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    NSP molecules
    3.
    发明授权
    NSP molecules 失效
    NSP分子

    公开(公告)号：US06891022B1

    公开(公告)日：2005-05-10

    申请号：US09298404

    申请日：1999-04-23

    申请人： Timothy A. Stewart ,  Yanmei Lu

    发明人： Timothy A. Stewart ,  Yanmei Lu

    IPC分类号： C07K16/30 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00

    CPC分类号： C07K16/30

    摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, antagonists and agonists vectors and host cells expressing, and immunoadhesions and antibodies to PRO201, PRO308 or PRO309 polypeptides. The invention further relates to compositions and method for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based in part on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targents for the diagnosis and/or treatment (including prevention) of certain tumors (e.g., cancer) and may act as predictors of the prognosis of tumor treatment.

    摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（ESTs），寡核苷酸探针，多肽，拮抗剂和激动剂载体以及表达PRO101，PRO308或PRO309多肽的免疫粘附和抗体的宿主细胞。 本发明还涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的组合物和方法。 本发明部分基于在肿瘤细胞基因组中扩增的基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，由扩增的基因编码的蛋白质被认为是用于某些肿瘤（例如癌症）的诊断和/或治疗（包括预防））的有用的调节剂，并且可以作为肿瘤治疗预后的预测因子。

    SH2 domain-containing peptides
    4.
    发明授权
    SH2 domain-containing peptides 失效
    含SH2结构域的肽

    公开(公告)号：US06326482B1

    公开(公告)日：2001-12-04

    申请号：US09367206

    申请日：1999-08-09

    申请人： Timothy A. Stewart ,  Yanmei Lu

    发明人： Timothy A. Stewart ,  Yanmei Lu

    IPC分类号： C12P2106

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/24 ,  C07K2319/02 ,  C12N2799/026

    摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, antagonists and agonists vectors and host cells expressing, and immunoadhesions and antibodies to PRO201, PRO308 or PRO309 polypeptides. The invention further relates to compositions and method for the diagnosis and treatment of neoplasfic cell growth and proliferation in mammals, including humans. The invention is based in part on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain tumors (e.g. cancer) and may act as predictors of the prognosis of tumor treatment.

    摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（ESTs），寡核苷酸探针，多肽，拮抗剂和激动剂载体以及表达PRO101，PRO308或PRO309多肽的免疫粘附和抗体的宿主细胞。 本发明还涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的组合物和方法。 本发明部分基于在肿瘤细胞基因组中扩增的基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，被扩增的基因编码的蛋白质被认为是用于某些肿瘤（例如癌症）的诊断和/或治疗（包括预防））的有用靶标，并且可以作为肿瘤治疗预后的预测因子。