公开(公告)号：US20100056496A1

公开(公告)日：2010-03-04

申请号：US12439771

申请日：2007-09-04

Applicant: Naresh Kumar ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

Inventor： Naresh Kumar ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Rajkumar Shirumalla

IPC: A61K31/55 ,  C07D223/14 ,  A61P1/00 ,  A61P11/00 ,  A61P3/00

CPC classification number: C07D221/24 ,  C07D209/12 ,  C07D209/14

Abstract: The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The present invention also relates to processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors. Formula (I) or a pharmaceutically accepted salt, pharmaceutically acceptable solvate, enantiomers, diastereomer, polymorph or N-oxide thereof, wherein X is.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备本文所述化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。 式（I）或其药学上可接受的盐，药学上可接受的溶剂合物，对映异构体，非对映体，多晶型物或N-氧化物，其中X为。

公开(公告)号：US20090137623A1

公开(公告)日：2009-05-28

申请号：US12158435

申请日：2007-01-02

Applicant: Naresh Kumar ,  Ian Anthony Cliffe ,  Mohammad Salman ,  Venkata P. Palle ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

Inventor： Naresh Kumar ,  Ian Anthony Cliffe ,  Mohammad Salman ,  Venkata P. Palle ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC: A61K31/439 ,  C07D487/08 ,  A61P1/00 ,  A61P3/10 ,  A61P3/04 ,  A61P11/06

CPC classification number: C07D209/52

Abstract: The present invention relates to muscarinic receptor modulators, specifically, 7-oxo-2-azabicyclo[2.2.1]heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, particularly schizophrenia or schizophreniform conditions, mania, pain, bipolar disorder, depression, sleeping disorders, epilepsy, gastrointestinal motility disorders, urinary incontinence, and cognition enhancement.

Abstract translation: 本发明涉及可用于治疗各种疾病和病症（例如阿尔茨海默病，青光眼，精神病）的式（I）的毒蕈碱受体调节剂，具体地，7-氧代-2-氮杂双环[2.2.1]庚烷 特别是精神分裂症或精神分裂症状，躁狂症，疼痛，双相情感障碍，抑郁症，睡眠障碍，癫痫，胃肠动力障碍，尿失禁和认知增强。