公开(公告)号：US4788191A

公开(公告)日：1988-11-29

申请号：US832138

申请日：1986-04-23

申请人： Kentaro Hiraga ,  Yoshiaki Saji

发明人： Kentaro Hiraga ,  Yoshiaki Saji

IPC分类号： C07D209/44 ,  C07D209/46 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F9/553 ,  C07F9/572 ,  C07F9/59 ,  A61K31/33 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  C07D413/14 ,  C07D403/14 ,  C07D409/14

CPC分类号： C07D401/04 ,  C07D209/46 ,  C07D401/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F9/5532 ,  C07F9/5721 ,  C07F9/591

摘要： The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH.dbd.CH--CH.dbd.CH--, --S--(CH.sub.2).sub.l --S-- (l is an integer of 1 to 3), --N.dbd.CH--CH.dbd.N-- or --(CH.sub.2).sub.m -- (m is an integer of 3 to 5); ring A may optionally be substituted with halogen, nitro, amino, alkanoylamino, alkoxycarbonyl, carboxyl or carbamoyl; and n is an integer of 1 to 3, and salts thereof. The compounds display a strong antianxiety effect to mammalian animals and are useful for the prevention or treatment of a disease such as psychoromatic disease and anxiety neurosis.

公开(公告)号：US4778801A

公开(公告)日：1988-10-18

申请号：US67218

申请日：1987-06-29

申请人： Giichi Goto ,  Yoshiaki Saji

发明人： Giichi Goto ,  Yoshiaki Saji

IPC分类号： A61K31/4427 ,  A61K31/445 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D209/46 ,  C07D317/00 ,  C07D401/06 ,  C07D471/04 ,  C07D491/10 ,  C07D491/113 ,  C07D519/00 ,  A61K31/40

CPC分类号： C07D401/06 ,  C07D471/04 ,  C07D491/10

摘要： A compound of the formula ##STR1## wherein X is hydrogen, halogen or nitro; Ar is phenyl or naphthyridinyl which may optionally be substituted; and either one of Z.sup.1 and Z.sup.2 is hydrogen and the other is lower alkanoyloxy or hydroxy, each of Z.sup.1 and Z.sup.2 is lower alkoxy, or Z.sup.1 and Z.sup.2 combinedly represent hydroxyimino or oxo; and a salt thereof, act on the central nervous system but are weak in adverse effects such as hypnotic and muscle relaxant effects.

公开(公告)号：US4879293A

公开(公告)日：1989-11-07

申请号：US241851

申请日：1988-09-08

申请人： Kentaro Hiraga ,  Yoshiaki Saji

发明人： Kentaro Hiraga ,  Yoshiaki Saji

IPC分类号： C07D209/44 ,  C07D209/46 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F9/553 ,  C07F9/572 ,  C07F9/59

CPC分类号： C07D401/04 ,  C07D209/46 ,  C07D401/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F9/5532 ,  C07F9/5721 ,  C07F9/591

摘要： The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH.dbd.CH--CH.dbd.CH--, --S--(CH.sub.2).sub.l --S-- is an integer of 1 to 3), --N.dbd.CH--CH.dbd.N-- or --(CH.sub.2).sub.m --(m is an integer of 3 to 5); ring A may optionally be substituted with halogen, nitro, amino, alkanoylamino, alkoxycarbonyl, carboxyl or carbamoyl; and n is an integer of 1 to 3, and salts thereof. The compounds display a strong antianxiety effect to mammalian animals and are useful for the prevention or treatment of a disease such as psychoromatic disease and anxiety neurosis.

公开(公告)号：US4695572A

公开(公告)日：1987-09-22

申请号：US774470

申请日：1985-09-10

申请人： Giichi Goto ,  Yoshiaki Saji

发明人： Giichi Goto ,  Yoshiaki Saji

IPC分类号： A61K31/4427 ,  A61K31/445 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D209/46 ,  C07D317/00 ,  C07D401/06 ,  C07D471/04 ,  C07D491/10 ,  C07D491/113 ,  C07D519/00 ,  A61K31/40

CPC分类号： C07D401/06 ,  C07D471/04 ,  C07D491/10

摘要： A compound of the formula ##STR1## wherein X is hydrogen, halogen or nitro; Ar is phenyl or naphthyridinyl which may optionally be substituted; and either one of Z.sup.1 and Z.sup.2 is hydrogen and the other is lower alkanoyloxy or hydroxy, each of Z.sup.1 and Z.sup.2 is lower alkoxy, or Z.sup.1 and Z.sup.2 combinedly represent hydroxyimino, oxo or a group of the formula: ##STR2## in which Y is oxygen or sulfur and A is a branched or unbranched lower alkylene chain; and a salt thereof, act on the central nervous system but are weak in adverse effects such as hypnotic and muscle relaxant effects.

摘要翻译： 式（Ⅰ）化合物，其中X是氢，卤素或硝基; Ar是任选被取代的苯基或萘啶基; 并且Z 1和Z 2中的任一个是氢，另一个是低级烷酰氧基或羟基，Z 1和Z 2各自是低级烷氧基，或者Z 1和Z 2组合地表示羟基亚氨基，氧代或下式的基团：其中Y是 氧或硫，A是支链或非支链的低级亚烷基链; 及其盐起作用于中枢神经系统，但是具有不利影响，例如催眠和肌肉松弛作用。

公开(公告)号：US4590189A

公开(公告)日：1986-05-20

申请号：US478478

申请日：1983-03-24

申请人： Kentaro Hiraga ,  Yoshiaki Saji

发明人： Kentaro Hiraga ,  Yoshiaki Saji

IPC分类号： C07D209/44 ,  C07D209/46 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F9/553 ,  C07F9/572 ,  C07F9/59 ,  C07D413/02 ,  C07D403/04 ,  C07D401/02 ,  C07D209/02 ,  A61K31/535 ,  A61K31/505 ,  A61K31/495 ,  A61K31/47 ,  A61K31/40

CPC分类号： C07D401/04 ,  C07D209/46 ,  C07D401/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F9/5532 ,  C07F9/5721 ,  C07F9/591

摘要： The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH.dbd.CH--CH.dbd.CH--, --S--(CH.sub.2).sub.l --S--(l is an integer of 1 to 3), --N.dbd.CH--CH.dbd.N-- or --(CH.sub.2).sub.m --(m is an integer of 3 to 5); ring A may optionally be substituted with halogen, nitro, amino, alkanoylamino, alkoxycarbonyl, carboxyl or carbamoyl; and n is an integer of 1 to 3, and salts thereof. The compounds display a strong antianxiety effect to mammalian animals and are useful for the prevention or treatment of a disease such as psychosomatic disease and anxiety neurosis.

摘要翻译： 其中X是可任选被取代的环状基团的式“IMAGE”的化合物; Y是任选被酯化或酰胺化的羧基; Z是-CH = CH-CH = CH-，-S-（CH 2）l S-（I是1至3的整数），-N = CH-CH = N-或 - （CH 2）m - （m是 3〜5的整数）; 环A可以任选被卤素，硝基，氨基，烷酰基氨基，烷氧基羰基，羧基或氨基甲酰基取代; n为1〜3的整数，及其盐。 这些化合物对哺乳动物具有强烈的抗焦虑作用，可用于预防或治疗诸如心身疾病和焦虑性神经症等疾病。