公开(公告)号：US20100280083A1

公开(公告)日：2010-11-04

申请号：US12810275

申请日：2008-12-22

申请人： Takehiro Ishikawa ,  Hitoshi Inoue ,  Satoko Kobayashi ,  Masako Yoshida ,  Hiroaki Shiohara ,  Yasunori Ueno ,  Nobuyuki Tanaka

发明人： Takehiro Ishikawa ,  Hitoshi Inoue ,  Satoko Kobayashi ,  Masako Yoshida ,  Hiroaki Shiohara ,  Yasunori Ueno ,  Nobuyuki Tanaka

IPC分类号： A61K31/4245 ,  C07D271/06 ,  C07D413/04 ,  C07D417/10 ,  A61K31/427 ,  A61P25/16

CPC分类号： C07D271/06 ,  C07D413/04 ,  C07D413/10 ,  C07D417/10

摘要： The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4 is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

摘要翻译： 本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1和R 2各自为氢，低级酰基，低级烷氧基羰基等; 低级酰基，卤代低级烷基羰基，环烷基羰基，任意取代的芳基羰基，低级烷氧基羰基等; R4是表现出强大的COMT抑制活性的低级烷基，卤代低级烷基，环烷基，低级烷氧基 - 低级烷基等。 本发明还提供含有所述化合物的药物组合物及其用途。

公开(公告)号：US07923462B2

公开(公告)日：2011-04-12

申请号：US12810275

申请日：2008-12-22

申请人： Takehiro Ishikawa ,  Hitoshi Inoue ,  Satoko Kobayashi ,  Masako Yoshida ,  Hiroaki Shiohara ,  Yasunori Ueno ,  Nobuyuki Tanaka

发明人： Takehiro Ishikawa ,  Hitoshi Inoue ,  Satoko Kobayashi ,  Masako Yoshida ,  Hiroaki Shiohara ,  Yasunori Ueno ,  Nobuyuki Tanaka

IPC分类号： A61K31/4245 ,  A61K31/427 ,  C07D271/06 ,  C07D413/04 ,  C07D417/10 ,  A61P25/16

CPC分类号： C07D271/06 ,  C07D413/04 ,  C07D413/10 ,  C07D417/10

摘要： The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4 is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

摘要翻译： 本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1和R 2各自为氢，低级酰基，低级烷氧基羰基等; 低级酰基，卤代低级烷基羰基，环烷基羰基，任意取代的芳基羰基，低级烷氧基羰基等; R4是表现出强大的COMT抑制活性的低级烷基，卤代低级烷基，环烷基，低级烷氧基 - 低级烷基等。 本发明还提供含有所述化合物的药物组合物及其用途。

公开(公告)号：US20110172208A1

公开(公告)日：2011-07-14

申请号：US13002475

申请日：2009-06-26

申请人： Takehiro Ishikawa ,  Satoko Kobayashi ,  Hitoshi Inoue ,  Yasunori Ueno ,  Masako Yoshida ,  Nobuyuki Tanaka

发明人： Takehiro Ishikawa ,  Satoko Kobayashi ,  Hitoshi Inoue ,  Yasunori Ueno ,  Masako Yoshida ,  Nobuyuki Tanaka

IPC分类号： A61K31/55 ,  C07D211/08 ,  C07C233/00 ,  C07D207/00 ,  C07D265/30 ,  C07D223/04 ,  C07D241/04 ,  A61K31/445 ,  A61K31/165 ,  A61K31/40 ,  A61K31/5375 ,  A61K31/4965 ,  A61K31/195 ,  A61P25/16

CPC分类号： C07C205/61 ,  A61K31/192 ,  A61K31/24 ,  A61K31/277 ,  A61K31/351 ,  A61K31/381 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/55 ,  A61K45/06 ,  C07C255/56 ,  C07C255/57 ,  C07C259/10 ,  C07C2601/14 ,  C07C2601/18 ,  C07D261/08 ,  C07D277/24 ,  C07D295/10 ,  C07D309/06 ,  C07D333/22 ,  A61K2300/00

摘要： The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; R4 is cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

摘要翻译： 本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1和R 2各自为氢，低级酰基，低级烷氧基羰基等; R 3是低级烷基，卤素 - 低级烷基，环烷基，杂环烷基，任选取代的芳基，任选取代的杂芳基等; R4是氰基，低级烷氧基羰基，羧基等，其表现出强烈的COMT抑制活性。 本发明还提供含有所述化合物的药物组合物及其用途。

公开(公告)号：US08258162B2

公开(公告)日：2012-09-04

申请号：US13002475

申请日：2009-06-26

申请人： Takehiro Ishikawa ,  Satoko Kobayashi ,  Hitoshi Inoue ,  Yasunori Ueno ,  Masako Yoshida ,  Nobuyuki Tanaka

发明人： Takehiro Ishikawa ,  Satoko Kobayashi ,  Hitoshi Inoue ,  Yasunori Ueno ,  Masako Yoshida ,  Nobuyuki Tanaka

IPC分类号： A61K31/04 ,  A61K31/426 ,  A61K31/42 ,  A61K31/381 ,  C07C205/06 ,  C07D277/20 ,  C07D261/06 ,  C07D333/02

CPC分类号： C07C205/61 ,  A61K31/192 ,  A61K31/24 ,  A61K31/277 ,  A61K31/351 ,  A61K31/381 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/55 ,  A61K45/06 ,  C07C255/56 ,  C07C255/57 ,  C07C259/10 ,  C07C2601/14 ,  C07C2601/18 ,  C07D261/08 ,  C07D277/24 ,  C07D295/10 ,  C07D309/06 ,  C07D333/22 ,  A61K2300/00

摘要： The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; R4 is cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

摘要翻译： 本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1和R 2各自为氢，低级酰基，低级烷氧基羰基等; R 3是低级烷基，卤素 - 低级烷基，环烷基，杂环烷基，任选取代的芳基，任选取代的杂芳基等; R4是氰基，低级烷氧基羰基，羧基等，其表现出强烈的COMT抑制活性。 本发明还提供含有所述化合物的药物组合物及其用途。

公开(公告)号：US09138434B2

公开(公告)日：2015-09-22

申请号：US14002533

申请日：2012-03-12

申请人： Toshihiro Nishimura ,  Hirotaka Teranishi ,  Masako Yoshida ,  Yasunori Ueno ,  Kiyoshi Kasai

发明人： Toshihiro Nishimura ,  Hirotaka Teranishi ,  Masako Yoshida ,  Yasunori Ueno ,  Kiyoshi Kasai

IPC分类号： A61K31/496 ,  C07D495/04 ,  A61K45/06 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545

CPC分类号： A61K31/496 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545 ,  A61K45/06 ,  C07D495/04 ,  A61K2300/00

摘要： The present invention provides compounds represented by the general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is cyano or the like; R2 and R3 are hydrogen or the like; R4 is C1-6 alkyl or the like; R5 is C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, cycloalkyl-C1-6 alkyl, aralkyl or the like; R6 and R7 are each hydrogen, C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, C1-6 alkoxy-C1-6 alkyl, R12R13N—C1-6 alkyl or the like, which exhibit potent dopamine D2 receptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

摘要翻译： 本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1为氰基等; R2和R3是氢等; R4是C1-6烷基等; R 5是C 1-6烷基，卤代C 1-6烷基，环烷基，环烷基-C 1-6烷基，芳烷基等; R 6和R 7各自为氢，C 1-6烷基，卤代C 1-6烷基，环烷基，C 1-6烷氧基-C 1-6烷基，R 12 R 13 N-C 1-6烷基等，其表现出有效的多巴胺D2受体刺激活性。 本发明还提供含有所述化合物的药物组合物及其用途。

公开(公告)号：US20140243311A1

公开(公告)日：2014-08-28

申请号：US14002533

申请日：2012-03-12

申请人： Toshihiro Nishimura ,  Hirotaka Teranshi ,  Masako Yoshida ,  Yasunori Ueno ,  Kiyoshi Kasai

发明人： Toshihiro Nishimura ,  Hirotaka Teranshi ,  Masako Yoshida ,  Yasunori Ueno ,  Kiyoshi Kasai

IPC分类号： A61K31/496 ,  A61K31/4365 ,  A61K45/06 ,  C07D495/04

CPC分类号： A61K31/496 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545 ,  A61K45/06 ,  C07D495/04 ,  A61K2300/00

摘要： The present invention provides compounds represented by the general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is cyano or the like; R2 and R3 are hydrogen or the like; R4 is C1-6 alkyl or the like; R5 is C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, cycloalkyl-C1-6 alkyl, aralkyl or the like; R6 and R7 are each hydrogen, C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, C1-6 alkoxy-C1-6 alkyl, R12R13N—C1-6 alkyl or the like, which exhibit potent dopamine D2 receptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

摘要翻译： 本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1是氰基等; R2和R3是氢等; R4是C1-6烷基等; R 5是C 1-6烷基，卤代C 1-6烷基，环烷基，环烷基-C 1-6烷基，芳烷基等; R 6和R 7各自为氢，C 1-6烷基，卤代C 1-6烷基，环烷基，C 1-6烷氧基-C 1-6烷基，R 12 R 13 N-C 1-6烷基等，其表现出有效的多巴胺D2受体刺激活性。 本发明还提供含有所述化合物的药物组合物及其用途。

公开(公告)号：US08262225B2

公开(公告)日：2012-09-11

申请号：US13018541

申请日：2011-02-01

申请人： Yasunori Ueno ,  Kenichi Takahashi ,  Norikazu Hamanaka

发明人： Yasunori Ueno ,  Kenichi Takahashi ,  Norikazu Hamanaka

IPC分类号： A61B3/02 ,  A61B3/00

CPC分类号： A61B3/1035 ,  A61B3/103

摘要： An eye examination apparatus includes an accommodation power acquisition unit, a corrected accommodation power calculation unit, a drive unit and an accommodative microfluctuation measurement unit. The accommodation power acquisition unit acquires an accommodation power which is determined from a difference between a near point and a distant point of an examined eye. The corrected accommodation power calculation unit calculates an integrated value of the accommodation power and a correction coefficient. The drive unit drives a vision target in a direction of an optical axis of the examined eye. The accommodative microfluctuation measurement unit controls the drive unit to cause the vision target to be arranged onto a corrected accommodation position corresponding to the integrated value, such that the accommodative microfluctuation measurement unit measures an eye accommodation function based on a frequency of appearance of a high frequency component representative of ciliary body accommodative microfluctuation.

摘要翻译： 眼睛检查装置包括调节电力获取单元，校正调节力计算单元，驱动单元和调节微调测量单元。 调节力获取单元获取由检查眼睛的近点和远点之间的差确定的调节力。 校正调节力计算单元计算调节力和校正系数的积分值。 驱动单元沿被检眼的光轴的方向驱动视觉目标。 调节微量测量单元控制驱动单元以使视觉目标被布置在对应于积分值的校正的调节位置上，使得调节微调测量单元基于高频出现的频率来测量眼睛调节功能 代表睫状体调节性微血管的成分。

公开(公告)号：US20110187996A1

公开(公告)日：2011-08-04

申请号：US13018541

申请日：2011-02-01

申请人： Yasunori Ueno ,  Kenichi Takahashi ,  Norikazu Hamanaka

发明人： Yasunori Ueno ,  Kenichi Takahashi ,  Norikazu Hamanaka

IPC分类号： A61B3/09 ,  G02C7/06

CPC分类号： A61B3/1035 ,  A61B3/103

摘要： An eye examination apparatus includes an accommodation power acquisition unit, a corrected accommodation power calculation unit, a drive unit and an accommodative microfluctuation measurement unit. The accommodation power acquisition unit acquires an accommodation power which is determined from a difference between a near point and a distant point of an examined eye. The corrected accommodation power calculation unit calculates an integrated value of the accommodation power and a correction coefficient. The drive unit drives a vision target in a direction of an optical axis of the examined eye. The accommodative microfluctuation measurement unit controls the drive unit to cause the vision target to be arranged onto a corrected accommodation position corresponding to the integrated value, such that the accommodative microfluctuation measurement unit measures an eye accommodation function based on a frequency of appearance of a high frequency component representative of ciliary body accommodative microfluctuation.

摘要翻译： 眼睛检查装置包括调节电力获取单元，校正调节力计算单元，驱动单元和调节微调测量单元。 调节力获取单元获取由检查眼睛的近点和远点之间的差确定的调节力。 校正调节力计算单元计算调节力和校正系数的积分值。 驱动单元沿被检眼的光轴的方向驱动视觉目标。 调节微量测量单元控制驱动单元以使视觉目标被布置在对应于积分值的校正调节位置上，使得调节微调测量单元基于高频出现的频率来测量眼睛调节功能 代表睫状体调节性微血管的成分。

公开(公告)号：US20100054834A1

公开(公告)日：2010-03-04

申请号：US12547594

申请日：2009-08-26

申请人： Yasunori Ueno

发明人： Yasunori Ueno

IPC分类号： G03G15/00 ,  B65H1/00

CPC分类号： B65H3/48 ,  B65H1/266 ,  B65H2301/5143 ,  B65H2405/115 ,  G03G15/6532 ,  G03G21/206

摘要： A warm air generating apparatus includes: a blowing apparatus for generating an air flow in a predetermined direction; a heating member disposed on a flow path of the air flow for heating air; a temperature detection member that has a heat sensing portion and detects a temperature of the heating member; and a biasing member for applying a biasing force that causes the heat sensing portion to contact a part of the heating member.

摘要翻译： 一种暖风产生装置，包括：吹出装置，用于沿预定方向产生空气流; 设置在用于加热空气的空气流的流动路径上的加热构件; 温度检测部件，其具有热检测部，检测所述加热部件的温度; 以及用于施加使热传感部分接触加热构件的一部分的偏压力的偏置构件。

公开(公告)号：US06371479B1

公开(公告)日：2002-04-16

申请号：US09512225

申请日：2000-02-24

申请人： Toshiyuki Osaka ,  Naoki Motobayashi ,  Hiromichi Oguma ,  Hideaki Kimata ,  Yasunori Ueno ,  Hiroshi Kusumoto

发明人： Toshiyuki Osaka ,  Naoki Motobayashi ,  Hiromichi Oguma ,  Hideaki Kimata ,  Yasunori Ueno ,  Hiroshi Kusumoto

IPC分类号： B65H2900

CPC分类号： G03G15/234 ,  B65H15/00 ,  Y10S271/902

摘要： A switchback device has an inverting tray for temporarily holding a sheet guided inside the switchback device thereon; a guide unit for guiding the sheet in pressing contact with the inverting tray when the sheet exits the switchback device in an exiting direction on the inverting tray, the exiting direction opposite to an entering direction of the sheet on the inverting tray; a guide switching unit for selectively changing the guide unit to a sheet guide allow state to allow the sheet to enter in the entering direction on the inverting tray and a sheet pressing state to make the sheet in pressing contact with the inverting; and a sheet transporting unit for transporting the sheet out of the switchback device in the exiting direction on the inverting tray.

摘要翻译： 翻转装置具有翻转托架，用于暂时保持在其内部引导的折返装置中的片材; 引导单元，用于当纸张在翻转托盘上沿排出方向离开转向装置时引导纸张与翻转托盘按压接触，出口方向与翻转托盘上纸张的进入方向相反; 引导切换单元，用于选择性地将引导单元更改为片材引导件允许状态以允许片材在翻转托盘上的进入方向进入，并且片材按压状态以使片材与翻转接触; 以及纸张传送单元，用于在翻转托盘上将出纸方向的纸张从折返装置输出。