公开(公告)号：US08546348B2

公开(公告)日：2013-10-01

申请号：US12924738

申请日：2010-10-04

Applicant: Li-Yen Mae Huang ,  Yanping Gu

Inventor： Li-Yen Mae Huang ,  Yanping Gu

IPC: A01N43/04 ,  A01N43/42 ,  C12Q1/68 ,  C12N15/00

CPC classification number: A61K31/7088 ,  A01K67/027 ,  A01K2207/05 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K48/005 ,  C07K14/705 ,  C12N2799/025 ,  A61K2300/00

Abstract: Disclosed are methods for treating pain in a subject. The method includes upregulating expression of opioid receptors in the subject's dorsal root ganglion or trigeminal neurons. Also disclosed are methods of treating neuropathic and/or chronic pain in a subject. The method includes upregulating expression of μ-opioid or δ-opioid receptors in the subject's dorsal root ganglion or trigeminal neurons.

Abstract translation: 公开了治疗受试者的疼痛的方法。 该方法包括上调受试者背根神经节或三叉神经元中阿片受体的表达。 还公开了治疗受试者的神经病和/或慢性疼痛的方法。 该方法包括在受试者的背根神经节或三叉神经元中上调mu-阿片样物质或δ-阿片受体的表达。

公开(公告)号：US20110091425A1

公开(公告)日：2011-04-21

申请号：US12924738

申请日：2010-10-04

Applicant: Li-Yen Mae Huang ,  Yanping Gu

Inventor： Li-Yen Mae Huang ,  Yanping Gu

IPC: A61K48/00 ,  A61P29/00

CPC classification number: A61K31/7088 ,  A01K67/027 ,  A01K2207/05 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K48/005 ,  C07K14/705 ,  C12N2799/025 ,  A61K2300/00

Abstract: Disclosed are methods for treating pain in a subject. The method includes upregulating expression of opioid receptors in the subject's dorsal root ganglion or trigeminal neurons. Also disclosed are methods of treating neuropathic and/or chronic pain in a subject. The method includes upregulating expression of μ-opioid or δ-opioid receptors in the subject's dorsal root ganglion or trigeminal neurons.

Abstract translation: 公开了治疗受试者的疼痛的方法。 该方法包括上调受试者背根神经节或三叉神经元中阿片受体的表达。 还公开了治疗受试者的神经病和/或慢性疼痛的方法。 该方法包括上调受试者背根神经节或三叉神经元中μ-阿片样物质或δ-阿片受体的表达。

公开(公告)号：US07807651B1

公开(公告)日：2010-10-05

申请号：US12002307

申请日：2007-12-14

Applicant: Li-Yen Mae Huang ,  Yanping Gu ,  Ya Xu

Inventor： Li-Yen Mae Huang ,  Yanping Gu ,  Ya Xu

IPC: A01N43/04 ,  A01N43/42 ,  C12Q1/68 ,  C12N15/00

CPC classification number: A01K67/0275 ,  A01K2207/05 ,  A01K2207/20 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K48/0075 ,  C07K14/705 ,  C12N2799/025 ,  C12N2799/04 ,  C12N2830/008

Abstract: Disclosed are methods for treating pain in a subject. The method includes upregulating expression of opioid receptors in the subject's dorsal root ganglion neurons. Also disclosed are methods of treating neuropathic and/or chronic pain in a subject. The method includes upregulating expression of μ-opioid receptors in the subject's large dorsal root ganglion neurons.

Abstract translation: 公开了治疗受试者的疼痛的方法。 该方法包括上调受试者背根神经节神经元中阿片受体的表达。 还公开了治疗受试者的神经病和/或慢性疼痛的方法。 该方法包括上调受试者大背根神经节神经元中μ-阿片受体的表达。