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公开(公告)号：US08093356B2
公开(公告)日：2012-01-10
申请号：US11925337
申请日：2007-10-26
Applicant: Anna-Maria A. Hays , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
Inventor： Anna-Maria A. Hays , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
CPC classification number: C07K14/555 , A61K38/00 , C07K14/56
Abstract: Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids.
Abstract translation: 提供了修饰的人干扰素多肽及其用途，包括具有一个或多个非天然编码氨基酸的聚乙二醇化人干扰素多肽。
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2.发明授权Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer 有权生产与水溶性聚合物共轭高度非天然编码氨基酸的方法公开(公告)号：US08080391B2
公开(公告)日：2011-12-20
申请号：US11315752
申请日：2005-12-21
Applicant: Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Sung Cho
Inventor： Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Sung Cho
CPC classification number: C07K14/61
Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
Abstract translation: 本发明一般涉及人生长激素（hGH）的生产，纯化和分离。 更具体地，本发明涉及从重组宿主细胞或包括例如酵母，昆虫，哺乳动物和细菌宿主细胞的培养基中生产，纯化和分离基本纯化的hGH。 本发明的方法还可用于纯化与聚合物或其它分子连接的hGH。
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公开(公告)号：US20080119640A1
公开(公告)日：2008-05-22
申请号：US11925275
申请日：2007-10-26
Applicant: Anna-Maria A. HAYS , Bruce E. KIMMEL , Ho Sung CHO , Bee-Cheng SIM , David C. LITZINGER , Roberto MARIANI , Vadim KRAYNOV , Nick Knudsen , Thomas O. DANIEL , Alan KODER , Stuart BUSSELL , Junjie LIU , Zhenwei MIAO , Theresa MORROW
Inventor： Anna-Maria A. HAYS , Bruce E. KIMMEL , Ho Sung CHO , Bee-Cheng SIM , David C. LITZINGER , Roberto MARIANI , Vadim KRAYNOV , Nick Knudsen , Thomas O. DANIEL , Alan KODER , Stuart BUSSELL , Junjie LIU , Zhenwei MIAO , Theresa MORROW
IPC: C07K14/555
CPC classification number: C07K14/555 , A61K38/00 , C07K14/56
Abstract: Modified human interferon polypeptides and uses thereof are provided.
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4.发明申请公开(公告)号：US20060183198A1
公开(公告)日：2006-08-17
申请号：US11315752
申请日：2005-12-21
Applicant: Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Cho
Inventor： Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Cho
CPC classification number: C07K14/61
Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
Abstract translation: 本发明一般涉及人生长激素（hGH）的生产，纯化和分离。 更具体地，本发明涉及从重组宿主细胞或包括例如酵母，昆虫，哺乳动物和细菌宿主细胞的培养基中生产，纯化和分离基本纯化的hGH。 本发明的方法还可用于纯化与聚合物或其它分子连接的hGH。
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5.发明授权Methods for expression and purification of recombinant human growth hormone mutants 有权表达和纯化重组人生长激素突变体的方法公开(公告)号：US07959926B2
公开(公告)日：2011-06-14
申请号：US11874068
申请日：2007-10-17
Applicant: Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Sung Cho
Inventor： Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Sung Cho
CPC classification number: C07K14/61
Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
Abstract translation: 本发明一般涉及人生长激素（hGH）的生产，纯化和分离。 更具体地说，本发明涉及从包含例如酵母，昆虫，哺乳动物和细菌宿主细胞的重组宿主细胞或培养基中生产，纯化和分离包含非天然编码氨基酸和hGH的基本上纯化的hGH。 本发明的方法还可用于纯化与聚合物或其它分子连接的hGH。
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Patent Agency Ranking
公开(公告)号：US20100135959A1
公开(公告)日：2010-06-03
申请号：US11916026
申请日：2006-06-02
Applicant: Anna-Maria A. Hays Putnam , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
Inventor： Anna-Maria A. Hays Putnam , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
CPC classification number: C07K14/555 , A61K38/00 , C07K14/56
Abstract: Modified human interferon polypeptides and uses thereof are provided.
Abstract translation: 提供了修饰的人干扰素多肽及其用途。
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公开(公告)号：US20080085538A1
公开(公告)日：2008-04-10
申请号：US11874068
申请日：2007-10-17
Applicant: Ying BUECHLER , Ricky LIEU , Michael ONG , Stuart BUSSELL , Nick KNUDSEN , Ho Sung CHO
Inventor： Ying BUECHLER , Ricky LIEU , Michael ONG , Stuart BUSSELL , Nick KNUDSEN , Ho Sung CHO
CPC classification number: C07K14/61
Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
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公开(公告)号：US20230210071A1
公开(公告)日：2023-07-06
申请号：US18181835
申请日：2023-03-10
Applicant: Stuart Bussell
Inventor： Stuart Bussell
Abstract: Floating ponds for the cultivation of algae are disclosed. The floating ponds consist of a buoyant framework, a liner, a culture, and a mooring system. Submersible floating ponds are disclosed with a buoyant framework built from tubes that may be filled or partially filled with, for example, air, or water, or the surrounding water, or the culture, and thereby the present invention provides a framework in which the buoyancy may be modulated. Use of submerging lines and spools are disclosed to control the orientation and depth of the floating pond during submersion.
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公开(公告)号：US20110178029A1
公开(公告)日：2011-07-21
申请号：US12674855
申请日：2008-09-15
Applicant: Nick Knudsen , Stuart Bussell , Vadim Kraynov
Inventor： Nick Knudsen , Stuart Bussell , Vadim Kraynov
CPC classification number: C07K14/775 , C07K2319/00
Abstract: Modified human apolipoprotein A-I polypeptides and uses thereof are provided.
Abstract translation: 提供了修饰的人载脂蛋白A-1多肽及其用途。
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公开(公告)号：US20080199909A1
公开(公告)日：2008-08-21
申请号：US11874100
申请日：2008-01-31
Applicant: Ying BUECHLER , Ricky LIEU , Michael ONG , Stuart BUSSELL , Nick KNUDSEN , Ho Sung CHO
Inventor： Ying BUECHLER , Ricky LIEU , Michael ONG , Stuart BUSSELL , Nick KNUDSEN , Ho Sung CHO
IPC: C12P21/00
CPC classification number: C07K14/61
Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
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