公开(公告)号：US07399596B2

公开(公告)日：2008-07-15

申请号：US10573072

申请日：2004-09-24

申请人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

发明人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

IPC分类号： G01N33/53

CPC分类号： C12Q1/533 ,  G01N33/689 ,  G01N2800/368

摘要： Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for evaluating a fetus and placental functions in PIH; and a method for detecting PIH, which comprises measuring the level of human lipocalin-type prostaglandin D synthase (L-PGDS) in a body fluid sample collected from a subject.

摘要翻译： 提供：通过精确检测在PIH发病之前发生的异常（其中这种异常不可能通过各种常规的PIH检测方法检测）而预测妊娠诱发的高血压（PIH）的发作的方法，同时施加较少的 一个主题的负担; 用于评估PIH中胎儿和胎盘功能的方法; 以及检测PIH的方法，其包括测量从受试者收集的体液样品中的人脂笼蛋白型前列腺素D合成酶（L-PGDS）的水平。

公开(公告)号：US20070020609A1

公开(公告)日：2007-01-25

申请号：US10573072

申请日：2004-09-24

申请人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

发明人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

IPC分类号： C12Q1/00

CPC分类号： C12Q1/533 ,  G01N33/689 ,  G01N2800/368

摘要： Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for evaluating a fetus and placental functions in PIH; and a method for detecting PIH, which comprises measuring the level of human lipocalin-type prostaglandin D synthase (L-PGDS) in a body fluid sample collected from a subject.

摘要翻译： 提供：通过精确检测在PIH发病之前发生的异常（其中这种异常不可能通过各种常规的PIH检测方法检测）而预测妊娠诱发的高血压（PIH）的发作的方法，同时施加较少的 一个主题的负担; 用于评估PIH中胎儿和胎盘功能的方法; 以及检测PIH的方法，其包括测量从受试者收集的体液样品中的人脂笼蛋白型前列腺素D合成酶（L-PGDS）的水平。

公开(公告)号：US20080233597A1

公开(公告)日：2008-09-25

申请号：US10573324

申请日：2004-09-24

申请人： Yasuhiko Shiina ,  Hiroshi Oda ,  Kosuke Seiki ,  Toshio Ushiyama ,  Yoshihiro Urade ,  Naomi Eguchi ,  Yutaka Eguchi

发明人： Yasuhiko Shiina ,  Hiroshi Oda ,  Kosuke Seiki ,  Toshio Ushiyama ,  Yoshihiro Urade ,  Naomi Eguchi ,  Yutaka Eguchi

IPC分类号： G01N33/53 ,  G01N33/00 ,  C07K16/18 ,  G01N33/536

CPC分类号： G01N33/573 ,  C07K16/40 ,  G01N33/564 ,  G01N2333/99 ,  G01N2800/102

摘要： A method of readily detecting or differentiating rheumatoid arthritis, which has so far been diagnosed in a comprehensive manner based on various tests and clinical symptoms, and a method of readily and objectively estimating the stage of disease and the degree of dysfunction with regard to rheumatoid arthritis are provided.The detection and differentiation of rheumatoid arthritis are performed by measuring the levels of L-PGDS in a sample such as a body fluid such that the measurement value is used as an index. Further, the stage of disease or the degree of dysfunction of a rheumatoid arthritis patient is determined using the measurement value as an index.

摘要翻译： 一种容易地检测或分化类风湿性关节炎的方法，其迄今为止已经基于各种试验和临床症状以综合方式进行诊断，以及容易且客观地估计疾病阶段和关于类风湿性关节炎的功能障碍程度的方法 被提供。 类风湿性关节炎的检测和分化通过测定体液等样品中的L-PGDS的水平来进行，以使测定值作为指标。 此外，使用测量值作为指标来确定类风湿性关节炎患者的疾病阶段或功能障碍程度。