公开(公告)号：US20020076772A1

公开(公告)日：2002-06-20

申请号：US08680139

申请日：1996-07-15

发明人： MYRIAM ELSEVIERS ,  HARALD W. W. ROPER

IPC分类号： C12P007/18

CPC分类号： C07C29/56 ,  C07B2200/07 ,  C12P7/18 ,  Y10S435/921 ,  Y10S435/93 ,  Y10S435/938 ,  Y10S435/94 ,  Y10S435/944 ,  C07C31/18

摘要： The present invention relates to a process for the production of xylitol. Specifically the process comprises two reaction steps. The first step is the fermentative conversion of a hexose to a pentitol. The second step is the catalytic chemical isomerisation of the pentitol to xylitol. Optionally, the xylitol is separated from the other pentitols.

摘要翻译： 本发明涉及生产木糖醇的方法。 具体地说，该方法包括两个反应步骤。 第一步是将己糖发酵转化为戊糖醇。 第二步是将戊糖醇催化化学异构化成木糖醇。 任选地，将木糖醇与其它戊五醇分离。

公开(公告)号：US20010043925A1

公开(公告)日：2001-11-22

申请号：US09801124

申请日：2001-03-05

发明人： Houn Simon Hsia ,  Ping Yang ,  Michael Arnold

IPC分类号： A61K038/16

CPC分类号： C12R1/85 ,  A23L5/00 ,  A23L31/00 ,  A23L31/10 ,  A23L33/14 ,  A23L33/16 ,  C07G17/00 ,  C12N1/16 ,  C12P3/00 ,  Y10S435/94 ,  Y10S435/942

摘要： The present invention solves the need for non-toxic forms of selenium which is an essential part of the human diet. This invention provides novel dried-yeast products containing selenium as well as a method of producing the dried yeast products. The method uses selenium having high biological activity but low toxicity. The invention also provides nutritional supplements containing the novel selenium containing dried yeast products and methods of administering these products and supplements to improve human health. The invention also provides a practically non-toxic yeast selenium product having increased intracellular selenium concentrations and methods to reduce tumor cell growth by administration of a selenium yeast product in combination with chemotherapeutic agents.

摘要翻译： 本发明解决了对人体饮食不可缺少的硒的无毒形式的需要。 本发明提供含有硒的新型干酵母产品以及干酵母产品的生产方法。 该方法采用生物活性高，毒性低的硒。 本发明还提供含有含有新鲜硒的干酵母产品的营养补充剂以及施用这些产品和补充剂以改善人类健康的方法。 本发明还提供了具有增加的细胞内硒浓度的实际上无毒的酵母硒产物和通过与化学治疗剂组合施用硒酵母产物来减少肿瘤细胞生长的方法。

公开(公告)号：US5858764A

公开(公告)日：1999-01-12

申请号：US641181

申请日：1995-10-04

申请人： Klaas Anne Osinga ,  Robert Franciscus Beudeker ,  Johannes Sertus Van der Plaat ,  Johannes Abraham de Hollander

发明人： Klaas Anne Osinga ,  Robert Franciscus Beudeker ,  Johannes Sertus Van der Plaat ,  Johannes Abraham de Hollander

IPC分类号： A21D8/04 ,  C12N1/18 ,  C12N1/19 ,  C12N9/26 ,  C12N15/52 ,  C12N15/81 ,  C12N15/90 ,  C12P7/06 ,  C12N15/56

CPC分类号： C12N9/2408 ,  A21D8/047 ,  C12N1/18 ,  C12N15/52 ,  C12N15/81 ,  C12N15/90 ,  C12P7/06 ,  Y02E50/17 ,  Y10S435/94 ,  Y10S435/942

摘要： New yeast strains providing for an enhanced rate of the fermentation of sugars, and a process to obtain such yeasts and the use of these yeasts. Yeasts capable of improved fermentation of sugars, a process to obtain these yeasts and the use of these yeasts are provided. The yeasts show higher rates of metabolism resulting in for example higher carbon dioxide and ethanol production in media containing sugars, such as maltose, as main carbon and energy source. The fermentation rate of sugars is improved by the introduction into a yeast of one or more DNA constructs comprising at least one gene encoding a protein promoting the uptake and/or initial metabolic conversion of a transported sugar substrate.

摘要翻译： 提供糖的发酵速率提高的新的酵母菌株，以及获得这些酵母和使用这些酵母的方法。 提供能够改善糖发酵的酵母，获得这些酵母的方法和这些酵母的使用。 酵母显示出更高的代谢速率，导致例如在含有糖的培养基（例如麦芽糖）作为主要碳和能量来源的较高的二氧化碳和乙醇产生。 通过将包含至少一种编码促进转运的糖底物的摄取和/或初始代谢转化的蛋白质的基因的一种或多种DNA构建体引入酵母中来提高糖的发酵速率。

公开(公告)号：US5054651A

公开(公告)日：1991-10-08

申请号：US609367

申请日：1990-11-05

申请人： Bruno Morane

发明人： Bruno Morane

IPC分类号： B05B9/04 ,  B65D83/14 ,  C09K3/30

CPC分类号： B65D83/625 ,  C09K3/30 ,  Y10S435/94

摘要： In a packaging container (1a) provided with a distribution valve (7), a chamber is provided enclosing the starting components of a system (9) for the anaerobic fermentation of sugars using yeasts, which produce the carbon gas forming said propulsive product. The chamber is composed either of a flexible, gas-tight, hermetically closed pocket (8) or of a small rigid reservoir, which is normally closed by a valve calibrated to open only when the pressure which is established in said reservoir exceeds by a given value the pressure reigning in the interior space of the packing container.

公开(公告)号：US4983520A

公开(公告)日：1991-01-08

申请号：US898425

申请日：1986-08-20

申请人： Fujisawa Yukio ,  Itoh Yasuaki ,  Nishimura Osamu ,  Fujii Tomoko

发明人： Fujisawa Yukio ,  Itoh Yasuaki ,  Nishimura Osamu ,  Fujii Tomoko

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/29 ,  C07K1/20 ,  C07K14/00 ,  C07K14/02 ,  C07K14/10 ,  C07K14/18 ,  C07K14/705 ,  C12N1/13 ,  C12N15/81 ,  C12N15/85 ,  C12P21/02 ,  C12R1/125 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/292 ,  C12N15/81 ,  C12N15/85 ,  A61K2039/523 ,  A61K39/00 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2830/00 ,  C12N2830/005 ,  C12N2830/702 ,  Y10S435/94

摘要： A modified protein (i) derived from a hepatitis B virus surface antigen P31 protein and (ii) having hepatitis B virus surface antigen activity and the ability to bind polymerized human serum albumin, wherein the modification comprises rendering at least one trypsin-like protease sensitive site of the hepatitis B virus surface antigen P31 protein insensitive. The modified protein can be used in the production of a vaccine for prevention of hepatitis B virus infections and as an antigen for diagnosis of hepatitis B virus infections.

摘要翻译： 衍生自乙型肝炎病毒表面抗原P31蛋白的修饰蛋白（i）和（ii）具有乙型肝炎病毒表面抗原活性和结合聚合的人血清白蛋白的能力，其中所述修饰包括使至少一种胰蛋白酶样蛋白酶敏感 乙型肝炎病毒表面抗原P31蛋白的位点不敏感。 修饰的蛋白质可用于生产用于预防乙型肝炎病毒感染的疫苗和用于诊断乙型肝炎病毒感染的抗原。

公开(公告)号：US4772556A

公开(公告)日：1988-09-20

申请号：US883421

申请日：1986-07-14

申请人： Graham G. Stewart ,  Ingeborg Russell ,  Chandrakant J. Panchal

发明人： Graham G. Stewart ,  Ingeborg Russell ,  Chandrakant J. Panchal

IPC分类号： C12N1/18 ,  C12N15/04 ,  C12P7/06 ,  C12N15/00 ,  C12R1/85

CPC分类号： C12N15/04 ,  C12N1/18 ,  C12P7/06 ,  Y02E50/17 ,  Y10S435/94

摘要： The present invention relates to a stable, allopolyploid, somatic fusion product useful in the fermentation arts and especially in the production of fuel alcohols. More particularly, the present invention relates to a novel allopolyploid yeast strain, Saccharomyces diastaticus NCYC 1460, which is the product of the spheroplast fusion of:(a) a hybrid, diploid strain of Sacch. diastaticus; and(b) a fusion partner which is a polyploid brewing yeast strain of the species Saccharomyces uvarum (carlsbergensis).The fusion product of the present invention is capable of an enhanced rate of fermentation and a generally higher degree of final attenuation than is typical of either of the fusion partners. Moreover the fusion product also evidences enhanced osmo- and thermo-tolerances and its multiple, non-allelic DEX gene complement renders the organism well suited to the fermentation of substrates containing dextrins and oligosaccharides.

摘要翻译： 本发明涉及一种用于发酵领域，特别是生产燃料醇的稳定的异倍体体细胞融合产物。 更具体地说，本发明涉及一种新型异折麦酵母菌株，Saccharomyces diastaticus NCYC 1460，它是以下成分之一：（a）Sacchus杂交二倍体菌株的原生质体融合物的产物。 ; us 和（b）融合配偶体，其是酿酒酵母（Carlsbergensis）的多倍体酿造酵母菌株。 本发明的融合产物能够比两种融合伴侣的典型特征提高发酵速率和一般较高程度的最终衰减。 此外，融合产物还证明增强的渗透和热耐受性及其多重非等位基因DEX基因补体使得生物体非常适合含有糊精和寡糖的底物的发酵。

公开(公告)号：US4769329A

公开(公告)日：1988-09-06

申请号：US393630

申请日：1982-06-30

申请人： Bryan Cooper ,  Werner Kuesters ,  Christoph Martin ,  Hardo Siegel

发明人： Bryan Cooper ,  Werner Kuesters ,  Christoph Martin ,  Hardo Siegel

IPC分类号： C12N1/38 ,  C12P7/56 ,  C12R1/865 ,  C12P29/00 ,  C12R1/09 ,  C12R1/85

CPC分类号： C12P7/56 ,  C12N1/38 ,  Y10S435/835 ,  Y10S435/853 ,  Y10S435/856 ,  Y10S435/94

摘要： A process for the preparation of optically pure D- or L-lactic acid by fermentation of an aqueous nutrient medium, which contains nitrogen, vitamins, aminoacids, sugars and trace elements, by means of a microorganism, at pH 4-6, wherein the nutrient medium contains brewers' yeast as the source of nitrogen, vitamins, aminoacids and trace elements.

摘要翻译： 一种通过在pH 4-6下通过微生物发酵包含氮，维生素，氨基酸，糖和微量元素的含水营养培养基来制备光学纯的D-或L-乳酸的方法，其中 营养培养基含有酿造酵母作为氮源，维生素，氨基酸和微量元素的来源。

公开(公告)号：US4243750A

公开(公告)日：1981-01-06

申请号：US43193

申请日：1979-05-29

申请人： Werner C. Muller ,  Franklyn D. Miller

发明人： Werner C. Muller ,  Franklyn D. Miller

IPC分类号： C12P7/06 ,  C13K1/06 ,  C12P7/14

CPC分类号： C13K1/06 ,  C12P7/06 ,  Y02E50/17 ,  Y10S435/813 ,  Y10S435/94

摘要： Starch is converted to ethanol by a process in which an aqueous starch slurry is hydrolyzed in sequential liquefication and saccharification steps to provide sterile saccharified starch solution containing from about 60 to about 80 weight percent of fermentable sugar based on the weight of the original starch present and the fermentable sugar is thereafter continuously converted by fermentation to dilute aqueous ethanol ("beer") in a series of agitated fermentation vessels which contain progressively more ethanol and less fermentable sugar employing at least two strains of yeast for the fermentation, one of which provides a high rate of ethanol production in a fermentation medium containing a relatively low concentration of ethanol and a relatively high concentration of fermentable sugar and the other of which provides a high rate of ethanol production in a fermentation medium containing a relatively high concentration of ethanol and a relatively low concentration of fermentable sugar.

摘要翻译： 淀粉通过在连续液化和糖化步骤中水解淀粉浆料的方法转化为乙醇，以提供含有约60至约80重量％可发酵糖的无菌糖化淀粉溶液，其基于原始淀粉的重量和 然后通过发酵将可发酵糖连续转化成稀释在一系列搅拌发酵容器中的含水乙醇（“啤酒”），其包含逐渐多的乙醇和较少可发酵的糖，其中使用至少两种用于发酵的酵母菌株，其中之一提供 在含有相对低浓度的乙醇和较高浓度的可发酵糖的发酵培养基中乙醇生产率高，另一种在含有相对较高浓度的乙醇和相对较高浓度的发酵培养基中提供高速率的乙醇生产 低浓度的可发酵糖。

公开(公告)号：US4211798A

公开(公告)日：1980-07-08

申请号：US854718

申请日：1977-11-25

申请人： Allen W. Cater

发明人： Allen W. Cater

IPC分类号： A23K1/00 ,  C12N1/16 ,  A23J1/18 ,  A23L1/28 ,  C12C11/18

CPC分类号： C12N1/16 ,  A23K10/16 ,  Y10S435/94

摘要： The present invention concerns methods for producing food products consisting of highly nutritional proteins and yeast which are substantially devoid of objectionable carbohydrates. The process pertains to the addition of proteinaceous materials at appropriate stages of a yeast fermentation so as to enable the yeast to utilize the carbohydrate constituents of the protein material while recovering the protein with the yeast cells. These protein enriched yeast products are low in ash content with essentially no residual carbohydrates and are useful for fortifying foods and feeds.

摘要翻译： 本发明涉及用于生产由高营养蛋白质和酵母组成的食物的方法，其基本上不含有令人讨厌的碳水化合物。 该方法涉及在酵母发酵的适当阶段添加蛋白质材料，以使得酵母能够利用蛋白质材料的碳水化合物成分，同时用酵母细胞回收蛋白质。 这些富含蛋白质的酵母产品的灰分含量低，基本上没有残留的碳水化合物，并且可用于强化食物和饲料。

公开(公告)号：US4186252A

公开(公告)日：1980-01-29

申请号：US792704

申请日：1977-05-02

申请人： Ludmila Silhankova

发明人： Ludmila Silhankova

IPC分类号： C12C5/02 ,  C12C12/00 ,  C12P17/16 ,  C12D5/02

CPC分类号： C12C5/023 ,  C12C12/006 ,  C12P17/167 ,  Y10S435/94 ,  Y10S435/942

摘要： A method for preparing vitamin B.sub.1 in a fermentation process involves cultivating mutants of yeast of the genus Saccharomyces Meyen emend Reess that synthesize this vitamin from sugars and inorganic salts and excrete it from living cells into fermentation media.

摘要翻译： 在发酵过程中制备维生素B1的方法包括培育梅毒酵母属酵母的突变体，该酵母从糖和无机盐合成该维生素并将其从活细胞排出到发酵培养基中。