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    NOVEL COMPOUND, AND METHOD FOR MEASURING IRON CONCENTRATION BY USING NOVEL COMPOUND AS CHELATE COLOR FORMER
    1.
    发明申请
    NOVEL COMPOUND, AND METHOD FOR MEASURING IRON CONCENTRATION BY USING NOVEL COMPOUND AS CHELATE COLOR FORMER 有权
    新型化合物和通过使用新型化合物作为铬酸盐颜料来测量铁浓度的方法

    公开(公告)号：US20150260734A1

    公开(公告)日：2015-09-17

    申请号：US14433311

    申请日：2013-10-15

    Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.

    Inventor： Yoshikazu Fujita ,  Toshinari Ohashi ,  Naoyuki Yamamoto ,  Takashi Takagaki ,  Satoshi Hasaba

    IPC: G01N33/84 ,  G01N31/22 ,  G01N33/20 ,  C09B49/12

    CPC classification number: G01N33/84 ,  C09B11/24 ,  C09B11/28 ,  C09B49/12 ,  G01N31/00 ,  G01N31/22 ,  G01N33/20 ,  G01N33/90

    Abstract: The present invention addresses the problem of providing a chelate color former which can measure the concentration of iron with high sensitivity and with low blank values when measuring the concentration of iron, and an iron concentration measurement method and kit that use this chelate color former. The present invention relates to: a compound represented by following formula [1] or a salt thereof wherein, R1 and R2 each independently represent —SO3H or —CO2H; an iron concentration measurement method in which the compound is used as a chelate color former, the compound is brought into contact with iron in a sample, and the concentration of iron in the sample is measured on the basis of the degree of resulting color development; and a kit to be used therein.

    Abstract translation: 本发明解决了提供一种螯合成色剂的问题，其可以测量铁的浓度时可以高灵敏度和低空白值测量铁的浓度，以及使用该螯合色素的铁浓度测量方法和试剂盒。 本发明涉及：由下式[1]表示的化合物或其盐，其中R 1和R 2各自独立地表示-SO 3 H或-CO 2 H; 使用化合物作为螯合色素的铁浓度测定方法，使化合物与样品中的铁接触，并且根据得到的显色程度测量样品中的铁浓度; 和其中使用的试剂盒。

    Enzyme-linked Immunosorbent Assay (ELISA) for Canine Hepcidin
    2.
    发明申请
    Enzyme-linked Immunosorbent Assay (ELISA) for Canine Hepcidin 审中-公开
    酶联免疫吸附测定法（ELISA）

    公开(公告)号：US20100068737A1

    公开(公告)日：2010-03-18

    申请号：US12560672

    申请日：2009-09-16

    Applicant: Michael M. Fry ,  Stephen A. Kania ,  Seung J. Baek

    Inventor： Michael M. Fry ,  Stephen A. Kania ,  Seung J. Baek

    IPC: G01N33/535

    CPC classification number: G01N33/54306 ,  G01N33/90

    Abstract: The present invention relates to the use of hepcidin-specific antibodies for the detection of hepcidin in biological samples for the diagnosis of diseases and disorders related to iron metabolism. Kits useful in screening various subjects suspected of having diseases or disorders associated with iron metabolism are also provided.

    Abstract translation: 本发明涉及铁调素特异性抗体在生物样品中检测铁调素用于诊断与铁代谢有关的疾病和病症的用途。 还提供了用于筛选怀疑患有与铁代谢相关的疾病或病症的各种受试者的试剂盒。

    Molecules and methods using same for measuring non-transferrin bound iron
    4.
    发明申请
    Molecules and methods using same for measuring non-transferrin bound iron 有权
    分子和方法使用它来测量非转铁蛋白结合铁

    公开(公告)号：US20030104491A1

    公开(公告)日：2003-06-05

    申请号：US10283343

    申请日：2002-10-30

    Inventor： Ioav Zvi Cabantchik ,  William Breuer ,  Breno P. Esposito

    IPC: C12N009/10 ,  C12Q001/48 ,  G01N033/53

    CPC classification number: G01N33/90

    Abstract: A molecule suitable for use as an indicator of free iron levels in a biological sample, the molecule including an iron binding moeity and a signal generating moeity, wherein an intensity of the signal generated by the signal generating moeity is related to an amount of the iron bound by the iron binding moeity.

    Abstract translation: 适合用作生物样品中游离铁含量指示剂的分子，该分子包括铁结合力和信号产生气味，其中由信号产生气味产生的信号的强度与铁的量有关 受铁结合力约束。

    Diagnosis and treatment of disorders of iron metabolism
    5.
    发明申请
    Diagnosis and treatment of disorders of iron metabolism 失效
    铁代谢紊乱的诊断和治疗

    公开(公告)号：US20030073635A1

    公开(公告)日：2003-04-17

    申请号：US10242061

    申请日：2002-09-12

    Inventor： Ralf Roddiger ,  Paul Lehmann ,  Lothar Thomas

    IPC: A61K038/22 ,  G01N033/72 ,  G01N033/543

    CPC classification number: G01N33/80 ,  G01N33/90 ,  G01N2800/52 ,  Y10T436/10

    Abstract: The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The differential diagnosis can be used to classify disorders of iron metabolism and to recommend the required treatment and to monitor the progress and response to treatment

    Abstract translation: 本发明涉及通过三个独立参数检测铁代谢紊乱的方法，特别是铁代谢紊乱的鉴别诊断。 鉴别诊断可用于分类铁代谢紊乱，并推荐所需治疗，并监测治疗进展和反应

    Reagent and method for serum iron assay
    6.
    发明授权
    Reagent and method for serum iron assay 失效
    血清铁测定试剂和方法

    公开(公告)号：US5151370A

    公开(公告)日：1992-09-29

    申请号：US596942

    申请日：1990-10-11

    Applicant: Jerry W. Denney

    Inventor： Jerry W. Denney

    IPC: G01N33/84 ,  G01N33/90

    CPC classification number: G01N33/90 ,  G01N33/84

    Abstract: A method utilizing a novel reagent for the assay (determination)of serum iron.The serum iron assay reagent is a single, stable reagent, which includes the chromogen chromazurol B (CAB), chromazurol S (CAS), or an alkali metal, alkaline earth metal, rubidium or ammonium base addition salt of CAB or CAS, a surfactant that forms a ternary complex with iron and the chromogen, a buffer, and dimethylsulfoxide.

    Abstract translation: 一种利用新型试剂测定血清铁的方法。 血清铁测定试剂是一种稳定的试剂，其包括色原铬色谱柱B（CAB），色谱柱S（CAS）或CAB或CAS的碱金属，碱土金属，铷或铵基加成盐，表面活性剂 它们与铁和色原子形成三元复合物，缓冲剂和二甲基亚砜。

    Method of determining unsaturated iron binding capacity in serum
    7.
    发明授权
    Method of determining unsaturated iron binding capacity in serum 失效
    测定血清中不饱和铁结合能力的方法

    公开(公告)号：US3887332A

    公开(公告)日：1975-06-03

    申请号：US34809773

    申请日：1973-04-05

    Applicant: EIKEN CHEMICAL

    Inventor： TAKASE KAZUEI ,  MORIKAWA JUNJI

    IPC: G01N31/00 ,  G01N33/90 ,  G01N33/16

    CPC classification number: G01N33/90 ,  Y10T436/10 ,  Y10T436/103332 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/109163

    Abstract: Unsaturated iron binding capacity of transferrin, a serum protein, is determined by adding an iron solution containing a known quantity of excess iron to the serum to saturate the iron binding capacity of the serum transferrin, removing the remaining surplus iron with an absorbent and making a colorimetric determination by causing iron to be released from transferrin under an acidic condition. Since the iron solution is unstable in alkaline zone, it is stabilized by forming it into nitrilotriacetic acid iron chelates. The stability of iron chelates of sodium bathophenanthroline sulfonate is greater than that of nitrilotriacetic acid. This fact is utilized, and the surplus quantity of nitrilotriacetic acid chelates remaining after the saturation of the iron binding capacity of tranferrin is measured by using sodium bathphenanthroline sulfonate. The sodium bathophenanthroline sulfonate iron chelates have maximum absorbance at the wavelength of 535 nm, and Beer''s law holds for an iron concentration range up to 600 mg/100 ml.

    Abstract translation: 通过向血清中加入含有已知量的过量铁的铁溶液来确定血清蛋白转运蛋白的不饱和铁结合能力，以使血清转铁蛋白的铁结合能力饱和，用吸收剂除去剩余的剩余铁，并制成 在酸性条件下使铁从转铁蛋白中释放而进行比色测定。 由于铁溶液在碱性区域不稳定，因此通过将其形成次氮基三乙酸铁螯合物来稳定。 萘醌磺酸钠铁螯合物的稳定性大于次氮基三乙酸。 利用这一事实，通过使用磺酰基菲咯啉磺酸钠测定铁氰化铁铁结合能力饱和后剩余的次氮基三乙酸螯合物的剩余量。 溴化菲蓝磺酸钠铁螯合物在535nm波长处具有最大吸光度，并且Beer定律适用于高达600mg / 100ml的铁浓度范围。

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