公开(公告)号：US20100280083A1

公开(公告)日：2010-11-04

申请号：US12810275

申请日：2008-12-22

申请人： Takehiro Ishikawa ,  Hitoshi Inoue ,  Satoko Kobayashi ,  Masako Yoshida ,  Hiroaki Shiohara ,  Yasunori Ueno ,  Nobuyuki Tanaka

发明人： Takehiro Ishikawa ,  Hitoshi Inoue ,  Satoko Kobayashi ,  Masako Yoshida ,  Hiroaki Shiohara ,  Yasunori Ueno ,  Nobuyuki Tanaka

IPC分类号： A61K31/4245 ,  C07D271/06 ,  C07D413/04 ,  C07D417/10 ,  A61K31/427 ,  A61P25/16

CPC分类号： C07D271/06 ,  C07D413/04 ,  C07D413/10 ,  C07D417/10

摘要： The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4 is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

摘要翻译： 本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1和R 2各自为氢，低级酰基，低级烷氧基羰基等; 低级酰基，卤代低级烷基羰基，环烷基羰基，任意取代的芳基羰基，低级烷氧基羰基等; R4是表现出强大的COMT抑制活性的低级烷基，卤代低级烷基，环烷基，低级烷氧基 - 低级烷基等。 本发明还提供含有所述化合物的药物组合物及其用途。

公开(公告)号：US07546175B2

公开(公告)日：2009-06-09

申请号：US11819091

申请日：2007-06-25

申请人： Yasunori Ueno ,  Yoshiyuki Sato

发明人： Yasunori Ueno ,  Yoshiyuki Sato

IPC分类号： G06F19/00 ,  G06F7/60

CPC分类号： B29C33/3835 ,  B29D11/00413 ,  B29D11/00538 ,  B29L2011/0016

摘要： A mold with which a molded product in a desired shape with an aspherical curved surface is molded can be designed with high precision by correcting shape deformation of the molded product molded from the mold.A mold 10 in which use surfaces 16 of an upper mold 11 and a lower mold 12 are formed to be design curved surfaces of the optical lens in a spherical shape is prepared. A curved surface shape of the optical lens molded from the mold is measured, a measured value is approximated by an equation (1) which is an equation of an aspherical surface and a curved surface of the molded optical lens is specified as an aspherical surface. Information corresponding to an error between the curved surface of the optical lens specified by the equation of the aspherical surface and the above-described design curved surface is compiled into database for each of characteristics of the optical lens as correction information for molding the optical lens of which curved surface is in the spherical shape. By using the correction information compiled into database, design values of the use surfaces in the upper mold and the lower mold of the mold with which the optical lens of which curved surface in the aspherical shape is molded are corrected to design them. [ Mathematical ⁢ ⁢ expression ⁢ ⁢ 10 ] Z = C ⁢ ⁢ ρ 2 1 + 1 - ( 1 + K ) ⁢ C 2 ⁢ ρ 2 + ∑ i = 2 n ⁢ A 2 ⁢ i ⁢ ρ 2 ⁢ i ( 1 )

公开(公告)号：US20090133993A1

公开(公告)日：2009-05-28

申请号：US12245098

申请日：2008-10-03

申请人： Masayuki ISHIKAWA ,  Yasunori UENO

发明人： Masayuki ISHIKAWA ,  Yasunori UENO

IPC分类号： B65G39/16 ,  B65G17/34

CPC分类号： B65G17/065 ,  B65G17/44

摘要： A top plate conveyor device, in which vibrations and noises are reduced, and the structure is simple and the production assembly and handling are easy. Top plates 110 are removably provided on a rubber toothed belt 120 by engagement members 111 provided on the back surfaces of the top plates 110, and engagement members 111 include sandwiching portions 112 which sandwich the toothed belt 120 from both outer sides in the width direction and terminate in pawl portions 113, which snap-connect the top plates to the toothed belt 120.

摘要翻译： 振动和噪音减小的顶板输送装置，结构简单，生产组装和处理容易。 顶板110通过设置在顶板110的后表面上的接合构件111可拆卸地设置在橡胶齿形带120上，并且接合构件111包括从宽度方向的两个外侧夹持齿形带120的夹持部112， 终止于棘爪部分113，卡爪部分113将顶板卡扣到齿形带120上。

公开(公告)号：US07069107B2

公开(公告)日：2006-06-27

申请号：US10902298

申请日：2004-07-30

申请人： Yasunori Ueno

发明人： Yasunori Ueno

IPC分类号： G06F19/00

CPC分类号： G06Q10/04 ,  G02C13/003 ,  G06Q10/087 ,  G06Q30/06

摘要： The difference in optical performance, such as astigmatism, the radius of curvature of a first surface, etc., of left and right lenses is kept at or below a specific level, and the difference in optical performance and the radius of curvature of the first surfaces between new and old lenses when the wearer changes lenses is also kept at or below a specific level, the result being lenses that are more comfortable to wear and are more attractive.

摘要翻译： 左右透镜的光学性能差异，例如散光，第一表面的曲率半径等保持在或低于特定水平，并且光学性能和曲率半径的差异 当佩戴者改变镜片时，新旧镜片之间的表面也保持在或低于特定水平，结果是穿着更舒适并且更具吸引力的镜片。

公开(公告)号：US5892565A

公开(公告)日：1999-04-06

申请号：US954662

申请日：1997-10-20

申请人： Yasunori Ueno ,  Mitsuhiro Yanari ,  Fumio Takahashi

发明人： Yasunori Ueno ,  Mitsuhiro Yanari ,  Fumio Takahashi

IPC分类号： G02C7/02 ,  G02C7/06

CPC分类号： G02C7/065 ,  G02C7/061

摘要： A progressive multifocal lens is provided with a near part N, a defined vision part F, and an intermediate part P along the main meridian curve MM'. The near center B of the lens is separated from near eyepoint E by a distance of substantially 2 mm to 8 mm in the lower part along the main meridian curve. The refractive power K.sub.E at the near eyepoint, refractive power K.sub.A at the defined center A, and refractive power K.sub.B at the near center B satisfy the condition:0.6

摘要翻译： 渐进多焦点透镜设置有近部分N，定义的视觉部分F和沿主子午线曲线MM'的中间部分P. 沿着主子午线曲线，透镜的近中心B从近眼点E与下半部分基本上2mm至8mm的距离分开。 在近眼点处的屈光力KE，在定义的中心A处的屈光力KA和近中心B处的屈光力KB满足条件：0.6 <（KE-KA）/（KB-KA）<0.9。

公开(公告)号：US5871455A

公开(公告)日：1999-02-16

申请号：US838998

申请日：1997-04-23

申请人： Yasunori Ueno

发明人： Yasunori Ueno

IPC分类号： A61B3/10 ,  A61B3/103 ,  A61B3/107 ,  A61B5/103

CPC分类号： A61B3/107 ,  A61B3/103

摘要： An ophthalmic apparatus having a smaller size while guaranteeing a required optical performance from each optical system component is provided. The ophthalmic apparatus includes a fogging optical system for removing an accommodation power of an eye being examined so that the eye is properly relaxed. A detecting optical system is used for detecting information relating to the eye being examined. The fogging optical system and the detecting optical system share a common lens group containing at least one cemented lens. Positive and negative lenses are included in the cemented lens. The common lens group, as a whole, has a positive refractive power.

摘要翻译： 提供具有较小尺寸同时保证来自每个光学系统部件所需的光学性能的眼科装置。 眼科装置包括雾化光学系统，用于去除正在检查的眼睛的调节力，使得眼睛适当地松弛。 检测光学系统用于检测与被检眼有关的信息。 雾化光学系统和检测光学系统共享包含至少一个胶合透镜的公共透镜组。 正透镜和负透镜包括在胶合透镜中。 共同的透镜组作为一个整体具有正的屈光力。

公开(公告)号：US5752266A

公开(公告)日：1998-05-12

申请号：US571493

申请日：1995-12-13

申请人： Katsuki Miyawaki ,  Yukio Otobe ,  Kimihiko Kazui ,  Hideki Miyasaka ,  Yasunori Ueno ,  Kouji Maruyama

发明人： Katsuki Miyawaki ,  Yukio Otobe ,  Kimihiko Kazui ,  Hideki Miyasaka ,  Yasunori Ueno ,  Kouji Maruyama

IPC分类号： G06F13/18 ,  G06F7/00

CPC分类号： G06F13/18

摘要： Control operations to access a memory changes respective priorities of the operations depending on the situation of the memory, and the operations are arbitrated and scheduled according to the respective, changed priorities, in order to avoid concentration on or rejection of a specific memory access operations and to eliminate an ineffective period. This realizes an efficient memory system without increasing the capacity of a buffer memory, the width of a memory bus, or an operating frequency.

摘要翻译： 访问存储器的控制操作根据存储器的情况改变操作的各个优先级，并且根据各自的改变的优先级对操作进行仲裁和调度，以避免集中或拒绝特定存储器存取操作， 消除无效期。 这实现了高效的存储器系统，而不增加缓冲存储器的容量，存储器总线的宽度或工作频率。

公开(公告)号：US5638213A

公开(公告)日：1997-06-10

申请号：US459315

申请日：1995-06-02

申请人： Yasunori Ueno

发明人： Yasunori Ueno

IPC分类号： G02B25/00

CPC分类号： G02B25/001

摘要： An eyepiece having an apparent field of view of 40.degree. or greater which is provided, in succession from the eye point side, with a first lens unit G1 having positive refractive power as a whole, and a second lens unit G2 having negative refractive power as a whole and having a cemented negative lens disposed with a virtual image formed by the eyepiece interposed between itself and the first lens unit G1, satisfies the following conditions:1.0

摘要翻译： 具有40度以上视场的目镜，从眼点侧依次设置有具有整体正屈光力的第一透镜单元G1和具有负屈光力的第二透镜单元G2， 整体上具有设置有由目镜夹在其自身与第一透镜单元G1之间的目镜形成的虚像的胶合负透镜，满足以下条件：1.0

公开(公告)号：US5555039A

公开(公告)日：1996-09-10

申请号：US518021

申请日：1995-08-22

申请人： Yoichi Iki ,  Nobuyki Miyake ,  Yasunori Ueno

发明人： Yoichi Iki ,  Nobuyki Miyake ,  Yasunori Ueno

IPC分类号： A61B3/103 ,  A61B3/10 ,  A61B3/00

CPC分类号： A61B3/103

摘要： An eye measuring apparatus includes a refracting power detector for measuring the refracting power of an eye to be examined, a fogging producer for moving the position of a target image in the direction of the optical axis of the eye to be examined, and a feedback controller for receiving an output from the refracting power detector, and moving the position of the target image in a direction, in which accommodation of the eye to be examined is relaxed, in accordance with refracting power information measured in a predetermined meridian direction of the eye to be examined and astigmatic information of the eye to be examined obtained from refracting power values measured in a plurality of meridian directions of the eye to be examined.

摘要翻译： 眼睛测量装置包括：用于测量待检眼睛的折射力的折射力检测器，用于使被检眼的光轴方向移动目标图像的位置的雾化生成器;以及反射控制器 用于接收来自折射功率检测器的输出，并且根据在眼睛的预定子午线方向上测量的折射功率信息，沿着要被检查的眼睛的容纳松弛的方向移动目标图像的位置， 从被检眼的多个子午线方向测定的折射功率值得到待检查的眼睛的像散信息。

公开(公告)号：US5537163A

公开(公告)日：1996-07-16

申请号：US462602

申请日：1995-06-05

申请人： Yasunori Ueno

发明人： Yasunori Ueno

IPC分类号： A61B3/10 ,  A61B3/14 ,  A61B18/20

CPC分类号： A61B3/145 ,  A61B2018/2025

摘要： An ophthalmologic apparatus is provided with an illuminating optical system for illuminating a fundus oculi of an inspected eye with an illuminating light, a photographing and observing optical system for photographing and observing the fundus oculi of the inspected eye illuminated with the illuminating light by the illuminating optical system, a reference mark projecting optical system for projecting a reference mark on the fundus oculi of the inspected eye, an in-focus detecting optical system for detecting an in-focus condition between the photographing and observing optical system and the fundus oculi of the inspected eye by receiving an image of the reference mark projected on the fundus oculi of the inspected eye by the reference mark projecting optical system, and positional adjustment detecting optical system for detecting a positional adjustment between the ophthalmologic apparatus and the inspected eye by receiving a beam of light which is radiated from the reference mark projecting optical system and is reflected by a cornea of the inspected eye. The reference mark projecting optical system has a light source for radiating a beam of infrared light and/or a beam of near infrared light.

摘要翻译： 本发明提供一种眼科装置，其具有用照明光照射被检查眼睛的眼底的照明光学系统，用于拍摄和观察用照明光照射的被检查眼睛的眼底的照相和观察光学系统 系统，用于在受检眼睛的眼底上投射参考标记的参考标记投影光学系统，用于检测拍摄和观察光学系统之间的对焦状态的被检测光学系统和被检查眼底的对焦检测光学系统 通过基准标记投影光学系统接收投影在被检查眼睛的眼底上的参考标记的图像，以及位置调整检测光学系统，用于通过接收眼科装置和被检查眼睛之间的光束来检测眼科装置与被检查眼睛之间的位置调整 从参考标记pro辐射的光 注射光学系统并被被检眼的角膜反射。 参考标记投影光学系统具有用于照射红外光束和/或近红外光束的光源。