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公开(公告)号:US20130157375A1
公开(公告)日:2013-06-20
申请号:US13643198
申请日:2011-04-27
申请人: Robert Hider , Yongmin Ma , Ulrich Schaible , Maria Podinovskaia
发明人: Robert Hider , Yongmin Ma , Ulrich Schaible , Maria Podinovskaia
IPC分类号: C07D213/68 , C07D405/14 , C07D401/14 , C07D405/12 , C07D401/12
CPC分类号: C07D213/68 , C07B2200/11 , C07D213/69 , C07D309/40 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , G01N33/90
摘要: In one aspect, there is provided a fluorescent iron-binding compound bound to a solid phase. Also provided is a method for detecting non-transferrin bound iron in a sample, comprising contacting the sample with a fluorescent iron-binding compound bound to a solid phase and detecting a fluorescent signal derived from the fluorescent iron-binding compound bound to the solid phase, wherein the fluorescent signal is indicative of non-transferrin bound iron levels in the sample. Further provided is use of a fluorescent iron-binding compound bound to a solid phase to detect non-transferrin bound iron in a sample.
摘要翻译: 在一个方面,提供了结合到固相的荧光铁结合化合物。 还提供了一种用于检测样品中非转铁蛋白结合铁的方法,包括使样品与结合到固相的荧光铁结合化合物接触并检测衍生自与固相结合的荧光铁结合化合物的荧光信号 ,其中荧光信号指示样品中非转铁蛋白结合的铁水平。 进一步提供使用与固相结合的荧光铁结合化合物来检测样品中非转铁蛋白结合铁。
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公开(公告)号:US20080116000A1
公开(公告)日:2008-05-22
申请号:US11589160
申请日:2006-10-30
申请人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
发明人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
IPC分类号: B62D13/00
摘要: A steering system for a machine having at least one steerable traction device is disclosed. The steering system may have a steering actuator operatively connected to the at least one steerable traction device, and a travel speed sensor configured to generate a signal indicative of a travel speed of the machine. The steering mechanism may also have an operator input device having a deadzone. The deadzone may vary in response to the signal. The steering system may also have a controller in communication with the steering actuator, the operator input device, and the travel speed sensor. The controller may be configured to affect operation of the steering actuator in response to operation of the operator input device only when the operation of the operator input device deviates from the deadzone.
摘要翻译: 公开了一种用于具有至少一个可转向牵引装置的机器的转向系统。 转向系统可以具有可操作地连接到所述至少一个可转向牵引装置的转向致动器,以及配置成产生指示机器行进速度的信号的行进速度传感器。 转向机构还可以具有具有死区的操作者输入装置。 死区可能因信号而异。 转向系统还可以具有与转向致动器,操作者输入装置和行进速度传感器通信的控制器。 只有当操作者输入装置的操作偏离死区时,控制器可以被配置为响应于操作者输入装置的操作而影响转向致动器的操作。
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公开(公告)号:US09138495B2
公开(公告)日:2015-09-22
申请号:US13884660
申请日:2011-11-11
申请人: James Russell Ballinger , David Berry , Philip John Blower , Yongmin Ma , Gregory Edgar David Mullen
发明人: James Russell Ballinger , David Berry , Philip John Blower , Yongmin Ma , Gregory Edgar David Mullen
CPC分类号: A61K51/0455 , A61K51/0478 , A61K51/088 , A61K51/1033
摘要: The present invention relates to bifunctional compounds, the bifunctional compounds for use in molecular imaging and therapy, methods of molecular imaging using the bifunctional compounds and kits including the bifunctional compounds for use molecular imaging. The bifunctional compounds have a tripodal hydroxypyridinone chelating portion and may be conjugated to a targeting group so that the compounds target specific cells or tissues in a subject.
摘要翻译: 本发明涉及双官能化合物,用于分子成像和治疗的双功能化合物,使用双功能化合物的分子成像方法和包括用于分子成像的双功能化合物的试剂盒。 双功能化合物具有三碘羟基吡啶酮螯合部分并且可以与靶向基团缀合,使得化合物靶向受试者中的特定细胞或组织。
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公开(公告)号:US20140056810A1
公开(公告)日:2014-02-27
申请号:US13884660
申请日:2011-11-11
申请人: James Russell Ballinger , David Berry , Philip John Blower , Yongmin Ma , Gregory Edgar David Mullen
发明人: James Russell Ballinger , David Berry , Philip John Blower , Yongmin Ma , Gregory Edgar David Mullen
CPC分类号: A61K51/0455 , A61K51/0478 , A61K51/088 , A61K51/1033
摘要: The present invention relates to bifunctional compounds, the bifunctional compounds for use in molecular imaging and therapy, methods of molecular imaging using the bifunctional compounds and kits including the bifunctional compounds for use molecular imaging. The bifunctional compounds have a tripodal hydroxypyridinone chelating portion and may be conjugated to a targeting group so that the compounds target specific cells or tissues in a subject.
摘要翻译: 本发明涉及双官能化合物,用于分子成像和治疗的双功能化合物,使用双功能化合物的分子成像方法和包括用于分子成像的双功能化合物的试剂盒。 双功能化合物具有三碘羟基吡啶酮螯合部分并且可以与靶向基团缀合,使得化合物靶向受试者中的特定细胞或组织。
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公开(公告)号:US08046134B2
公开(公告)日:2011-10-25
申请号:US12908116
申请日:2010-10-20
申请人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
发明人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
IPC分类号: B62D12/00
摘要: A steering system for a machine having at least one steerable traction device is disclosed. The steering system may have a steering actuator operatively connected to the at least one steerable traction device, and a travel speed sensor configured to generate a signal indicative of a travel speed of the machine. The steering mechanism may also have an operator input device having a deadzone. The deadzone may vary in response to the signal. The steering system may also have a controller in communication with the steering actuator, the operator input device, and the travel speed sensor. The controller may be configured to affect operation of the steering actuator in response to operation of the operator input device only when the operation of the operator input device deviates from the deadzone.
摘要翻译: 公开了一种用于具有至少一个可转向牵引装置的机器的转向系统。 转向系统可以具有可操作地连接到所述至少一个可转向牵引装置的转向致动器,以及配置成产生指示机器行进速度的信号的行驶速度传感器。 转向机构还可以具有具有死区的操作者输入装置。 死区可能因信号而异。 转向系统还可以具有与转向致动器,操作者输入装置和行进速度传感器通信的控制器。 只有当操作者输入装置的操作偏离死区时,控制器可以被配置为响应于操作者输入装置的操作而影响转向致动器的操作。
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6.
公开(公告)号:US20110035112A1
公开(公告)日:2011-02-10
申请号:US12908116
申请日:2010-10-20
申请人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
发明人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
IPC分类号: B62D12/00
摘要: A steering system for a machine having at least one steerable traction device is disclosed. The steering system may have a steering actuator operatively connected to the at least one steerable traction device, and a travel speed sensor configured to generate a signal indicative of a travel speed of the machine. The steering mechanism may also have an operator input device having a deadzone. The deadzone may vary in response to the signal. The steering system may also have a controller in communication with the steering actuator, the operator input device, and the travel speed sensor. The controller may be configured to affect operation of the steering actuator in response to operation of the operator input device only when the operation of the operator input device deviates from the deadzone.
摘要翻译: 公开了一种用于具有至少一个可转向牵引装置的机器的转向系统。 转向系统可以具有可操作地连接到所述至少一个可转向牵引装置的转向致动器,以及配置成产生指示机器行进速度的信号的行驶速度传感器。 转向机构还可以具有具有死区的操作者输入装置。 死区可能因信号而异。 转向系统还可以具有与转向致动器,操作者输入装置和行进速度传感器通信的控制器。 只有当操作者输入装置的操作偏离死区时,控制器可以被配置为响应于操作者输入装置的操作而影响转向致动器的操作。
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公开(公告)号:US07853380B2
公开(公告)日:2010-12-14
申请号:US12545939
申请日:2009-08-24
申请人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
发明人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
摘要: A steering system for a machine having at least one steerable traction device is disclosed. The steering system may have a steering actuator operatively connected to the at least one steerable traction device, and a travel speed sensor configured to generate a signal indicative of a travel speed of the machine. The steering mechanism may also have an operator input device having a deadzone. The deadzone may vary in response to the signal. The steering system may also have a controller in communication with the steering actuator, the operator input device, and the travel speed sensor. The controller may be configured to affect operation of the steering actuator in response to operation of the operator input device only when the operation of the operator input device deviates from the deadzone.
摘要翻译: 公开了一种用于具有至少一个可转向牵引装置的机器的转向系统。 转向系统可以具有可操作地连接到所述至少一个可转向牵引装置的转向致动器,以及配置成产生指示机器行进速度的信号的行驶速度传感器。 转向机构还可以具有具有死区的操作者输入装置。 死区可能因信号而异。 转向系统还可以具有与转向致动器,操作者输入装置和行进速度传感器通信的控制器。 只有当操作者输入装置的操作偏离死区时,控制器可以被配置为响应于操作者输入装置的操作而影响转向致动器的操作。
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8.
公开(公告)号:US20090312913A1
公开(公告)日:2009-12-17
申请号:US12545939
申请日:2009-08-24
申请人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
发明人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
摘要: A steering system for a machine having at least one steerable traction device is disclosed. The steering system may have a steering actuator operatively connected to the at least one steerable traction device, and a travel speed sensor configured to generate a signal indicative of a travel speed of the machine. The steering mechanism may also have an operator input device having a deadzone. The deadzone may vary in response to the signal. The steering system may also have a controller in communication with the steering actuator, the operator input device, and the travel speed sensor. The controller may be configured to affect operation of the steering actuator in response to operation of the operator input device only when the operation of the operator input device deviates from the deadzone.
摘要翻译: 公开了一种用于具有至少一个可转向牵引装置的机器的转向系统。 转向系统可以具有可操作地连接到所述至少一个可转向牵引装置的转向致动器,以及配置成产生指示机器行进速度的信号的行进速度传感器。 转向机构还可以具有具有死区的操作者输入装置。 死区可能因信号而异。 转向系统还可以具有与转向致动器,操作者输入装置和行进速度传感器通信的控制器。 只有当操作者输入装置的操作偏离死区时,控制器可以被配置为响应于操作者输入装置的操作而影响转向致动器的操作。
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公开(公告)号:US07624836B2
公开(公告)日:2009-12-01
申请号:US11589160
申请日:2006-10-30
申请人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
发明人: Xiaodong Huang , John J. Krone , Brad A. Edler , Mark L. Westphalen , Yongmin Ma , Brent M. Carr
IPC分类号: B62D5/06
摘要: A steering system for a machine having at least one steerable traction device is disclosed. The steering system may have a steering actuator operatively connected to the at least one steerable traction device, and a travel speed sensor configured to generate a signal indicative of a travel speed of the machine. The steering mechanism may also have an operator input device having a deadzone. The deadzone may vary in response to the signal. The steering system may also have a controller in communication with the steering actuator, the operator input device, and the travel speed sensor. The controller may be configured to affect operation of the steering actuator in response to operation of the operator input device only when the operation of the operator input device deviates from the deadzone.
摘要翻译: 公开了一种用于具有至少一个可转向牵引装置的机器的转向系统。 转向系统可以具有可操作地连接到所述至少一个可转向牵引装置的转向致动器,以及配置成产生指示机器行进速度的信号的行驶速度传感器。 转向机构还可以具有具有死区的操作者输入装置。 死区可能因信号而异。 转向系统还可以具有与转向致动器,操作者输入装置和行进速度传感器通信的控制器。 只有当操作者输入装置的操作偏离死区时,控制器可以被配置为响应于操作者输入装置的操作而影响转向致动器的操作。
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