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    PHARMACEUTICAL COMPOSITIONS OF MUSCARINIC RECEPTOR ANTAGONISTS
    3.
    发明申请
    PHARMACEUTICAL COMPOSITIONS OF MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
    药物受体拮抗剂的药物组合物

    公开(公告)号：US20090221664A1

    公开(公告)日：2009-09-03

    申请号：US12090805

    申请日：2006-10-19

    申请人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Shivani Malhotra

    发明人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Shivani Malhotra

    IPC分类号： A61K31/403

    CPC分类号： A61K31/401

    摘要： Provided herein are pharmaceutical compositions comprising one or more muscarinic receptor antagonists (“MRA”), and at least one additional active ingredients selected from one or more β2-agonists, p38 MAP kinase inhibitors, PDE-IV inhibitors, corticosteroids or a mixture thereof and optionally one or more pharmaceutically acceptable carriers, excipients or diluents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.

    摘要翻译： 本文提供包含一种或多种毒蕈碱受体拮抗剂（“MRA”）和至少一种选自一种或多种β-激动剂，p38MAP激酶抑制剂，PDE-IV抑制剂，皮质类固醇或其混合物的另外的活性成分的药物组合物， 任选的一种或多种药学上可接受的载体，赋形剂或稀释剂。 此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

    COMPOSITIONS OF PHOSPHODIESTERASE TYPE IV INHIBITORS
    5.
    发明申请
    COMPOSITIONS OF PHOSPHODIESTERASE TYPE IV INHIBITORS 审中-公开
    磷酸二酯酶IV型抑制剂的组合物

    公开(公告)号：US20090054382A1

    公开(公告)日：2009-02-26

    申请号：US12090798

    申请日：2006-10-19

    申请人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Suman Gupta

    发明人： Abhijit Ray ,  Sunanda G. Dastidar ,  Rajkumar Shirumalla ,  Suman Gupta

    IPC分类号： A61K31/573 ,  A61K31/407 ,  A61K31/424

    CPC分类号： A61K31/41

    摘要： Provided herein are pharmaceutical compositions comprising one or more phosphodiesterase inhibitors of type IV (“PDE-IV”), and at least one other active ingredients selected from muscarinic receptor antagonists (MRA), β2-agonists, p38 MAP Kinase inhibitors, and corticosteroids and optionally one or more pharmaceutically acceptable excipients and/or other therapeutic agents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.

    摘要翻译： 本文提供了包含一种或多种IV型磷酸二酯酶抑制剂（“PDE-IV”）和至少一种选自毒蕈碱受体拮抗剂（MRA），β2-激动剂，p38 MAP激酶抑制剂和皮质类固醇的其它活性成分的药物组合物，以及 任选地一种或多种药学上可接受的赋形剂和/或其它治疗剂。 此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

    MONOSACCHARIDE DERIVATIVES
    7.
    发明申请
    MONOSACCHARIDE DERIVATIVES 失效
    单糖衍生物

    公开(公告)号：US20070287673A1

    公开(公告)日：2007-12-13

    申请号：US11755164

    申请日：2007-05-30

    申请人： Ashwani Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    发明人： Ashwani Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    IPC分类号： A61K31/7008

    CPC分类号： C07H13/12 ,  C07H9/04

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

    MONOSACCHARIDE DERIVATIVES
    8.
    发明申请
    MONOSACCHARIDE DERIVATIVES 审中-公开
    单糖衍生物

    公开(公告)号：US20080300196A1

    公开(公告)日：2008-12-04

    申请号：US11866542

    申请日：2007-10-03

    申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Rajkumar Shirumalla ,  Abhijit Ray

    发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Rajkumar Shirumalla ,  Abhijit Ray

    IPC分类号： A61K31/7052 ,  C07H17/02 ,  A61K31/70 ,  A61P9/00 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00 ,  C07H15/00

    CPC分类号： C07H3/02 ,  C07H9/04 ,  C07H15/00

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory, cancer, cardiovascular and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, cancer, cardiovascular diseases, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症，癌症，心血管和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病， 溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒或过敏性鼻炎。 包含本文公开的化合物的药理学组合物和治疗诸如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化症，癌症，心血管疾病，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒症 或使用该化合物的过敏性鼻炎和其它炎症和/或自身免疫性疾病。

    Monosaccharide derivatives
    9.
    发明授权
    Monosaccharide derivatives 失效
    单糖衍生物

    公开(公告)号：US07790689B2

    公开(公告)日：2010-09-07

    申请号：US11755164

    申请日：2007-05-30

    申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    IPC分类号： A61K31/7008 ,  A61K31/7012 ,  A61K31/34 ,  C07H5/04 ,  C07H5/06 ,  C07D323/02 ,  C07D317/00

    CPC分类号： C07H13/12 ,  C07H9/04

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。