日：2013-07-26

申请人： Alexandru Z. Vank ,  Xin Shen ,  Matt B. Cobb ,  Brad Robel-Forrest ,  Evan M. Phoenix

发明人： Alexandru Z. Vank ,  Xin Shen ,  Matt B. Cobb ,  Brad Robel-Forrest ,  Evan M. Phoenix

IPC分类号： H04L29/06

CPC分类号： H04L63/205 ,  H04L63/08 ,  H04L63/10 ,  H04L63/162 ,  H04L63/20

摘要： The invention enables a client device that does not support IEEE 802.1X authentication to access at least some resources provided through a switch that supports 802.1X authentication by using dynamic authentication with different protocols. When the client device attempts to join a network, the switch monitors for an 802.1X authentication message from the client device. In one embodiment, if the client fails to send an 802.1X authentication message, respond to an 802.1X request from the switch, or a predefined failure condition is detected the client may be deemed incapable of supporting 802.1X authentication. In one embodiment, the client may be initially placed on a quarantine VLAN after determination that the client fails to perform an 802.1X authentication within a backoff time limit. However, the client may still gain access to resources based on various non-802.1X authentication mechanisms, including name/passwords, digital certificates, or the like.

摘要翻译： 本发明使得不支持IEEE 802.1X认证的客户端设备通过使用不同协议的动态认证来访问通过支持802.1X认证的交换机提供的至少一些资源。 当客户端设备尝试加入网络时，交换机会监控来自客户端设备的802.1X认证消息。 在一个实施例中，如果客户端不能发送802.1X认证消息，则从交换机响应802.1X请求，或者检测到预定义的故障条件，则客户端可能被认为不能支持802.1X认证。 在一个实施例中，客户端可以在确定客户端在退避时间限制内未能执行802.1X认证之前被初始化为隔离VLAN。 然而，客户端仍然可以基于各种非802.1X认证机制（包括名称/密码，数字证书等）获得对资源的访问。

公开(公告)号：US20100333176A1

公开(公告)日：2010-12-30

申请号：US12879319

申请日：2010-09-10

申请人： Alexandru Z. Vank ,  Xin Shen ,  Matt B. Cobb ,  Brad Robel-Forrest ,  Evan M. Webb

发明人： Alexandru Z. Vank ,  Xin Shen ,  Matt B. Cobb ,  Brad Robel-Forrest ,  Evan M. Webb

IPC分类号： G06F21/00 ,  G06F15/16

CPC分类号： H04L63/205 ,  H04L63/08 ,  H04L63/10 ,  H04L63/162 ,  H04L63/20

摘要： The invention enables a client device that does not support IEEE 802.1X authentication to access at least some resources provided through a switch that supports 802.1X authentication by using dynamic authentication with different protocols. When the client device attempts to join a network, the switch monitors for an 802.1X authentication message from the client device. In one embodiment, if the client fails to send an 802.1X authentication message, respond to an 802.1X request from the switch, or a predefined failure condition is detected the client may be deemed incapable of supporting 802.1X authentication. In one embodiment, the client may be initially placed on a quarantine VLAN after determination that the client fails to perform an 802.1X authentication within a backoff time limit. However, the client may still gain access to resources based on various non-802.1X authentication mechanisms, including name/passwords, digital certificates, or the like.

摘要翻译： 本发明使得不支持IEEE 802.1X认证的客户端设备通过使用不同协议的动态认证来访问通过支持802.1X认证的交换机提供的至少一些资源。 当客户端设备尝试加入网络时，交换机会监控来自客户端设备的802.1X认证消息。 在一个实施例中，如果客户端不能发送802.1X认证消息，则从交换机响应802.1X请求，或者检测到预定义的故障条件，则客户端可能被认为不能支持802.1X认证。 在一个实施例中，客户端可以在确定客户端在退避时间限制内未能执行802.1X认证之前被初始化为隔离VLAN。 然而，客户端仍然可以基于各种非802.1X认证机制（包括名称/密码，数字证书等）获得对资源的访问。

公开(公告)号：US20100311991A1

公开(公告)日：2010-12-09

申请号：US12741714

申请日：2009-05-22

申请人： Xin Shen ,  Huaxing Zhan ,  Jidong Yang ,  Xiao He ,  Fuxing Lin ,  Shaohong Wu

发明人： Xin Shen ,  Huaxing Zhan ,  Jidong Yang ,  Xiao He ,  Fuxing Lin ,  Shaohong Wu

IPC分类号： C07D305/14 ,  C07C271/66 ,  C07C269/06

CPC分类号： C07D305/14 ,  C07C269/04 ,  C07C269/06 ,  C07C271/22 ,  Y02P20/55

摘要： The present invention disclosed an process for preparing docetaxel 1, including the following steps: a) hydroxyl acylation reaction of compound 2 and 3 to obtain compound 4; b) deprotection group R1 of the hydroxyl group of compound 4 obtained from step a to prepare compound 5; c) removing one tert-butoxycarbonyl of compound 5 obtained from step b to prepare compound 6; d) removing one acetyl of compound 6 obtained from step c to prepare compound 1; wherein, R1 represents tert-butyl dimethyl silyl, triethylsilyl, ethoxyethyl, tetrahydropyranyl, trichloroethoxycarbonyl or methoxymethyl, Boc is tert-butoxycarbonyl, Ac is acetyl, and Ph is phenyl. The present invention also disclosed intermediates of docetaxel and methods for preparation thereof. In the methods for preparation of the present invention, the protective groups used are easy to be removed, the purification of the intermediates is easy, the cost is lower, the yield and the purity are higher, and the processes can be scaled to commercial implementation.

摘要翻译： 本发明公开了一种制备多西紫杉醇1的方法，包括以下步骤：a）化合物2和3的羟基酰化反应得到化合物4; b）由步骤a获得的化合物4的羟基的脱保护基团R1，以制备化合物5; c）除去由步骤b获得的化合物5的一个叔丁氧基羰基，制备化合物6; d）除去由步骤c获得的化合物6的一个乙酰基，制备化合物1; 其中，R1表示叔丁基二甲基甲硅烷基，三乙基甲硅烷基，乙氧基乙基，四氢吡喃基，三氯乙氧基羰基或甲氧基甲基，Boc是叔丁氧基羰基，Ac是乙酰基，Ph是苯基。 本发明还公开了多西紫杉醇的中间体及其制备方法。 在本发明的制备方法中，所使用的保护基团易于除去，中间体的纯化容易，成本低，产率和纯度高，并且可以将其扩展到商业实施 。

公开(公告)号：US07810138B2

公开(公告)日：2010-10-05

申请号：US11337408

申请日：2006-01-23

申请人： Alexandru Zsolt Vank ,  Xin Shen ,  Matt Brian Cobb ,  Brad Robel-Forrest ,  Evan McClendon Phoenix

发明人： Alexandru Zsolt Vank ,  Xin Shen ,  Matt Brian Cobb ,  Brad Robel-Forrest ,  Evan McClendon Phoenix

IPC分类号： H04L9/00 ,  H04L29/06

CPC分类号： H04L63/205 ,  H04L63/08 ,  H04L63/10 ,  H04L63/162 ,  H04L63/20

摘要： The invention enables a client device that does not support IEEE 802.1X authentication to access at least some resources provided through a switch that supports 802.1X authentication by using dynamic authentication with different protocols. When the client device attempts to join a network, the switch monitors for an 802.1X authentication message from the client device. In one embodiment, if the client fails to send an 802.1X authentication message, respond to an 802.1X request from the switch, or a predefined failure condition is detected the client may be deemed incapable of supporting 802.1X authentication. In one embodiment, the client may be initially placed on a quarantine VLAN after determination that the client fails to perform an 802.1X authentication within a backoff time limit. However, the client may still gain access to resources based on various non-802.1X authentication mechanisms, including name/passwords, digital certificates, or the like.

摘要翻译： 本发明使得不支持IEEE 802.1X认证的客户端设备通过使用不同协议的动态认证来访问通过支持802.1X认证的交换机提供的至少一些资源。 当客户端设备尝试加入网络时，交换机会监控来自客户端设备的802.1X认证消息。 在一个实施例中，如果客户端不能发送802.1X认证消息，则从交换机响应802.1X请求，或者检测到预定义的故障条件，则客户端可能被认为不能支持802.1X认证。 在一个实施例中，客户端可以在确定客户端在退避时间限制内未能执行802.1X认证之前被初始化为隔离VLAN。 然而，客户端仍然可以基于各种非802.1X认证机制（包括名称/密码，数字证书等）获得对资源的访问。

公开(公告)号：USD1043681S1

公开(公告)日：2024-09-24

申请号：US35519490

申请日：2023-12-04

申请人： Hai Lu Zhi Xin (Shen Zhen) Co., Ltd.

设计人： Hongxin Ou

摘要： 1. VR head strap
1.1 : Perspective
1.2 : Perspective
1.3 : Front
1.4 : Back
1.5 : Left
1.6 : Right
1.7 : Top
1.8 : Bottom
1.9 : Enlarged
The parts shown by means of broken lines in the reproductions are not part of the claimed design; FIG. 1.9 is the enlarged view of the portion taken at line 1.9 in FIG. 1.1; the dash dot dash broken lines in the reproductions represent boundaries for the enlarged view and form no part of the claimed design.

公开(公告)号：US08522318B2

公开(公告)日：2013-08-27

申请号：US12879319

申请日：2010-09-10

申请人： Alexandru Z. Vank ,  Xin Shen ,  Matt B. Cobb ,  Brad Robel-Forrest ,  Evan M. Webb

发明人： Alexandru Z. Vank ,  Xin Shen ,  Matt B. Cobb ,  Brad Robel-Forrest ,  Evan M. Webb

IPC分类号： H04L9/06 ,  H04L29/06

CPC分类号： H04L63/205 ,  H04L63/08 ,  H04L63/10 ,  H04L63/162 ,  H04L63/20

摘要： The invention enables a client device that does not support IEEE 802.1X authentication to access at least some resources provided through a switch that supports 802.1X authentication by using dynamic authentication with different protocols. When the client device attempts to join a network, the switch monitors for an 802.1X authentication message from the client device. In one embodiment, if the client fails to send an 802.1X authentication message, respond to an 802.1X request from the switch, or a predefined failure condition is detected the client may be deemed incapable of supporting 802.1X authentication. In one embodiment, the client may be initially placed on a quarantine VLAN after determination that the client fails to perform an 802.1X authentication within a backoff time limit. However, the client may still gain access to resources based on various non-802.1X authentication mechanisms, including name/passwords, digital certificates, or the like.

摘要翻译： 本发明使得不支持IEEE 802.1X认证的客户端设备通过使用不同协议的动态认证来访问通过支持802.1X认证的交换机提供的至少一些资源。 当客户端设备尝试加入网络时，交换机会监控来自客户端设备的802.1X认证消息。 在一个实施例中，如果客户端不能发送802.1X认证消息，则从交换机响应802.1X请求，或者检测到预定义的故障条件，则客户端可能被认为不能支持802.1X认证。 在一个实施例中，客户端可以在确定客户端在退避时间限制内未能执行802.1X认证之前被初始化为隔离VLAN。 然而，客户端仍然可以基于各种非802.1X认证机制（包括名称/密码，数字证书等）获得对资源的访问。

公开(公告)号：US20100177750A1

公开(公告)日：2010-07-15

申请号：US12319904

申请日：2009-01-13

申请人： Steven Essinger ,  Xiaoxun Zhu ,  Michael Schnee ,  JiBin Liu ,  Xin Shen ,  LiangLiang Chen ,  Jun Lu ,  Taylor Smith ,  Mark Schmidt

发明人： Steven Essinger ,  Xiaoxun Zhu ,  Michael Schnee ,  JiBin Liu ,  Xin Shen ,  LiangLiang Chen ,  Jun Lu ,  Taylor Smith ,  Mark Schmidt

IPC分类号： H04W4/00

CPC分类号： H04L67/12 ,  H04L41/12 ,  H04L41/22 ,  H04W84/18 ,  H04W88/16

摘要： A wireless sensor communication network supporting a plurality of electronic-ink display sensor devices adapted for use in environments where a local source of electrical power is not available at the point of sensing/monitoring, and there is a need to display sensed data at the point of sensing/monitoring, and minimize the level of servicing required to maintain the wireless sensors. The wireless sensor communication network includes a network gateway device, one or more wireless network routers, a plurality of wireless electronic-ink display sensor devices, and a network coordinator. Each wireless electronic-ink display sensor device comprises: an addressable electronic-ink based display module providing a display surface on which to display graphics. Each wireless electronic-ink display sensor device also includes a power source module including an electrochemical battery, and also a sensor module for sensing a parameter or condition associated with the ambient environment in which the wireless electronic-ink display sensor device is located, generating environmental data representative of the sensed parameter or condition, from which environmental data packets are generated by an onboard programmed processor. The programmed processor, a RF transceiver and a RF antenna cooperate to transmit environmental data packets over the second communication medium, for reception by a network management computer network, and wherein the programmed processor and the addressable electronic-ink based display module cooperate to display the environmental data on the display surface.

摘要翻译： 一种支持多个电子墨水显示传感器装置的无线传感器通信网络，其适用于在感测/监视点处本地电源不可用的环境中，并且需要在该点处显示感测数据 的感测/监控，并将维护无线传感器所需的维修水平降至最低。 无线传感器通信网络包括网络网关设备，一个或多个无线网络路由器，多个无线电子墨水显示传感器设备和网络协调器。 每个无线电子墨水显示传感器装置包括：可寻址电子墨水显示模块，其提供显示图形的显示表面。 每个无线电子墨水显示传感器装置还包括一个包括电化学电池的电源模块，以及一个传感器模块，用于感测与无线电子墨水显示传感器装置所在的周围环境有关的参数或条件，产生环境 表示感测参数或条件的数据，环境数据分组由机载程序处理器产生。 编程处理器，RF收发器和RF天线协作以在第二通信介质上传送环境数据分组，以供网络管理计算机网络接收，并且其中编程处理器和基于可寻址电子墨水的显示模块协同显示 显示表面的环境数据。

公开(公告)号：USD900055S1

公开(公告)日：2020-10-27

申请号：US29737710

申请日：2020-06-11

申请人： Xin Shen

设计人： Xin Shen

公开(公告)号：USD884666S1

公开(公告)日：2020-05-19

申请号：US29721227

申请日：2020-01-18

申请人： Xin Shen

设计人： Xin Shen

公开(公告)号：US08609842B2

公开(公告)日：2013-12-17

申请号：US12866776

申请日：2010-04-23

申请人： Xin Shen ,  Xiao He ,  Jidong Yang ,  Shaohong Wu ,  Huaxing Zhan

发明人： Xin Shen ,  Xiao He ,  Jidong Yang ,  Shaohong Wu ,  Huaxing Zhan

IPC分类号： C07D401/14

CPC分类号： C07D295/12 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

摘要： In the present invention, a synthesis method of Imatinib is disclosed, which comprises the following steps: the Imatinib, namely 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-[4-(3-pyridinyl)-pyrimidin-2-ylamino]-benzami de shown in formula (III), is formed by reacting 4-methyl-N-3-(4-pyridin-3-yl-pyrimidin-2-yl)-1,3-benzenediamine shown in formula (I) with 4-(4-methyl-piperazin-1-methyl)-benzoic ester shown in formula (II), under the action of a base and in a non-protonic organic solvent, in the above generic chemical structural formula, R represents aliphatic alkyl having 1-10 carbon, phenyl, substituted phenyl, benzyl or substituted benzyl. The present invention provides a new synthesis method of Imatinib, which is formed under mild reaction conditions, and is environmentally friendly with a high-yield.

摘要翻译： 在本发明中，公开了伊马替尼的合成方法，其包括以下步骤：伊马替尼，即4-（4-甲基 - 哌嗪-1-基甲基）-N- [4-甲基-3- [4-（ （4-（3-吡啶-3-基 - 嘧啶-2-基）-1-（3-吡啶基） - 嘧啶-2-基氨基] - 苯甲酰胺 式（I）中所示的3-苯二胺与式（II）所示的4-（4-甲基 - 哌嗪-1-甲基） - 苯甲酸酯在碱和非质子有机溶剂的作用下，在 上述通用的化学结构式，R表示具有1-10个碳的脂族烷基，苯基，取代的苯基，苄基或取代的苄基。 本发明提供了在温和的反应条件下形成的伊马替尼的新的合成方法，并且以高产率是环境友好的。