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公开(公告)号：US07011951B1
公开(公告)日：2006-03-14
申请号：US09958346
申请日：2000-04-07
Applicant: Setsuko Sahara , Yutaka Eguchi , Yoshihide Tsujimoto
Inventor： Setsuko Sahara , Yutaka Eguchi , Yoshihide Tsujimoto
IPC: G01N33/53
CPC classification number: C07K14/4747 , A61K38/00
Abstract: A polypeptide possessing an action of causing chromatin condensation; a sense nucleic acid encoding the polypeptide; an antisense nucleic acid thereof, a probe or primer capable of specifically binding to the nucleic acid; an antibody or a fragment thereof against the polypeptide; an agent for controlling apoptosis, comprising the nucleic acid, the polypeptide, or the antibody or a fragment thereof; a screening method for a substance for controlling chromatin condensation, comprising evaluating an activity of causing chromatin condensation exhibited by the polypeptide; and a substance for controlling chromatin condensation. The present invention is useful for screening a substance controlling apoptosis, its use for controlling apoptosis and its applications to various diseases accompanying apoptosis.
Abstract translation: 具有引起染色质凝集作用的多肽; 编码该多肽的正义核酸; 其反义核酸，能够特异性结合核酸的探针或引物; 针对多肽的抗体或其片段; 包含核酸，多肽或抗体或其片段的用于控制凋亡的试剂; 一种用于控制染色质缩合的物质的筛选方法，包括评估多肽所表现的引起染色质缩合的活性; 和用于控制染色质凝聚的物质。 本发明可用于筛选控制细胞凋亡的物质，其控制细胞凋亡的用途及其与凋亡相关的各种疾病的应用。
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2.发明申请Method for evaluating a substance capable of effecting on endoplasmic reticulum stress-and/or amyloid beta-induced apoptosis 审中-公开用于评估能够影响内质网应激和/或淀粉样蛋白β诱导凋亡的物质的方法公开(公告)号：US20060024699A1
公开(公告)日：2006-02-02
申请号：US11124103
申请日：2005-05-09
Applicant: Junichi Hitomi , Taiichi Katayama , Yutaka Eguchi , Yoshihide Tsujimoto , Masaya Tohyama
Inventor： Junichi Hitomi , Taiichi Katayama , Yutaka Eguchi , Yoshihide Tsujimoto , Masaya Tohyama
IPC: C12Q1/68 , G01N33/574
CPC classification number: G01N33/5041 , G01N2333/96466 , G01N2510/00
Abstract: The present invention relates to a method for evaluating a substance capable of affecting endoplasmic reticulum stress-induced apoptosis and/or amyloid-β-induced apoptosis, a kit for evaluating the substance and a pharmaceutical composition.
Abstract translation: 本发明涉及一种评估能够影响内质网应激诱导的凋亡和/或淀粉样蛋白-β诱导的细胞凋亡的物质的方法，用于评价该物质和药物组合物的试剂盒。
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公开(公告)号：US09587102B2
公开(公告)日：2017-03-07
申请号：US14118577
申请日：2012-05-18
Applicant: Yutaka Eguchi , Minoru Sakata , Hiroaki Furukawa
Inventor： Yutaka Eguchi , Minoru Sakata , Hiroaki Furukawa
IPC: C08L27/18 , H01L31/048 , C08L71/12 , H01L31/049 , B32B27/28 , C08J5/18
CPC classification number: C08L27/18 , B32B27/285 , B32B2307/3065 , B32B2457/10 , C08J5/18 , C08J2371/12 , C08J2427/18 , C08K5/0066 , C08K5/49 , C08L71/12 , H01L31/049 , Y02E10/50
Abstract: An object of the present invention is to provide a flame-retardant resin composition having high flame retardancy, and a flame-retardant resin film having high thickness precision and excellent flame retardancy and a solar battery back sheet. The flame-retardant resin film according to the present invention is a flame-retardant resin film obtained from a resin composition, wherein the resin composition comprises a polyphenylene ether resin (a), a phosphorus flame retardant (b), and a fluorine-containing resin (c); in the resin composition, the content of the component (a) is 75 to 98 parts by mass and the content of the component (b) is 25 to 2 parts by mass, based on 100 parts by mass of the components (a) and (b) in total; the content of a fluorine element in the resin composition is 100 to 1000 mass ppm; and the flame-retardant resin film has a thickness of 20 to 500 μm.
Abstract translation: 本发明的目的是提供一种具有高阻燃性的阻燃性树脂组合物和具有高厚度精度和优异阻燃性的阻燃树脂膜和太阳能电池底片。 根据本发明的阻燃树脂膜是由树脂组合物获得的阻燃性树脂膜，其中树脂组合物包含聚苯醚树脂（a），磷阻燃剂（b）和含氟 树脂（c）; 在树脂组合物中，相对于100质量份的（a）成分和（a）成分，成分（a）的含量为75〜98质量份，成分（b）的含量为25〜2质量份 （b）共计 树脂组合物中的氟元素的含量为100〜1000质量ppm; 阻燃性树脂膜的厚度为20〜500μm。
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公开(公告)号：US08722799B2
公开(公告)日：2014-05-13
申请号：US13133866
申请日：2009-12-04
Applicant: Yutaka Eguchi , Shinichi Shibayama , Yoshifumi Araki
Inventor： Yutaka Eguchi , Shinichi Shibayama , Yoshifumi Araki
CPC classification number: C08L53/025 , C08L23/08 , C08L2205/02 , C08L2207/04 , C08L2312/00 , C08L2666/24 , C08L2666/02 , C08L2666/06
Abstract: There is provided a thermoplastic elastomer composition having excellent flexibility, mechanical properties, scratch resistance, abrasion resistance, and low-temperature characteristics. A crosslinked thermoplastic elastomer composition comprising 5 to 70 parts by mass of (C) a hydrogenated product of a block copolymer having at least one conjugated diene monomer unit block and at least one vinyl aromatic monomer unit block, and 20 to 150 parts by mass of (D) an olefin-based resin, based on 100 parts by mass of the total of (A) an ethylene-α-olefin copolymer comprising an ethylene unit and an α-olefin unit having 3 to 20 carbon atoms, and (B) a copolymer having at least one hydrogenated copolymer block mainly composed of a conjugated diene monomer unit and a vinyl aromatic monomer unit, wherein a mass ratio ((A)/(B)) of the (A) component and the (B) component is from 20/80 to 75/25.
Abstract translation: 提供了具有优异的柔韧性，机械性能，耐刮擦性，耐磨性和低温特性的热塑性弹性体组合物。 一种交联热塑性弹性体组合物，其含有（C）具有至少一个共轭二烯单体单元嵌段和至少一个乙烯基芳香族单体单元嵌段的嵌段共聚物的氢化物，和（C）含有20〜150质量份 （D）烯烃系树脂，以（A）乙烯单元和碳原子数为3〜20的α-烯烃单元的乙烯-α-烯烃共聚物总计为100质量份，（B） 具有至少一个主要由共轭二烯单体单元和乙烯基芳族单体单元组成的氢化共聚物嵌段的共聚物，其中（A）成分和（B）成分的质量比（（A）/（B））为 从20/80到75/25。
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Patent Agency Ranking
公开(公告)号：US20110281994A1
公开(公告)日：2011-11-17
申请号：US13133866
申请日：2009-12-04
Applicant: Yutaka Eguchi , Shinichi Shibayama , Yoshifumi Araki
Inventor： Yutaka Eguchi , Shinichi Shibayama , Yoshifumi Araki
CPC classification number: C08L53/025 , C08L23/08 , C08L2205/02 , C08L2207/04 , C08L2312/00 , C08L2666/24 , C08L2666/02 , C08L2666/06
Abstract: There is provided a thermoplastic elastomer composition having excellent flexibility, mechanical properties, scratch resistance, abrasion resistance, and low-temperature characteristics. A crosslinked thermoplastic elastomer composition comprising 5 to 70 parts by mass of (C) a hydrogenated product of a block copolymer having at least one conjugated diene monomer unit block and at least one vinyl aromatic monomer unit block, and 20 to 150 parts by mass of (D) an olefin-based resin, based on 100 parts by mass of the total of (A) an ethylene-α-olefin copolymer comprising an ethylene unit and an α-olefin unit having 3 to 20 carbon atoms, and (B) a copolymer having at least one hydrogenated copolymer block mainly composed of a conjugated diene monomer unit and a vinyl aromatic monomer unit, wherein a mass ratio ((A)/(B)) of the (A) component and the (B) component is from 20/80 to 75/25.
Abstract translation: 提供了具有优异的柔韧性，机械性能，耐刮擦性，耐磨性和低温特性的热塑性弹性体组合物。 一种交联热塑性弹性体组合物，其含有（C）具有至少一个共轭二烯单体单元嵌段和至少一个乙烯基芳香族单体单元嵌段的嵌段共聚物的氢化物，和（C）含有20〜150质量份 （D）烯烃系树脂，以（A）乙烯单元和碳原子数为3〜20的α-烯烃单元的乙烯-α-烯烃共聚物总计为100质量份，（B） 具有至少一个主要由共轭二烯单体单元和乙烯基芳族单体单元组成的氢化共聚物嵌段的共聚物，其中（A）成分和（B）成分的质量比（（A）/（B））为 从20/80到75/25。
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6.发明申请公开(公告)号：US20130209787A1
公开(公告)日：2013-08-15
申请号：US13702047
申请日：2011-06-09
Applicant: Yutaka Eguchi , Shinichi Shibayama , Yuki Mori , Kaori Komatsu , Hajime Matsuura
Inventor： Yutaka Eguchi , Shinichi Shibayama , Yuki Mori , Kaori Komatsu , Hajime Matsuura
CPC classification number: C08L23/10 , B32B25/08 , B32B27/08 , B32B27/22 , B32B27/28 , B32B27/32 , B60R13/0256 , C08L53/025 , C08L83/04 , Y10T428/249992 , Y10T428/31507 , Y10T428/31663
Abstract: An object of the present invention is to provide a thermoplastic elastomer composition having high molding fluidity, mechanical physical properties, and resistance to wear and providing a good appearance and feeling, and molded products using the same.
Abstract translation: 本发明的目的是提供一种具有高成型流动性，机械物理性能，耐磨性和提供良好外观和感觉的热塑性弹性体组合物，以及使用其的成型制品。
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7.发明申请Method of Detecting or Differentiating Rheumatoid Arthritis and Method of Determining Stage of Disease or Degree of Dysfunction with Regard to Rheumatoid Arthritis 审中-公开检测或分化类风湿关节炎的方法及确定类风湿关节炎疾病或功能障碍程度的方法公开(公告)号：US20080233597A1
公开(公告)日：2008-09-25
申请号：US10573324
申请日：2004-09-24
Applicant: Yasuhiko Shiina , Hiroshi Oda , Kosuke Seiki , Toshio Ushiyama , Yoshihiro Urade , Naomi Eguchi , Yutaka Eguchi
Inventor： Yasuhiko Shiina , Hiroshi Oda , Kosuke Seiki , Toshio Ushiyama , Yoshihiro Urade , Naomi Eguchi , Yutaka Eguchi
IPC: G01N33/53 , G01N33/00 , C07K16/18 , G01N33/536
CPC classification number: G01N33/573 , C07K16/40 , G01N33/564 , G01N2333/99 , G01N2800/102
Abstract: A method of readily detecting or differentiating rheumatoid arthritis, which has so far been diagnosed in a comprehensive manner based on various tests and clinical symptoms, and a method of readily and objectively estimating the stage of disease and the degree of dysfunction with regard to rheumatoid arthritis are provided.The detection and differentiation of rheumatoid arthritis are performed by measuring the levels of L-PGDS in a sample such as a body fluid such that the measurement value is used as an index. Further, the stage of disease or the degree of dysfunction of a rheumatoid arthritis patient is determined using the measurement value as an index.
Abstract translation: 一种容易地检测或分化类风湿性关节炎的方法，其迄今为止已经基于各种试验和临床症状以综合方式进行诊断，以及容易且客观地估计疾病阶段和关于类风湿性关节炎的功能障碍程度的方法 被提供。 类风湿性关节炎的检测和分化通过测定体液等样品中的L-PGDS的水平来进行，以使测定值作为指标。 此外，使用测量值作为指标来确定类风湿性关节炎患者的疾病阶段或功能障碍程度。
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公开(公告)号：US06461827B1
公开(公告)日：2002-10-08
申请号：US09423104
申请日：1999-10-29
Applicant: Hiroshi Oda , Nobuyuki Sato , Masazumi Nishikawa , Kosuke Seiki , Yoshihiro Urade , Yutaka Eguchi , Naomi Eguchi
Inventor： Hiroshi Oda , Nobuyuki Sato , Masazumi Nishikawa , Kosuke Seiki , Yoshihiro Urade , Yutaka Eguchi , Naomi Eguchi
IPC: G01N3353
CPC classification number: G01N33/88 , G01N33/573 , Y10S435/81 , Y10S435/975 , Y10S436/805 , Y10S436/811
Abstract: The present invention provides a method for detecting or predicting ischemic disorders in a subject by using as an indication the concentration of human lipocalin-type prostaglandin D synthase (hPGDS) in body fluid samples from the subject. More specifically, the method comprises comparing the hPGDS concentrations in the body fluid samples from a subject with the reference values established for a normal subject, thereby detecting or predicting the ischemic disorders.
Abstract translation: 本发明提供了通过使用来自受试者的体液样品中的人脂质运载蛋白型前列腺素D合成酶（hPGDS）的浓度的指示来检测或预测受试者的缺血性障碍的方法。 更具体地，该方法包括将来自受试者的体液样品中的hPGDS浓度与为正常受试者建立的参考值进行比较，从而检测或预测缺血性疾病。
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9.发明授权公开(公告)号：US09096748B2
公开(公告)日：2015-08-04
申请号：US13702047
申请日：2011-06-09
Applicant: Yutaka Eguchi , Shinichi Shibayama , Yuki Mori , Kaori Komatsu , Hajime Matsuura
Inventor： Yutaka Eguchi , Shinichi Shibayama , Yuki Mori , Kaori Komatsu , Hajime Matsuura
IPC: C08L23/10 , B32B25/08 , B32B27/08 , B32B27/22 , B32B27/28 , B32B27/32 , C08L53/02 , C08L83/04 , B60R13/02
CPC classification number: C08L23/10 , B32B25/08 , B32B27/08 , B32B27/22 , B32B27/28 , B32B27/32 , B60R13/0256 , C08L53/025 , C08L83/04 , Y10T428/249992 , Y10T428/31507 , Y10T428/31663
Abstract: An object of the present invention is to provide a thermoplastic elastomer composition having high molding fluidity, mechanical physical properties, and resistance to wear and providing a good appearance and feeling, and molded products using the same.
Abstract translation: 本发明的目的是提供一种具有高成型流动性，机械物理性能，耐磨性和提供良好外观和感觉的热塑性弹性体组合物，以及使用其的成型制品。
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