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公开(公告)号：US20080199909A1
公开(公告)日：2008-08-21
申请号：US11874100
申请日：2008-01-31
申请人： Ying BUECHLER , Ricky LIEU , Michael ONG , Stuart BUSSELL , Nick KNUDSEN , Ho Sung CHO
发明人： Ying BUECHLER , Ricky LIEU , Michael ONG , Stuart BUSSELL , Nick KNUDSEN , Ho Sung CHO
IPC分类号： C12P21/00
CPC分类号： C07K14/61
摘要： The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
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2.发明申请公开(公告)号：US20080050777A1
公开(公告)日：2008-02-28
申请号：US11874086
申请日：2007-10-17
申请人： Ying BUECHLER , Ricky LIEU , Michael ONG , Stuart BUSSELL , Nick KNUDSEN , Ho Sung CHO
发明人： Ying BUECHLER , Ricky LIEU , Michael ONG , Stuart BUSSELL , Nick KNUDSEN , Ho Sung CHO
CPC分类号： C07K14/61
摘要： The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
摘要翻译： 本发明一般涉及人生长激素（hGH）的生产，纯化和分离。 更具体地，本发明涉及从重组宿主细胞或包括例如酵母，昆虫，哺乳动物和细菌宿主细胞的培养基中生产，纯化和分离基本纯化的hGH。 本发明的方法还可用于纯化与聚合物或其它分子连接的hGH。
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公开(公告)号：US09488660B2
公开(公告)日：2016-11-08
申请号：US12902010
申请日：2010-10-11
CPC分类号： G01N33/6812
摘要： Disclosed herein are methods of detecting non-natural amino acids and polypeptides that include at least one non-natural amino acid. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, including but not limited to oxime, carbonyl, and/or hydroxylamine groups. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, and methods for detecting such polypeptides.
摘要翻译： 本文公开了检测包括至少一种非天然氨基酸的非天然氨基酸和多肽的方法。 非天然氨基酸本身或作为多肽的一部分可以包括宽范围的官能团，包括但不限于肟，羰基和/或羟胺基团。 本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，以及用于检测这些多肽的方法。
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4.发明授权Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer 有权生产与水溶性聚合物共轭高度非天然编码氨基酸的方法公开(公告)号：US08080391B2
公开(公告)日：2011-12-20
申请号：US11315752
申请日：2005-12-21
申请人： Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Sung Cho
发明人： Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Sung Cho
CPC分类号： C07K14/61
摘要： The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
摘要翻译： 本发明一般涉及人生长激素（hGH）的生产，纯化和分离。 更具体地，本发明涉及从重组宿主细胞或包括例如酵母，昆虫，哺乳动物和细菌宿主细胞的培养基中生产，纯化和分离基本纯化的hGH。 本发明的方法还可用于纯化与聚合物或其它分子连接的hGH。
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5.发明授权Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35 有权在35位包含非天然编码氨基酸的人生长激素的制剂公开(公告)号：US07816320B2
公开(公告)日：2010-10-19
申请号：US11316483
申请日：2005-12-21
CPC分类号： A61K47/183 , A61K9/0019 , A61K9/19 , A61K38/27 , A61K47/02 , A61K47/26 , C07K14/61
摘要： Formulations of modified human growth hormone polypeptides are provided.
摘要翻译： 提供了修饰的人生长激素多肽的制剂。
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6.发明申请Formulations of Human Growth Hormone Comprising a Non-Naturally Encoded Amino Acid 有权包含非天然编码氨基酸的人生长激素的制剂公开(公告)号：US20080113912A1
公开(公告)日：2008-05-15
申请号：US11924154
申请日：2007-10-25
CPC分类号： A61K47/183 , A61K9/0019 , A61K9/19 , A61K38/27 , A61K47/02 , A61K47/26 , C07K14/61
摘要： Formulations of modified human growth hormone polypeptides are provided.
摘要翻译： 提供了修饰的人生长激素多肽的制剂。
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7.发明申请公开(公告)号：US20060183198A1
公开(公告)日：2006-08-17
申请号：US11315752
申请日：2005-12-21
申请人： Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Cho
发明人： Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Cho
CPC分类号： C07K14/61
摘要： The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
摘要翻译： 本发明一般涉及人生长激素（hGH）的生产，纯化和分离。 更具体地，本发明涉及从重组宿主细胞或包括例如酵母，昆虫，哺乳动物和细菌宿主细胞的培养基中生产，纯化和分离基本纯化的hGH。 本发明的方法还可用于纯化与聚合物或其它分子连接的hGH。
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8.发明授权公开(公告)号：US08178494B2
公开(公告)日：2012-05-15
申请号：US11924242
申请日：2007-10-25
CPC分类号： A61K38/27 , A61K9/0019 , A61K9/19 , A61K47/02 , A61K47/183 , A61K47/26 , C07K14/61 , C08G65/33396
摘要： Formulations of modified growth hormone polypeptides are provided, including human growth hormone polypeptides with one or more non-naturally encoded amino acids with an increased half-life.
摘要翻译： 提供了修饰的生长激素多肽的制剂，包括具有增加的半衰期的一种或多种非天然编码氨基酸的人生长激素多肽。
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9.发明授权Formulations of human growth hormone comprising a non-naturally encoded amino acid 有权包含非天然编码氨基酸的人生长激素的制剂公开(公告)号：US08163695B2
公开(公告)日：2012-04-24
申请号：US11924154
申请日：2007-10-25
CPC分类号： A61K47/183 , A61K9/0019 , A61K9/19 , A61K38/27 , A61K47/02 , A61K47/26 , C07K14/61
摘要： Formulations of modified human growth hormone polypeptides are provided.
摘要翻译： 提供了修饰的人生长激素多肽的制剂。
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公开(公告)号：US20080113914A1
公开(公告)日：2008-05-15
申请号：US11924242
申请日：2007-10-25
CPC分类号： A61K38/27 , A61K9/0019 , A61K9/19 , A61K47/02 , A61K47/183 , A61K47/26 , C07K14/61 , C08G65/33396
摘要： Formulations of modified human growth hormone polypeptides are provided.
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