TOXIC DETECTION METHOD
    1.
    发明申请
    TOXIC DETECTION METHOD 有权
    毒性检测方法

    公开(公告)号:US20100092487A1

    公开(公告)日:2010-04-15

    申请号:US12306863

    申请日:2007-07-03

    摘要: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.

    摘要翻译: 根据本发明,对金黄色葡萄球菌中含有的Panton-Valentine白细胞素毒素的抗体,使用抗体检测毒素的方法和试剂盒以及含有针对Panton-Valentine白细胞素毒素的抗体的药物组合物 用于治疗由含有PVL的金黄色葡萄球菌引起的PVL感染。 另外,能够结合Panton-Valentine杀白细胞素蛋白F并且对LukD和/或HlgB没有交叉反应性的抗体以及能够结合Panton-Valentine的杀白细胞素S并且至少具有交叉反应性的抗体 提供了LukE,HlgC和HlgA之一。

    Toxin detection method
    2.
    发明授权
    Toxin detection method 有权
    毒素检测方法

    公开(公告)号:US08217150B2

    公开(公告)日:2012-07-10

    申请号:US13113276

    申请日:2011-05-23

    IPC分类号: C07K16/00

    摘要: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.

    摘要翻译: 根据本发明,对金黄色葡萄球菌中含有的Panton-Valentine白细胞素毒素的抗体,使用抗体检测毒素的方法和试剂盒以及含有针对Panton-Valentine白细胞素毒素的抗体的药物组合物 用于治疗由含有PVL的金黄色葡萄球菌引起的PVL感染。 另外,能够结合Panton-Valentine杀白细胞素蛋白F并且对LukD和/或HlgB没有交叉反应性的抗体以及能够结合Panton-Valentine的杀白细胞素S并且至少具有交叉反应性的抗体 提供了LukE,HlgC和HlgA之一。

    TOXIN DETECTION METHOD
    3.
    发明申请
    TOXIN DETECTION METHOD 有权
    毒素检测方法

    公开(公告)号:US20110223614A1

    公开(公告)日:2011-09-15

    申请号:US13113276

    申请日:2011-05-23

    IPC分类号: G01N33/566 C07K16/12

    摘要: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.

    摘要翻译: 根据本发明,对金黄色葡萄球菌中含有的Panton-Valentine白细胞素毒素的抗体,使用抗体检测毒素的方法和试剂盒以及含有针对Panton-Valentine白细胞素毒素的抗体的药物组合物 用于治疗由含有PVL的金黄色葡萄球菌引起的PVL感染。 另外,能够结合Panton-Valentine杀白细胞素蛋白F并且对LukD和/或HlgB没有交叉反应性的抗体以及能够结合Panton-Valentine的杀白细胞素S并且至少具有交叉反应性的抗体 提供了LukE,HlgC和HlgA之一。

    Toxin detection method
    4.
    发明授权
    Toxin detection method 有权
    毒素检测方法

    公开(公告)号:US07947808B2

    公开(公告)日:2011-05-24

    申请号:US12306863

    申请日:2007-07-03

    IPC分类号: C07K16/00 C12P21/08

    摘要: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.

    摘要翻译: 根据本发明,对金黄色葡萄球菌中含有的Panton-Valentine白细胞素毒素的抗体,使用抗体检测毒素的方法和试剂盒以及含有针对Panton-Valentine白细胞素毒素的抗体的药物组合物 用于治疗由含有PVL的金黄色葡萄球菌引起的PVL感染。 另外,能够结合Panton-Valentine杀白细胞素蛋白F并且对LukD和/或HlgB没有交叉反应性的抗体以及能够结合Panton-Valentine的杀白细胞素S并且至少具有交叉反应性的抗体 提供了LukE,HlgC和HlgA之一。