公开(公告)号：US09695208B2

公开(公告)日：2017-07-04

申请号：US13703007

申请日：2011-04-08

申请人： Xinshan Ye ,  Fan Yang ,  Xiujing Zheng

发明人： Xinshan Ye ,  Fan Yang ,  Xiujing Zheng

IPC分类号： C07H15/10 ,  C07H15/04 ,  C07H13/00 ,  A61K47/48 ,  C07K1/107 ,  C07K2/00 ,  A61K39/00

CPC分类号： C07H13/00 ,  A61K39/0011 ,  A61K47/48092 ,  A61K47/48284 ,  A61K47/549 ,  A61K47/643 ,  A61K2039/585 ,  A61K2039/6081 ,  C07H15/04 ,  C07H15/10 ,  C07K1/1077

摘要： N-acyl modified sialic acid (α-(2→6))-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (α-(2→6))-D-aminopyranose derivatives represented by formula 1 are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines.

公开(公告)号：US20130079291A1

公开(公告)日：2013-03-28

申请号：US13703007

申请日：2011-04-08

申请人： Xinshan Ye ,  Fan Yang ,  Xiujing Zheng

发明人： Xinshan Ye ,  Fan Yang ,  Xiujing Zheng

IPC分类号： C07H13/00 ,  C07K2/00

CPC分类号： C07H13/00 ,  A61K39/0011 ,  A61K47/48092 ,  A61K47/48284 ,  A61K47/549 ,  A61K47/643 ,  A61K2039/585 ,  A61K2039/6081 ,  C07H15/04 ,  C07H15/10 ,  C07K1/1077

摘要： N-acyl modified sialic acid (α-(2→6))-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (α-(2→6))-D-aminopyranose derivatives represented by formula 1 are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines.

摘要翻译： 公开了N-酰基改性唾液酸（α-（2→6））-D-氨基吡喃糖衍生物及其合成方法和用途。 通过使用D-氨基半乳糖（葡萄糖）和唾液酸作为原料合成唾液酸（α-（2→6）） - 由式1表示的D-吡喃葡萄糖衍生物，其与载体蛋白或多肽偶联以获得糖蛋白 ）缀合物。 在所述化合物的结构中乙酰基被衍生酰基取代，因此化合物在抗肿瘤疫苗中表现出良好的活性。